Search results for "Effects"
showing 10 items of 2634 documents
X-ray diffraction measurements of Mo melting to 119 GPa and the high pressure phase diagram
2009
In this paper, we report angle-dispersive X-ray diffraction data of molybdenum melting, measured in a double-sided laser-heated diamond-anvil cell up to a pressure of 119 GPa and temperatures up to 3400 K. The new melting temperatures are in excellent agreement with earlier measurements up to 90 GPa that relied on optical observations of melting and in strong contrast to most theoretical estimates. The X-ray measurements show that the solid melts from the bcc structure throughout the reported pressure range and provide no evidence for a high temperature transition from bcc to a close-packed structure, or to any other crystalline structure. This observation contradicts earlier interpretation…
Dietary l-tryptophan leaves a lasting impression on the brain and the stress response
2017
AbstractComparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic sa…
Convergence of Theory and Experiment on the Role of Preorganization, Quantum Tunneling, and Enzyme Motions into Flavoenzyme-Catalyzed Hydride Transfer
2017
Hydride transfer is one of the most common reactions catalyzed by enzymatic systems, and it has become an object of study because of possible significant quantum tunneling effects. In the present work, we provide a combination of theoretical QM/MM simulations and experimental measurements of the rate constants and kinetic isotopic effects (KIEs) for the hydride transfer reaction catalyzed by morphinone reductase, MR. Quantum mechanical tunneling coefficients, computed in the framework of variational transition-state theory, play a significant role in this reaction, reaching values of 23.8 ± 5.5 for the lightest isotopologue—one of the largest values reported for enzymatic systems. This pred…
Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of at…
2014
International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…
Adverse side effects of statins in the oral cavity
2008
Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117363
Spatial beam cleaning in quadratic nonlinear medium
2018
We show experimentally that a laser beam scrambled by propagation in a short segment of multimode fiber may be cleaned by the nonlinear propagation in KTP cristal with type-II second-harmonic generation.
Estimation of the Amount of Disposed Antibiotics
2019
The impact of the antibiotics in the environment is not well understood yet. Moreover, the total amount of antibiotics that are ending up in the environment as solid waste is not known and cannot be rigorously determined as many variables are influencing the determination of their concentration. The present article is focused on the estimation of the amount of non-prescribed antibiotics that are used in different European countries. Particular attention is paid to the class of beta-lactams, as they are responsible for a considerate share of the antimicrobial resistance. The primary purpose was the estimation of the quantity of non-prescribed antibiotics that might reach the environment as s…
Determination of selected phthalates by gas chromatography–mass spectrometry in mural paintings from Palermo (Italy)
2013
Abstract Phthalate esters for decades, and probably even now, were used as softeners in water-based paintings. In general, these compounds are dangerous owing to their carcinogenicity and reproductive effects. Phthalates are not chemically but only physically bound to the matrices, hence, they may be leached into the environment and are ubiquitously found in environmental matrices. Considering that, construction is one of most important fields in Europe, and probably worldwide, with respect to its economic, technological and environmental impact. In the present work the phthalate esters content of several mural paintings was evaluated by gas chromatography–mass spectrometry (GC-MS). Because…
Mycochemicals in wild and cultivated mushrooms: nutrition and health
2021
AbstractThe mushrooms have contributed to the development of active ingredients of fundamental importance in the field of pharmaceutical chemistry as well as of important tools in human and animal health, nutrition, and functional food. This review considers studies on the beneficial effects of medicinal mushrooms on the nutrition and health of humans and farm animals. An overview of the chemical structure and composition of mycochemicals is presented in this review with particular reference to phenolic compounds, triterpenoids and sterols, fatty acids and lipids, polysaccharides, proteins, peptides, and lectins. The nutritional value and chemical composition of wild and cultivated mushroom…
Untangling the roles of low skill and education in predicting youth NEET statuses: negative signalling effects in comparative perspective
2021
International audience; Education determines life chances across the globe, but human capital and skill formation offer context-specific advantages in the labour market during the transition from school to work. Our study focuses specifically on the varying effects of low skill on youth ‘not in employment, education or training’ (NEET) statuses via educational attainments. Using Programme for the International Assessment of Adult Competencies (PIAAC) data, we estimate the extent to which country-specific relative low skill levels affect young people’s probability of reporting long-term NEET statuses across contexts. We find that low skill and education have differing effects on the probabil…