Search results for "Effectivene"
showing 10 items of 373 documents
O-18 - TDM in patients with substance related disorders
2012
The effect of pharmacotherapy of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve the outcomes. Since TDM for these drugs is not well established, the authors built a literature based rating scale to evaluate the necessity of TDM for the use of these pharmacological agents. Methods A literature research was performed for acamprosate, bupropion, buprenorphine, clomethiazole, disulfiram, methadone, naltrexone, and varenicline. A rating scale including 22 items, divided in five categories (efficacy, toxicity, pharmacokinetics, patient characteristics and cost effectiveness) was established for evaluation and related to the amo…
Therapeutic drug monitoring of drugs for treatment of substance-related disorders
2011
IntroductionThe effect of pharmacotherapy of substance-related disorders is moderate at best.ObjectivesTherapeutic drug monitoring (TDM) could be an instrument to improve the outcomes. TDM is for most of these drugs not established yet.AimsThe authors built a literature based rating scale to evaluate the necessity of TDM for these pharmacological agents.MethodsA literature research was performed for TDM related properties of acamprosate, bupropion, buprenorphine, clomethiazole, disulfiram, methadone, naltrexone, and varenicline. A rating scale was established for evaluation. It included 28 items related to five categories (efficacy, toxicity, pharmacokinetics, patient characteristics and co…
Estimation of measures of effectiveness (MOE) for the C- Roundabouts
2013
The C-roundabout (cyclist roundabout) is a new multi-lane roundabout designed to improve the safety of cyclists at and make multi-lane roundabouts more cyclist-friendly. The geometric layout of C-Roundabouts allows the decrease of the vehicle speeds through the roundabout to around 30 km/h. The rare C-roundabout installations so far implemented in the world have not allowed analysing the capacity by means empirical data. In the light of this considerations, the main objective of the paper is to give a theoretical closed-form model for evaluation the measures of effectiveness “MOE” (capacity, delay, queues) of the C-Roundabouts.
Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe
2020
Purpose Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale. Methods Survey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health–funded organization. Responses were analyzed to measure trends and regional subtleties about patient oncofertility experiences and to analyze barriers to care at sites that provide oncofertility services. Results Sixty-three res…
Response of Chinese Hamster V79 Multicellular Spheroids Exposed to High-Energy Carbon Ions
2004
Chinese hamster V79-379A spheroids 200 +/- 30 microm (+/- SD) in diameter were irradiated in agitated medium in different oxygen atmospheres with (1) 227 MeV/nucleon (12)C(+6) ions (plateau region) to model tissue in the entrance channel during therapy, (2) carbon ions in the extended Bragg peak modeling tissue in the target volume, or (3) X rays as a reference modality. Cell survival curves were similar for modes (1) and (3), indicating the absence of a contact effect and the presence of a pronounced oxygen effect with oxygen enhancement ratios (OERs) of 2.8 and 2.9, respectively. In contrast, the oxygen effect was substantially smaller in mode (2) with an OER of 1.4. Under normal or restr…
Investigating Aid Effectiveness in Developing Countries: The Case of Nepal
2020
Foreign aid serves as an important source of capital for any developing or under-developed country. It is very important to see how the recipient country can utilize this aid in the economic upliftment of the nation. Taking a case of Nepalese economy, this paper investigates the effectiveness of foreign aid in developing countries. The result from Johansen’s cointegration test reveals that foreign aid independently is not adequate for the economic growth. Increased capital and technological infrastructures, improved skills on human capital, on the other hand, significantly changes the result for the positive aid impact on growth in the long run. Therefore, we can conclude that a good policy…
The Global Research Collaboration of Network Meta-Analysis: A Social Network Analysis
2016
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Comportamentos de suporte e eficácia grupal: o papel mediador dos comportamentos de aprendizagem
2018
Dissertação de Mestrado em Psicologia do Trabalho, das Organizações e dos Recursos Humanos apresentada à Faculdade de Psicologia e de Ciências da Educação Supportive behaviours, defined “as the extent to which team members voluntarily provide assistance to each other when needed during task accomplishment” (Aubé & Rousseau, 2005, p.193), constitute a determinant of Team Effectiveness (Dimas, Rocha, Rebelo, & Lourenço, 2016). The current research aims to clarify further the relationship between Supportive Behaviours and Team Effectiveness criteria, mediated by Team Learning Behaviours. Based on the model of effectiveness Input-Mediator-Outcome-Input (IMOI) from Kozlowski and Ilgen (2006), th…
Validating retinal fundus image analysis algorithms: issues and a proposal.
2013
This paper concerns the validation of automatic retinal image analysis (ARIA) algorithms. For reasons of space and consistency, we concentrate on the validation of algorithms processing color fundus camera images, currently the largest section of the ARIA literature. We sketch the context (imaging instruments and target tasks) of ARIA validation, summarizing the main image analysis and validation techniques. We then present a list of recommendations focusing on the creation of large repositories of test data created by international consortia, easily accessible via moderated Web sites, including multicenter annotations by multiple experts, specific to clinical tasks, and capable of running …
Robustness of 40 Gb/s ASK modulation formats in the practical system infrastructure.
2006
In this work, we analyzed by means of numerical and laboratory experiments the resilience of 40 Gb/s amplitude shift keying modulation formats to transmission impairments in standard single-mode fiber lines as well as to optical filtering introduced by the optical add/drop multiplexer cascade. Our study is a pre-requisite to assess the implementation of cost-effective 40 Gb/s modulation technology in next generation high bit-rate robust optical transport networks. © 2006 Optical Society of America.