Search results for "Effects"
showing 10 items of 2634 documents
The Sea Urchin sns5 Chromatin Insulator Improves the Likelihood of Lentiviral Vectors in Erythroid Milieu By Organizing an Independent Chromatin Doma…
2015
Abstract Retroviral vectors are currently the most suitable vehicles for therapeutic gene transfer in hematopoietic stem cells. However, these vectors are known to integrate rather randomly throughout the genome, suffering the so called chromosomal position effects (PE). Such a critical occurrence most probably depends upon the ability of heterochromatin to spread in the inserted vector sequences. Moreover, the use of transgenes imply genotoxicity effects, since the cis-regulatory sequences harbored by the vector can disturb the proper transcription of the resident genes neighboring the integration site, potentially leading to malignant transformation. Due to their enhancer blocker activity…
Confort climático, cambio climático y actividad turística en Alicante
2016
Ponencia presentada en: X Congreso de la Asociación Española de Climatología celebrado en Alicante entre el 5 y el 8 de octubre de 2016. [ES]Los rasgos climáticos son esenciales para comprender la vocación turística de los territorios. En el litoral mediterráneo desde los años sesenta del siglo XX hay una especialización en el producto turístico basado en los rasgos climáticos de verano (sol y playa). La provincia de Alicante es un destino turístico principal en el área mediterránea española y esta actividad representa el 18% de su PIB provincial. Las condiciones climáticas actuales proporcionan valores de confort climático, según el índice TCI, muy buenos o excelentes durante la temporada …
Effect of Local Geology on Ground Motion in the City of Palermo, Italy, as Inferred from Aftershocks of the 6 September 2002 Mw 5.9 Earthquake
2005
On 6 September 2002 a M w 5.9 earthquake occurred in the southern Tyrrhenian sea, 40 km off the coast of Palermo (Italy). In the days after the mainshock, eight temporary stations were installed in the city to record aftershocks on different geological formations. Seismograms of about 30 earthquakes with magnitude ≥2.8 are analyzed. The data analysis confirms the role of near-surface geology in causing locally significant variations of the ground-shaking level as already inferred by Guidoboni et al. (2003) from historical damage scenario studies. The largest spectral variations estimated through aftershock recordings result in a factor of 10 difference between stiff and soft sites, in frequ…
Conceptualizing Core Aspects on Circular Economy in Cities
2021
Currently, there are many different interpretations in the literature of what a circular economy is and how it functions. As cities are still facing challenges to become fully sustainable, the need for a comprehensive analysis of how the circular economy can be implemented in urban areas is increasing. This article aims at outlining circular cities by their key characteristics and to further explore and provide a framework for fostering circularity at the city level. In order to achieve this goal, we performed a systematic review and analyzed key papers published in the field of circular economy to determine how circular economy practices form circular cities. We discovered that cities play…
Sustainable Infrastructure Projects: Systemic versus Traditional Delivery Models
2021
Sustainability involves multiple environmental, technical, social and economic factors, and such complex analysis requires systemic solutions. Delivery models are key to achieving system benefits and enhancing sustainable development in infrastructure investments. They define the phases of a project, incentive structures, risk sharing and the relationships among the actors in it. They are usually developed early in the project and determine the project dynamics and outcomes. We compared traditional delivery models with systemic ones. We identified and illustrated elements that differ between them through two cases. The contribution is an increased understanding of how systemic infrastructur…
Ecosystem Services at the Archipelago Sea Biosphere Reserve in Finland: A Visitor Perspective
2019
The United Nations Educational, Scientific and Cultural Organization&rsquo
Development of environmental health competencies through compulsory education. A polyhedral approach based on the SDGs
2020
This paper focuses on the competencies in environmental health acquired by students during compulsory education. Questionnaires addressing environmental health problems were completed by 923 students of primary and secondary schools from five different Spanish regions. The results for five challenging situations related to hunger, consumerism, climate change, pollution in the cities and allergies are analysed according to the internal coherence of each sub-competency, i.e., addressing knowledge, skills and attitudes towards these topics. Our results show that problems related to air and water pollution were the most commonly described by the students. Focusing on competency achievement, the…
German Marathon Runners' Opinions on and Willingness to Pay for Environmental Sustainability
2021
Research on sustainability and/in sport and, specifically, on the ecological aspects of participatory sporting events is still very scarce despite the recognition these topics have received by actors like, for instance, the European Commission and the United Nations. Against this backdrop, this paper sheds light on a field that is virtually uncharted in academic research, which is the environmental attitudes and willingness to pay for environmental sustainability of participants in participatory sporting events in Europe. In collaboration with the organizer of the Frankfurt Marathon, a study was conducted with a specific focus on German (speaking) marathon runners. In total 1764 data sets w…
Model to Assess the Quality of Magmatic Rocks for Reliable and Sustainable Constructions
2017
Geomechanical assessment of rocks requires knowledge of phenomena that occur under the influence of internal and external factors at a macroscopic or microscopic scale, when rocks are submitted to different actions. To elucidate the quantitative and qualitative geomechanical behavior of rocks, knowing their geological and physical–mechanical characteristics becomes an imperative. Mineralogical, petrographical and chemical analyses provided an opportunity to identify 15 types of igneous rocks (gabbro, diabases, granites, diorites, rhyolites, andesites, and basalts), divided into plutonic and volcanic rocks. In turn, these have been grouped into acidic, neutral (intermediate) and basic magmat…
Measuring Sustainability with Unweighted TOPSIS: An Application to Sustainable Tourism in Spain
2021
The measurement of sustainability is complex due to its multiple dimensions of different relative importance and different natures. From the perspective of sustainability, three types of tourism can be established: traditional tourism, sustainable tourism, and sustainable impact tourism. In the context of multiple-criteria decision analysis, this paper presents a flexible method for assess and rank decision alternatives based on their sustainability. The proposal does not require the relative importance of each criterion to be precisely assigned beforehand, which reduces the subjectivity of the decision making and yields results that can be of interest for decision makers. To show the diffe…