Search results for "Eje"

Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies

2019

Abstract: Kidney transplantation is considered the favored treatment for patients suffering from end-stage renal disease, since successful transplantation is associated with longer survival and improved quality of life compared to dialysis. Alloreactive immune responses against the donor kidney may lead to acute rejection of the transplant. The current diagnosis of renal allograft rejection mainly relies on clinical monitoring, including serum creatinine, proteinuria, and confirmation by histopathologic assessment in the kidney transplant biopsy. These parameters have their limitations. Identification and validation of biomarkers, which correlate with or predict the presence of acute reject…

Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat …

2019

Moderate exercise training may not be sufficient to exert beneficial effects on the cardiovascular system because of the long-term multifactorial etiology of diabetic complications. The addition of a proper pharmacological tool to the physical exercise should improve the outcomes of the diabetic damage. Here it is shown that 8 weeks exercise training of type 1 diabetic Sprague-Dawley (SD) rats resulted in a significantly increased heart rate, a 14% increase in the left ventricular ejection fraction (LVEF) increased plasma insulin levels and a 13% decrease in plasma glucose with respect to sedentary animals. The training also resulted in a 22% reduction in cardiac QT interval from a diabetic…

Hábitos saludables en universitarios de ciencias de la salud y de otras ramas de conocimiento: un estudio comparativo

2019

Introducción: Durante la vida universitaria, los estudiantes deberían consolidar sus hábitos saludables, que se verán reflejados posteriormente en su vida adulta. Esto es de especial importancia en el caso de los estudiantes que lleguen a ser profesionales del ámbito de la salud. Sin embargo, gran parte de la literatura concluye que los estudiantes reportan malos hábitos durante el periodo universitario. Objetivos: El presente estudio pretende determinar si estudiantes de ciencias de la salud (ECS) y estudiantes de otras ciencias (EOC) presentan hábitos saludables relacionados con la práctica de actividad física (AF) y adherencia a la Dieta Mediterránea (DM). Asimismo, saber si los ECS tien…

Estudio de los hábitos alimentarios, actividad física, nivel socioeconómico y sedentarismo en adolescentes de la ciudad de Valencia

2020

Introducción: Unos adecuados hábitos alimenticios, junto a la práctica regular de actividad física son importantes para adoptar un estilo de vida saludable. En la actualidad, existe un abandono generalizado de la actividad física y la adopción de comportamientos sedentarios durante la adolescencia, así como la pérdida de unos óptimos patrones alimenticios. Material y métodos: El presente estudio tiene como objetivo conocer los hábitos alimenticios de 170 adolescentes de la ciudad de Valencia y saber si este comportamiento nutricional guarda relación con variables como la actividad física, el nivel socioeconómico, el tiempo de actividad sedentaria o el perfil de peso. Resultados: El análisis…

Efficacy and Safety of Zofenopril Versus Ramipril in the Treatment of Myocardial Infarction and Heart Failure: A Review of the Published and Unpublis…

2018

Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA). Zofenopril demonstrated its superiority over ramipril in reducing…

Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes

2019

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Step by Step Toward Biomarker-Based Precision Medicine in Heart Failure

2019

> You wouldn't wear just any pair of glasses—your prescription is tailored to your vision. This statement was made by President Obama in 2016 during the presentation and launch of the Precision Medicine Initiative. Whether we like it or not (and some politicians today seem rather indifferent), we are headed toward a new paradigm of precision medicine. This is a new era of medicine in which the right treatment is delivered at the right time to the right person. In the context of heart failure (HF)5 there is a long road ahead to fully realize the goals of precision medicine. HF is a complex syndrome with heterogeneous pathophysiology. Most medical treatments currently used in HF have been tes…

INFORMACIÓN Y EXPOSICIÓN INDIRECTA PARA REDUCIR ESTEREOTIPOS HACIA EL ENVEJECIMIENTO

2016

Abstract.Purpose: The Image that society has about older people has been built on a base of stereotypes, far away from reality. This social image will have a determinant influence on attitudes and behaviors from all those people related with them, including health care professionals. It should be mandatory to eradicate negative stereotypes against aging during university formation, and in this practice get sensitive professionals who will attend people in their final state of life. Method: the treatment “Information plus indirect experience” was set throw the viewing of the short film “Como un Rolling” (Castilla, 2013). This film exposes the concept of active aging, and had the purpose to b…

2015

Background Atrial fibrillation (AF), whether silent or symptomatic, is a frequent and severe complication of acute myocardial infarction (AMI). Asymmetric dimethylarginine (ADMA), an endogenous eNOS inhibitor, is a risk factor for endothelial dysfunction. We addressed the relationship between ADMA plasma levels and AF occurrence in AMI. Methods 273 patients hospitalized for AMI were included. Continuous electrocardiographic monitoring (CEM) ≥48 hours was recorded and ADMA was measured by High Performance Liquid Chromatography on admission blood sample. Results The incidence of silent and symptomatic AF was 39(14%) and 29 (11%), respectively. AF patients were markedly older than patients wit…

PERCEPCIONES DE LOS DÉFICITS DE FUNCIONAMIENTO EJECUTIVO DE ADULTOS CON TDAH VERSUS PERCEPCIONES DE SUS FAMILIARES

2015

Introducción. Los niños con TDAH tienden a sobreestimar su funcionamiento social, conductual y académico, un asunto que ha sido poco investigado en adultos con TDAH. Objetivos. Los objetivos de este trabajo son: 1) Examinar el perfil de funcionamiento ejecutivo de adultos jóvenes con TDAH; 2) Estudiar la relación entre las habilidades de funcionamiento ejecutivo percibidas por adultos con TDAH y sus padres; 3) Comparar las puntuaciones diferenciales (entre las versiones de observador y autoinforme) de adultos con TDAH y adultos con desarrollo típico. Método. Participaron 93 adultos (50 con un diagnóstico de TDAH en la infancia y 43 con desarrollo típico) entre 17 y 24 años. Se aplicaron las…