Search results for "EXPRESSION"

Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD

2021

Background and aim: Coffee intake exerts protective effects against non-alcoholic fatty liver disease (NAFLD), although without fully cleared mechanisms. In this study we aimed to assess whether coffee consumption may influence the expression of long non-coding RNAs (lncRNAs) in the liver. Methods: C57BL/6J mice were fed a 12-week standard diet (SD), high-fat diet (HFD) or HFD plus decaffeinated coffee solution (HFD + coffee). Expression of specific lncRNAs involved in NAFLD was analyzed by real-time PCR. For the most differentially expressed lncRNAs, the analysis was also extended to their mRNA targets. Results: Decaffeinated coffee intake reduced body weight gain, prevented NAFLD, lowered…

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configurati…

2020

mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in Saccharomyces cerevisiae. We found significant effects of Xrn1 perturbation on RNA pol II profiles across the genome. RNA pol II profiles at 5ʹ exhibited significant alterations that were com…

Automatic Processing of Changes in Facial Emotions in Dysphoria: A Magnetoencephalography Study

2018

It is not known to what extent the automatic encoding and change detection of peripherally presented facial emotion is altered in dysphoria. The negative bias in automatic face processing in particular has rarely been studied. We used magnetoencephalography (MEG) to record automatic brain responses to happy and sad faces in dysphoric (Beck’s Depression Inventory ≥ 13) and control participants. Stimuli were presented in a passive oddball condition, which allowed potential negative bias in dysphoria at different stages of face processing (M100, M170, and M300) and alterations of change detection (visual mismatch negativity, vMMN) to be investigated. The magnetic counterpart of the vMMN was el…

Logos’ Centrality and Expression in Martyria as a Superior Form of Dialogue

2021

This paper describes some motivations and outlines some limits regarding the possibility and necessity of interreligious, interconfessional, and interideological dialogue, in an attempt to improve our understanding of Orthodox Christianity’s role in these important aspects of domestic and foreign politics. This study aims to resolve the divergent opinions that exist in the Orthodox Church regarding the possibility of remaining in this kind of dialogue. The ancient philosophical mode of dialogue and the modern one are analyzed: dialogue as debate and negotiation. The study begins from the analysis of some technical terms describing the social and spiritual dimensions of dialogue

Alterations in working memory maintenance of fearful face distractors in depressed participants : An ERP study

2023

Task-irrelevant threatening faces (e.g., fearful) are difficult to filter from visual working memory (VWM), but the difficulty in filtering non-threatening negative faces (e.g., sad) is not known. Depressive symptoms could also potentially affect the ability to filter different emotional faces. We tested the filtering of task-irrelevant sad and fearful faces by depressed and control participants performing a color-change detection task. The VWM storage of distractors was indicated by contralateral delay activity, a specific event-related potential index for the number of objects stored in VWM during the maintenance phase. The control group did not store sad face distractors, but they automa…

Liikeanalyysi masentuneiden ja ei-masentuneiden musiikista havaitsemien perustunteiden ilmaisusta liikkeessä

2013

Leinonen, Outi (2013). Liikeanalyysi masentuneiden ja ei-masentuneiden musiikista havait-semien perustunteiden ilmaisusta liikkeessä. Liikuntakasvatuksen laitos, Jyväskylän yliopisto, liikuntapedagogiikan pro gradu -tutkielma, 67 s., 2 liitettä. Tunteet, niiden säätely ja tarkoituksenmukainen ilmaisu ovat yhteydessä ihmisen kokonais-valtaiseen hyvinvointiin. Mielenterveyshäiriöistä kärsivillä on usein vaikeuksia tunneviestin-nässä. Esimerkiksi masentuneilla on vaikeuksia tunnistaa ja ilmaista tunteita. Masennus on yksi suurimpia kansanterveydellisiä ongelmia Suomessa, etenkin nuorilla. Nuoruusiässä puh-jennut masennus vaikuttaa pitkälle nuoren tulevaisuuteen kielteisesti. Tämän tutkimuksen …

My emotions expressed by music

2014

Improvisational psychodynamic music therapy (IPMT) has been demonstrated by Erkkilä et al. (2011) to be effective in the treatment for people suffering from depression. For the purpose of a mixed methods research design all musical improvisations have been captured electronically, the therapist’s notes have been standardized, and the sessions have been recorded and saved. Furthermore, the research team of the university of Jyväskylä has developed a computational analysis software, called Music Therapy Toolbox (MTTB). The purpose of this master’s thesis was to investigate two improvisations from one case in-depth, through the use of the MTTB software. The findings are presented, as well as t…

Brain's change detection elicited by emotional facial expressions in depressed and non-depressed individuals

2009

Vladimír Nabokov a jeho román "Pozvání na popravu" jako skryté poselství o lidském poznání zašifrované v důmyslných gnostických metaforách archetypic…

2015

Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta.

1998

The cDNA of the microsomal Juvenile Hormone Epoxide Hydrolase (JHEH) from Manduca sexta was expressed in vitro in the baculovirus system. In insect cell culture, the recombinant enzyme (Ms-JHEH) was produced at a high level (100 fold over background EH catalytic activity). As expected, Ms-JHEH was localized in the microsomal fraction with a molecular mass of approximately 50 kDa. Ms-JHEH showed a substrate and inhibitor spectrum similar to the wild type JHEH isolated from eggs of M. sexta. Its enzymatic activity was the highest for Juvenile Hormone III. Ms-JHEH hydrolyzed several trans-epoxides faster than cis-epoxides. A putative hydroxyl-acyl enzyme intermediate was isolated suggesting a …