Search results for "Effects"
showing 10 items of 2634 documents
Discrete Derivatives for Atom-Pairs as a Novel Graph-Theoretical Invariant for Generating New Molecular Descriptors: Orthogonality, Interpretation an…
2013
This report presents a new mathematical method based on the concept of the derivative of a molecular graph (G) with respect to a given event (S) to codify chemical structure information. The derivate over each pair of atoms in the molecule is defined as ∂G/∂S(vi , vj )=(fi -2fij +fj )/fij , where fi (or fj ) and fij are the individual frequency of atom i (or j) and the reciprocal frequency of the atoms i and j, respectively. These frequencies characterize the participation intensity of atom pairs in S. Here, the event space is composed of molecular sub-graphs which participate in the formation of the G skeleton that could be complete (representing all possible connected sub-graphs) or comp…
Symmetric BEM Formulations for Elastic-Damage Material Models
1997
BEM analysis for elastic-damage materials is addressed by “undamaged” fundamental solutions. In step-by-step analysis, the actual response is obtained by an iterative procedure in which the undamaged structure is subjected to the loads and to some fictitious strains (or relaxation stresses) simulating the damage effects. Through symmetric BEM, the solution to the typical iteration problem is shown to solve a boundary/domain stationarity principle, whereas the above iterative procedure can be incorporated in a predictor/corrector scheme aimed at the integration of the damage laws. Discretization by boundary and interior elements leads to a symmetric equation system.
Personal Goals of Older Female Twins
2009
This study examined genetic and environmental influences on older women’s personal goals by using data from the Finnish Twin Study on Aging. The interview for the personal goals was completed by 67 monozygotic (MZ) pairs and 75 dizygotic (DZ) pairs. The tetrachoric correlations for personal goals related to health and functioning, close relationships, and independent living were higher in MZ than DZ twins, indicating possible genetic influence. The pattern of tetrachoric correlations for personal goals related to cultural activities, care of others, and physical exercise indicated environmental influence. For goals concerning health and functioning, independent living, and close relationsh…
Exploring Neighborhood Influences on Small-Area Variations in Intimate Partner Violence Risk: A Bayesian Random-Effects Modeling Approach
2014
This paper uses spatial data of cases of intimate partner violence against women (IPVAW) to examine neighborhood-level influences on small-area variations in IPVAW risk in a police district of the city of Valencia (Spain). To analyze area variations in IPVAW risk and its association with neighborhood-level explanatory variables we use a Bayesian spatial random-effects modeling approach, as well as disease mapping methods to represent risk probabilities in each area. Analyses show that IPVAW cases are more likely in areas of high immigrant concentration, high public disorder and crime, and high physical disorder. Results also show a spatial component indicating remaining variability attribut…
Bērnības vardarbības ģimenē psiholoģiskā un psihiatriskā ietekme uz jauniešiem, kuri mācās universitātes līmenī
2022
Nosaukums: Bērnības vardarbības ģimenē psiholoģiskā un psihiatriskā ietekme uz jauniešiem, kuri mācās universitātes līmenī Authore: Katharina Franziska Melz, BA Darba vadītāja: Andis Užāns, MD Priekšvēsture: Vardarbība ģimenē jau sen ir atzīta par kaitīgu gan bērniem, gan pieaugušajiem. Daudzas valstis ir ieviesušas aizsardzības pasākumus, piemēram, nodrošinājušas audžuģimenes bērniem, kurus skārusi vardarbība ģimenē. Taču, tā kā vardarbība ģimenē parasti notiek tikai “aiz slēgtām durvīm”, ir jāpieņem, ka tā ir daudz izplatītāka, nekā liecina valsts statistika. Turklāt vardarbības ģimenē definīcija atšķiras, un to bieži uzskata par neērtu vai nepiemērotu diskusijai. Abi šie faktori apgrūtin…
Impact of Noah-LSM Parameterizations on WRF Mesoscale Simulations: Case Study of Prevailing Summer Atmospheric Conditions over a Typical Semi-Arid Re…
2021
The current study evaluates the ability of the Weather Research and Forecasting Model (WRF) to forecast surface energy fluxes over a region in Eastern Spain. Focusing on the sensitivity of the model to Land Surface Model (LSM) parameterizations, we compare the simulations provided by the original Noah LSM and the Noah LSM with multiple physics options (Noah-MP). Furthermore, we assess the WRF sensitivity to different Noah-MP physics schemes, namely the calculation of canopy stomatal resistance (OPT_CRS), the soil moisture factor for stomatal resistance (OPT_BTR), and the surface layer drag coefficient (OPT_SFC). It has been found that these physics options strongly affect the energy partiti…
Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.
2017
Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and e…
A prospective study of adverse drug reactions as a cause of admission to a paediatric hospital
1996
1A total of 512 consecutive paediatric hospital admissions of children 2 years old or less were evaluated to assess the extent and pattern of admission caused by suspected adverse drug reactions (ADRs). The proportion of suspected ADRs related to hospital admissions was 4.3%. 2The organ-systems most commonly implicated were the central nervous system (40.5%), digestive system (16.7%), and skin and appendages (14.3%). Together, they accounted for 71.5% of admissions attributed to ADRs. The most common clinical manifestations inducing admission were convulsions (4 cases), dizziness (4), vomiting (3), and tremor, fever, itching and apnoea (2 cases each). 3The four classes of drugs most frequen…
Immunotoxicity of Therapeutic Antibodies and Nanoparticles.
2020
Therapeutic antibodies and nanotherapeutic drugs are of great concern due to their widespread use against numerous diseases worldwide. They are frequently used for targeted therapy under the assumption that they cause fewer side effects than nontargeted drugs. Despite their specificity and particular design for therapeutic actions, they might still exhibit unintended adverse effects in the immune system. Immunotoxicity reactions are mediated by immunomodulation, including immunostimulation and immunosuppression. The present review gives an overview on the adverse immunotoxic effects induced by therapeutic antibodies as well as nanotherapeutic drugs. In this context, future methods combining…
Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
2007
The pharmaceutical industry is committed to marketing safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug-drug interactions. Drug metabolism is a major determinant of drug clearance and interindividual pharmacokinetic differences, and an indirect determinant of the clinical efficacy and toxicity of drugs. Progressive advances in the knowledge of metabolic routes and enzymes responsible for drug biotransformation have contributed to understanding the great metabolic variations existing in human beings. Phenotypic as well genotypic differences in the expression of the enzymes involved in drug metabolism are the main causes of this variability. How…