Search results for "EXPRESSION"

2015

Myoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in different cancer entities. 40% of breast tumors are MB-positive, with the globin being co-expressed with markers of tumor hypoxia in a proportion of cases. In breast cancer, MB expression is associated with a positive hormone receptor status and patient prognosis. In prostate cancer, another hormone-dependent cancer type, 53% of tumors were recently shown to express MB. Especially in more aggressive prostate cancer specimen MB expression also correlates with increased patient survival rates. Both findings might be due to tumor-suppressing properties of MB in cancer cells. In contrast to muscle, MB tr…

STUDIO DELLA BIODISTRIBUZIONE DI SOSTANZE BIOLOGICAMENTE ATTIVE IN ORGANISMI ACQUATICI

2022

Condensation of classical optical waves beyond the cubic nonlinear Schrodinger equation

2012

International audience; A completely classical nonlinear wave is known to exhibit a process of condensation whose thermodynamic properties are analogous to those of the genuine Bose-Einstein condensation. So far this phenomenon of wave condensation has been studied essentially in the framework of the nonlinear Schrodinger (NLS) equation with a pure cubic Kerr nonlinearity. We study wave condensation by considering two representative generalizations of the NLS equation that are relevant to the context of nonlinear optics, the nonlocal nonlinearity and the saturable nonlinearity. For both cases we derive analytical expressions of the condensate fraction in the weakly and the strongly nonlinea…

PTHrP [38-94] and gene expression of MDA-MB231 breast cancer cells

2006

The expression of PTHrP isoforms in differentiating human fat-derived mesenchymal stem cells

2012

PTHrP isoform expression in adipo- and osteo-differentiating human mesenchymal stem cells

2011

Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNA s

2018

Abstract Learning is essential for survival and is controlled by complex molecular mechanisms including regulation of newly synthesized mRNAs that are required to modify synaptic functions. Despite the well‐known role of RNA‐binding proteins (RBPs) in mRNA functionality, their detailed regulation during memory consolidation is poorly understood. This study focuses on the brain function of the RBP Gadd45α (growth arrest and DNA damage‐inducible protein 45 alpha, encoded by the Gadd45a gene). Here, we find that hippocampal memory and long‐term potentiation are strongly impaired in Gadd45a‐deficient mice, a phenotype accompanied by reduced levels of memory‐related mRNAs. The majority of the Ga…

Movements by Drawing: Avant-Garde Set-Design and Sound Landscapes

2018

The article deals with the study of visual images produced by the movement through the drawing’s set-design realized between 1920 and 1930, moment of theatre revolution, which saw the cooperation of different sectors of art, including photography, painting, architecture, cinema, dance, sculpture, and music. The visual values that triggered the theorization of the artistic avant-garde and, subsequently, the production of the scenographic drawing, in form and space, constitute a corollary of dynamic systems, a metaphor of the deconstructed movement through the figuration of the idea and at the same time signification of the interpretative distortion. The aim is to deepen the issue of movement…

Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells

2010

Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. Despite an increase in the number of systemic treatments available for pancreatic cancer, the impact of therapy on the clinical course of the disease has been modest, underscoring an urgent need for new therapeutic options. Although selective cyclooxygenase-2 inhibitors have been demonstrated to have cancer-preventive effects, the mechanism of their effects is not clearly known. Moreover, there have been no unbiased studies to identify novel molecular targets of NS-398 regarding pancreatic cancer. Here we undertook a gene expression profiling study to identify novel molecular targets m…

Do historical sediments of pulp and paper industry contribute to the exposure of fish caged in receiving waters?

2011

Field experiments were conducted in early summer 2004 by caging brown trout (Salmo trutta m. lacustris) in Southern Lake Saimaa (SE Finland) for 10 days. Cages were positioned into two depths at four distances (5 to 17 km) from the pulp and paper mill; one set with direct contact to the sediment and other locating at the three meters' depth from the water surface. Resin acids were measured from sediment, water, and fish bile. Possible toxicities were investigated by measuring liver EROD-activity, HSP70-protein, and gene expression profiles by microarray. The concentration of resin acids in the sediment showed clear gradient along the distance from the mill, and their concentrations in water…