Search results for "EXPANSION"

Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model

2012

SummaryMyotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alternative splicing regulators such as MBNL1. MBNL1 sequestration has been associated with key features of DM1. However, the basis behind a number of molecular and histological alterations in DM1 remain unclear. To help identify new pathogenic components of the disease, we carried out a genetic screen using a Drosophila model of DM1 that expresses 480 interrupted CTG repeats, i(CTG)480, and a collection of…

Modeling of Myotonic Dystrophy Cardiac Phenotypes in

2018

After respiratory distress, cardiac dysfunction is the second most common cause of fatality associated with the myotonic dystrophy (DM) disease. Despite the prevalance of heart failure in DM, physiopathological studies on heart symptoms have been relatively scarce because few murine models faithfully reproduce the cardiac disease. Consequently, only a small number of candidate compounds have been evaluated in this specific phenotype. To help cover this gap Drosophila combines the amenability of its invertebrate genetics with the possibility of quickly acquiring physiological parameters suitable for meaningful comparisons with vertebrate animal models and humans. Here we review available des…

¿Quién está buscando su mejor versión? Coaching y psicología deportiva en el proceso de terapeutización de (y desde) el golf

2020

This article asks about the expansion of psychological, therapeutic and self-enhancement ethos through the networks and devices that configures middle and upper-middle classes, and about the ways in which this process is singled out starting from the encounter between coaching and psychology paradigms with golf fans, in contemporary Argentina. The empirical materials that support the analysis have been ethnographically produced from the interaction with golf players and coaches.

Editorial: From Meristems to Floral Diversity: Developmental Options and Constraints

2021

On the asymptotic behaviour of gaussian spherical integrals

1983

Shape Sensitivity Analysis and Gradient-Based Optimization of Large Structures Using MLFMA

2014

A fast method for computing the action of shape-differentiated electric field integral equation (EFIE) system matrix to a vector is derived exploiting the multilevel fast multipole algorithm (MLFMA). The proposed method is used in conjunction with the adjoint-variable method (AVM) to compute the shape gradient of arbitrary objective functions depending on shape of a metallic scatterer. The method is demonstrated numerically by optimizing the shape of a parabolic reflector illuminated with a half-wave dipole.

User session level diverse reranking of search results

2018

Most Web search diversity approaches can be categorized as Document Level Diversification (DocLD), Topic Level Diversification (TopicLD) or Term Level Diversification (TermLD). DocLD selects the relevant documents with minimal content overlap to each other. It does not take the coverage of query subtopics into account. TopicLD solves this by modeling query subtopics explicitly. However, the automatic mining of query subtopics is difficult. TermLD tries to cover as many query topic terms as possible, which reduces the task of finding a query's subtopics into finding a set of representative topic terms. In this paper, we propose a novel User Session Level Diversification (UserLD) approach bas…

Transformations Accompanying a Shift from Surface to Drip Irrigation in the Cànyoles Watershed, Valencia, Spain

2017

Drip irrigation is widely promoted in Spain to increase agricultural production and to save water. In the Cànyoles watershed, Valencia, we analysed the consequences of change from surface irrigation to drip irrigation over the past 25 years. There were a number of transformations resulting from, or accelerated by, this change including the 1) intensification of well construction causing a redistribution in access to groundwater, water shortages and a lowering of the groundwater table; 2) expansion of irrigation into former rain-dependent uphill areas resulting in increased water use; 3) shift to higher- value monoculture fruit crops, but with associated higher crop water requirements; 4) in…

Una más de la familia. Au pairs atrapadas entre el capital humano y la economía moral

2018

In contemporary societies we are witnessing an expansion of the messages of human capital. These messages have as their central dimension idea of the self-entrepreneur, which implies a deepening in the logic of activation, while blurring the wage relations. In this scenario, young people with university degrees are becoming a favourite target in the offensive of human capital. The penetration of these human capital messages can be seen in the discourses of young university students who have been forced to leave the country during the crisis. In the present text we approach the discourses of young women who came out as au pairs. The characteristics of this figure place it in a space halfway …

Expansión urbana del Área Metropolitana de Valencia en el periodo 1984-2011 a partir de imágenes Landsat TM y ETM+

2015

La expansión urbana acelerada producida en décadas recientes en las grandes áreas metropolitanas como Valencia conlleva importantes impactos ambientales, entre ellos la impermeabilización o "sellado antropogénico" del suelo y la pérdida de espacios naturales de gran valor paisajístico. Este trabajo analiza la evolución de la cobertura artificial en el Área Metropolitana de Valencia (AMV) en el periodo 1984-2011 a partir de imágenes Landsat TM y ETM+, validadas a partir de datos SIOSE de mayor resolución espacial. Los resultados muestran, con una precisión del 71%, un aumento de la superficie artificial en el AMV de 8000 ha en dicho periodo, lo que supone un incremento del 10% del suelo sell…