Search results for "Effects"
showing 10 items of 2634 documents
A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial
2021
Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. Objective: To describe the occurrence of adverse events in PD patients treated with safinamide in real-life conditions. Methods: The SYNAPSES trial is an observational, European, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months with analyses performed in the overall population and in patients aged >75 years, with relevant comorbi…
Ensuring Effective Prevention of Iodine Deficiency Disorders
2016
To access publisher's full text version of this article click on the hyperlink at the bottom of the page Programs initiated to prevent iodine deficiency disorders (IDD) may not remain effective due to changes in government policies, commercial factors, and human behavior that may affect the efficacy of IDD prevention programs in unpredictable directions. Monitoring and outcome studies are needed to optimize the effectiveness of IDD prevention. Although the need for monitoring is compelling, the current reality in Europe is less than optimal. Regular and systematic monitoring surveys have only been established in a few countries, and comparability across the studies is hampered by the lack o…
A New Methodology to Assess Territorial Competence for Sustainable Local Development: The READI® (Resources-Actors-Dynamics) Matrix
2021
[EN] The ability of a territory to manage certain sustainable development processes increasingly depends on its capacity to apply previous diagnostic processes to its current situation. For this reason, methodologies that facilitate the detection of needs and/or potentialities of the territory are key to meeting its anticipated sustainable development goals. We present the most notable results of the research methodology carried out in the province of Valencia (Spain) that has enabled the construction of a matrix of indicators that allow these previous diagnostic processes to be put into practice at a local level, based on the participation of the territory's socioeconomic actors.
Association between odour pollution from industrial sources and human health: a systematic review and meta-analysis
2021
Objetivo: Se realizó una revisión sistemática para sintetizar toda la evidencia disponible, de estudios epidemiológicos, sobre la asociación entre la exposición residencial u ocupacional a corto y largo plazo a la contaminación por mal olor industrial y el estado de salud de la población expuesta. Métodos: Las búsquedas bibliográficas se realizaron en OvidMedline, EMBASE y Scopus en octubre de 2018. Para la exposición, se incluyeron estudios si capturaban la exposición a un olor ambiental de origen industrial en el ámbito residencial u ocupacional. Se consideraron los resultados para los cuales había una plausibilidad biológica, como fueron sibilancias y asma, tos, cefalea, náuseas y vómito…
Desalination. From a questioned resource to a necessary and strategic resource during drought situations for the water supply in the Segura River Bas…
2018
En España, la desalinización ha cobrado un gran impulso en las dos últimas décadas gracias a la aprobación en 2001 del Plan Hidrológico Nacional y en 2004 del Programa A.G.U.A. Ello ha sido motivado por dos factores principales: 1) Las recurrentes e intensas sequías en las últimas décadas, en especial, la de los años noventa en la que se puso de manifiesto la necesidad de la búsqueda de nuevas fuentes y la apuesta por los recursos hídricos no convencionales (desalinización y aguas regeneradas depuradas); y 2) Cambio del antiguo paradigma hidráulico basado en el incremento de la oferta mediante las transferencias de aguas. El objetivo de esta investigación es analizar el rol que ha desempeña…
Urban Stormwater Management, A Tool for Adapting to Climate Change: From Risk to Resource
2020
The effects of climate change on rainfall in the Mediterranean region are manifested in an overall decreasing trend, and greater irregularity in annual volumes and the city of Alicante is no exception. In addition, there has also been a spread of the urbanised area, which has led to an increase in the flood risk in urban areas (due to a greater runoff and the occupation of flood hazard areas) and drought events due to an increase in the water demand. In light of these new scenarios, the Mediterranean cities should design adaptation systems based on rainwater harvesting within the framework of a circular economy. This study analyses the integration of rainwater in flood and water demand mana…
Promoting Food Waste Reduction at Primary Schools. A Case Study
2021
Food waste (FW) has recently attracted the interest of different institutions and has been the focus of many studies due to its important environmental, social and economic impact. This paper aims to analyze whether a didactic intervention, consisting of informing teachers and pupils and involving pupils in reducing FW, could bring about changes in the level of knowledge and attitude towards FW and in the amount of FW generated during the mid-morning break and lunch at schools. This study was conducted at a public Primary School in Valencia (Spain). Subtle changes in the level of knowledge and attitude towards FW were detected in teachers and pupils after the intervention. Around 30% of FW …
Review on the aging mechanisms in Li-ion batteries for electric vehicles based on the FMEA method
2014
With the increasing number of sold electric vehicles, the diagnosis of lithium ion traction batteries will become an important topic. For the development of diagnostic concepts, it is of high importance to have a good overview and knowledge of the internal aging mechanisms which happen inside a single cell. This paper presents a review of existing literature on this topic and summarizes the known aging mechanisms using the FMEA method (Failure Mode and Effects Analysis) in order to categorize them and establish the relationship between failure effects and causes. Based on the summarized information, new diagnostic concepts can be developed.
A Quality Risk Management Model Approach for Cell Therapy Manufacturing
2010
International regulatory authorities view risk management as an essential production need for the development of innovative, somatic cell-based therapies in regenerative medicine. The available risk management guidelines, however, provide little guidance on specific risk analysis approaches and procedures applicable in clinical cell therapy manufacturing. This raises a number of problems. Cell manufacturing is a poorly automated process, prone to operator-introduced variations, and affected by heterogeneity of the processed organs/tissues and lot-dependent variability of reagent (e.g., collagenase) efficiency. In this study, the principal challenges faced in a cell-based product manufacturi…
Assessing supply chain risks in the automotive industry through a modified MCDM-based FMECA
2020
Supply chains are complex networks that receive assiduous attention in the literature. Like any complex network, a supply chain is subject to a wide variety of risks that can result in significant economic losses and negative impacts in terms of image and prestige for companies. In circumstances of aggressive competition among companies, effective management of supply chain risks (SCRs) is crucial, and is currently a very active field of research. Failure Mode, Effects and Criticality Analysis (FMECA) has been recently extended to SCR identification and prioritization, aiming at reducing potential losses caused by lack of risk control. This article has a twofold objective. First, SCR assess…