Search results for "Ebola"
showing 10 items of 18 documents
Understanding the Health Disaster: Research Design for the Response to the 2014 West African Ebola Outbreak
2015
International audience; The 2014 Ebola outbreak in West Africa is the largest ever in history, affecting multiple countries and to this date, the World Health Organization has registered more than 6,500 deaths attributed to Ebola. The challenges arising from this outbreak to responders worldwide do not follow the standard characterisation or response patterns of natural sudden onset vs. conflict disasters. Rather, it is a medical emergency, which is intertwined with multiple challenges in the sectors decision-making, coordination, logistics and information management. In this paper, we present our research framework, which is based on desk research and initial interviews with responders. Th…
Chaperoning the Mononegavirales: Current Knowledge and Future Directions
2018
This article belongs to the Special Issue Breakthroughs in Viral Replication.
Ebola: an open letter to European governments.
2014
After months of inaction and neglect from the international community, the Ebola epidemic in west Africa has now spiralled utterly out of control. Today, the virus is a threat not only to the countries where the outbreak has overwhelmed the capacity of national health systems, but also to the entire world. We urge our governments to mobilise all possible resources to assist west Africa in controlling this horrific epidemic. Based on our expertise in public health and emergency response, we believe the following measures would be particularly eff ective. First, with regards to human resources, given the huge need for trained health-care professionals in west Africa, we urge European governme…
Culture of fear, age of anxiety : case of the Ebola outbreak in 2014
2017
Tämä gradu tutkii miten 2014 Ebola epidemiaa Länsi-Afrikassa kuvailtiin länsimaisessa mediassa, sekä sitä miten nämä kuvaukset liittyvät vallitsevaan pelon kulttuuriin. Pelon kulttuuri viittaa viime vuosikymmeninä länsimaissa kasvaneeseen ilmiöön, jossa pelosta on tullut vallitseva osa jokapäiväistä elämää jonka kautta maailmaa ymmärretään. Sosiologien Frank Furedi (2002), Barry Glassner (1999) and David Altheide (2006) tutkimukset pelon kulttuurista muodostavat teoreettisen viitekehyksen tälle tutkimukselle. Aineistoni koostuu englantilaisten The Guardian and Daily Mail lehtien Ebolaa käsittelevistä artikkeleista. Tutkimusmetodina on käytetty kvalitatiivista sisällönanalyysiä, sekä joitain…
Impact of Ebola outbreak on reproductive health services in a rural district of Sierra Leone: a prospective observational study
2019
ObjectivesTo assess the trends concerning utilisation of maternal and child health (MCH) services before, during and after the Ebola outbreak, quantifying the contribution of a reorganised referral system (RS).DesignA prospective observational study of MCH services.SettingPujehun district in Sierra Leone, 77 community health facilities and 1 hospital from 2012 to 2017.Main outcome measuresMCH utililization was evaluated by assessing: (1) institutional deliveries, Cesarean-sections, paediatric and maternity admissions and deaths, and major direct obstetric complications (MDOCs), at hospital level; (2) antenatal care (ANC) 1 and 4, institutional delivery and family planning, at community leve…
When local gets a global focus : Ebola outbreak narratives in Toronto Star in 2014 - 2015
2016
Gradussani 'Kun paikallinen saa globaalin fokuksen: Ebolan leviämisen narratiivit vuosina 2014 – 2015 Toronto Star -lehdessä' tutkin otsikon mukaisesti Ebolan leviämisen narratiiveja viimeisimmän Ebolaepidemian ajalta. Toronto Star on Kanadan suurin päivittäin ilmestyvä sanomalehti, jonka julkaisupaikka on Torontossa Ontarion provinssissa. Teoreettisena viitekehyksenä käytän Melissa Leachin vuonna 2008 kehittelemää temaattisten narratiivien kategorisointia verenvuotokuumeista (esimerkiksi Ebola ja Marburgin virus). Hänen kategorisointi sisältää seuraavat narratiivit: (1) Globaali uhka: Afrikasta nousevaa ruttoa vastaan taisteleminen, (2) Tappavat paikalliset sairaustapaukset: globaali nopea…
Ebola Virus Disease Complicated by Late-Onset Encephalitis and Polyarthritis, Sierra Leone
2016
To the Editor: Ebola virus (EBOV) disease is usually an acute illness, but increasing evidence exists of persistent infections and post-Ebola syndromes. We report a case of EBOV encephalitis.
The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
2021
Summary Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths. EBOV glycoprotein (EBOV-GP) is the only viral surface protein and is responsible for viral entry into cells. Here, by employing pseudotyped EBOV-GP viral particles, we uncover a critical role for sphingolipids in inhibiting viral entry. Sphingosine kinase 1 (SphK1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P). The administration of the SphK1 activator, K6PC-5, or S1P, or the overexpression of SphK1 consistently exhibited striking inhibitory effects in EBOV-GP-driven entry in diverse cell lines. F…
Chaperoning the <em>Mononegavirales</em>: Current Knowledge and Future Directions
2018
The order Mononegavirales harbors numerous viruses of significant relevance for human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Therefore, targeting cellular pathways used by viruses can provide novel therapeutic approaches. One of the key challenges confronted by both hosts and viruses alike is the successful folding and maturation of proteins. In cells, this task is faced by cellular molecular chaperones, a group of conserved and abundant proteins…
Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein
2004
AbstractThe structural determinants underlying the functionality of viral internal fusion peptides (IFPs) are not well understood. We have compared EBOwt (GAAIGLAWIPYFGPAAE), representing the IFP of the Ebola fusion protein GP, and EBOmut (GAAIGLAWIPYFGRAAE) derived from a non-functional mutant with conserved Pro537 substituted by Arg. P537R substitution did not abrogate peptide-membrane association, but interfered with the ability to induce bilayer destabilization. Structural determinations suggest that Pro537 is required to preserve a membrane-perturbing local conformation in apolar environments.