Search results for "Edrophonium"

showing 3 items of 3 documents

Ocular pseudomyasthenia: report of a case with a pineal region tumor.

1991

A case presenting with clinical features of ocular myasthenia and a false-positive edrophonium test is reported. Brain CT and MRI scan revealed a pineal region tumor histologically verified as germinoma. We recommend evaluating patients with clinical features of myasthenia gravis (MG) confined to the ocular muscles for intracranial mass lesions.

AdultMalemedicine.medical_specialtyPathologyNeurologyPineal regionOcular myastheniaDermatologyEdrophoniumDysgerminomaPineal GlandMyasthenia GravisDiplopiaMedicineHumansNeuroradiologyGerminomabusiness.industryBrain NeoplasmsGeneral NeurosciencePupilGeneral Medicinemedicine.diseaseMagnetic Resonance ImagingMyasthenia gravisnervous system diseasesPsychiatry and Mental healthOculomotor MusclesEvoked Potentials VisualNeurology (clinical)NeurosurgeryVisual FieldsbusinessTomography X-Ray Computedmedicine.drugItalian journal of neurological sciences
researchProduct

Anorectal function and morphology in patients with sporadic proctalgia fugax

1996

PURPOSE: The pathophysiology of sporadic proctalgia fugax remains unknown. This study investigates whether patients with this syndrome exhibit alterations in anal function and morphology. METHODS: Eighteen patients with sporadic proctalgia fugax and 18 sex-matched and age-matched healthy controls were studied. Manometric studies investigated anal resting and squeeze pressures, the rectoanal inhibitory reflex, rectal compliance, and smooth muscle response to edrophonium chloride administration. External and internal sphincter thickness was measured endosonographically. RESULTS: Patients had slightly higher (P=0.0291) anal resting pressures (65.5±11.4 mmHg) than controls (56±9.9 mmHg). Howeve…

AdultMalemedicine.medical_specialtyProctalgia fugaxManometryAnal CanalRectumGastroenterologyEdrophonium ChlorideInternal anal sphincterInternal medicineHumansMedicineAgedUltrasonographybusiness.industryUrethral sphincterRectumGastroenterologyMuscle SmoothGeneral MedicineMiddle Agedmedicine.diseasePathophysiologySurgeryRectal Diseasesmedicine.anatomical_structureCase-Control StudiesReflexNeuralgiaSphincterFemalebusinessDiseases of the Colon & Rectum
researchProduct

Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet.

2009

In this study the development of a procedure based on capillary electrophoresis after enzymatic reaction at capillary inlet methodology for the screening and in vitro evaluation of the biological activity of acetylcholinesterase (AChE) inhibitors is presented. The progress of the enzymatic reaction of the hydrolysis of acetylthiocholine at pH 8 in the presence of AChE and the inhibitor studied is determined by measuring at 230 nm the peak area of the reaction product thiocholine (TCh). In the method employed the capillary was first filled with 30 mM borate-phosphate buffer (pH 8.0) and subsequently, plugs of: (i) water, (ii) AChE solution, (iii) substrate solution with or without inhibitor,…

ChromatographyTime FactorsbiologyHydrolysisSubstrate (chemistry)Electrophoresis CapillaryFiltration and SeparationEdrophoniumAcetylcholinesteraseAnalytical ChemistryEnzyme Activationchemistry.chemical_compoundKineticsThiocholineCapillary electrophoresisNon-competitive inhibitionchemistryEnzyme inhibitorAcetylthiocholinemedicinebiology.proteinAcetylcholinesteraseCholinesterase InhibitorsSoftwaremedicine.drugJournal of separation science
researchProduct