Search results for "Edema"
showing 10 items of 625 documents
Co-administration of pentoxifylline and thiopental causes death by acute pulmonary oedema in rats
2006
Background and purpose: Pentoxifylline exhibits rheological properties that improve microvascular flow and it is widely used in vascular perfusion disorders. It also exhibits marked anti-inflammatory properties by inhibiting tumour necrosis factor a production. Thiopental is one of the most widely used drugs for rapid induction of anaesthesia. During experimental studies on the treatment of acute pancreatitis, we observed that when pentoxifylline was administered after anaesthesia with thiopental, most of the rats exhibited dyspnea, signs of pulmonary oedema and died. The aim of the work described here was to investigate the cause of the unexpected toxic effect of the combined treatment wit…
In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation.
2000
The pseudoguaianolide sesquiterpene lactones 4-alpha-O-acetyl-pseudoguaian-6beta-olide (1), hymenin (2), ambrosanolide (3), tetraneurin A (4), parthenin (5), hysterin (6) and confertdiolide (7) were evaluated for their ability to affect the inflammation responses induced by different agents. All the compounds showed activity against the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema. The ethyl phenylpropiolate (EPP)-induced mouse ear edema was inhibited by compounds 3, 5 and 7. However, when sesquiterpene-lactones were assayed on the arachidonic acid (AA)-induced mouse ear edema, none of them were active. The only sesquiterpene lactone orally active against the paw mouse…
Die Beeinflussung eines experimentellen Stauungs�dems der Ratte durch Chlorothiazid, Hydrocortison, Dexamethason, DOCA und Vasopressin
1960
Experiments on rats were made to determine which drugs were capable of preventing the formation of an experimental obstruction edema.
The Tolerability of Nilvadipine Compared to Nifedipine in Patients with Essential Hypertension
1992
In one multicenter, double-blind study, 659 hypertensive patients were treated for 16 weeks with either nilvadipine (n = 326) or nifedipine (n = 333). The major objective of the study was to compare the compatibility of the two calcium antagonists with regard to hepatic compatibility and side-effect profiles. The dosages were chosen so that the effective blood pressure reduction in both groups was equally good (mean decreases in systolic pressure of 27 +/- 12 mm Hg with nilvadipine and 26 +/- 15 mm Hg with nifedipine, and in diastolic pressure of 18 +/- 6 mm Hg with nilvadipine and 19 +/- 7 mm Hg with nifedipine). The mean heart rate was slightly lowered by about 2 beats/min by both substan…
Die Wirkung von Oxytocin auf die renale Ausscheidung und auf die Ausbildung eines Stauungs�dems bei der Ratte
1960
1. An experimental congestion edema was produced in rats by tying of both jugular veins. During 22 hours after the operation the animals were loaded three times with 5 ml./100 g body weight 0,9% saline per os. Each animal received 1000 mU/kg. Syntocinon s.c. one half hour before each fluid loading.
Current drugs in early development for hereditary angioedema: potential for effective treatment
2014
Hereditary angioedema (HAE) through C1 inhibitor deficiency is a rare but important disease. It is characterized by recurrent episodes of angioedema, which commonly affects the skin (in the form of swelling in the extremities, face and genitals) as well as the gastrointestinal tract (abdominal pain attacks). In approximately 1% of cases of angiodema-related swelling, there is obstruction of the upper airway, which is potentially life-threatening. Therefore, HAE due to C1 inhibitor deficiency may be associated with significant morbidity and mortality. Recent research has added to our ever-increasing understanding of the pathogenesis of HAE, which has, in addition, new clinical trials with ne…
Die Ausbildung verschieden starker Stauungs�deme bei der Ratte und ihre Beseitigung durch Chlorothiazid
1960
1. After tying of the jugular veins a congestion edema of differing intensity was produced by oral loading of rats with varying amounts of saline. 2. Chlorothiazid (10 or 50 mg./kg. i.v.) given 24 hours after tying of the jugular veins increased the diuresis and sodium excretion to approximately the same values in edematous and normal animals. 3. The effect of chlorothiazid on renal excretion is not influenced by the severity of the edema and is not quantitatively related to reduction of edema.
Thermal Transport and Wiedemann-Franz Law in the Disordered Fermi Liquid
2014
We study thermal transport in the disordered Fermi liquid at low temperatures. Gravitational potentials are used as sources for finding the heat density and its correlation function. For a comprehensive study, we extend the renormalization group (RG) analysis developed for electric transport by including the gravitational potentials into the RG scheme. Our analysis reveals that the Wiedemann-Franz law remains valid even in the presence of quantum corrections caused by the interplay of diffusion modes and the electron electron interaction. In the present scheme this fundamental relation is closely connected with a fixed point in the multi-parametric RG-flow of the gravitational potentials.
Violation of the Wiedemann-Franz Law in HF Metals
2014
Experimental observations of the much-studied compounds CeCoIn\(_5\) and YbRh\(_2\)Si\(_2\) at vanishing temperatures carefully probe the nature of their magnetic-field-tuned QCPs. The violation of Wiedemann-Franz (WF) law, along with jumps revealed both in the residual resistivity \(\rho _0\) and the Hall resistivity \(R_H\), provide vital clues to the origin of their non-Fermi-liquid behavior. The empirical facts point unambiguously to association of the observed QCP with FC forming flat bands.
Possible Role of Glymphatic System of the Brain in the Pathogenesis of High-Altitude Cerebral Edema
2018
Simka, Marian, Paweł Latacz, and Joanna Czaja. Possible role of glymphatic system of the brain in the pathogenesis of high-altitude cerebral edema. High Alt Med Biol. 19:394–397, 2018.—In this article, we suggest that the glymphatic system of the brain can play an important role in the pathogenesis of high-altitude cerebral edema (HACE). Water enters the intercellular space of the brain primarily through aquaporin-4 (AQP-4) water channels, the main component of the glymphatic system, whereas acetazolamide, pharmacological agent used in the prevention of HACE, is the blocker of the AQP-4 molecule. In animal experiments, cerebral edema caused by hypobaric hypoxia was associated with an increa…