Search results for "Emt"
showing 10 items of 413 documents
Follow Up On CD8-Depleted Donor-Lymphocyte Infusions After T-Cell Depleted Allogeneic Hemopoietic Stem Cell Transplantation
2013
We applied prophylactic CD8-depleted (CD8depl) donor lymphocyte infusions (DLI) in the setting of T-cell depleted reduced-intensity allogeneic hematopoietic stem cell transplantation (HSCT) in a phase I/II trial. T-cell depletion was carried out by the use of high-dose Alemtuzumab (100 mg or 60 mg for unrelated or sibling donor transplantation, respectively). We have demonstrated the feasibility of this approach after having treated 23 patients in this protocol (Meyer et al. Blood 2007). From 2004 to 2011, 134 patients with different hematologic diseases were included and followed for a median observation time of 1.5 years after transplantation (range, 1.5-9 years). Median age was 56 years …
Prior Treatment with Alemtuzumab Interferes with T-Cell Engraftment After Allogeneic Stem Cell Transplantation in Patients with Chronic Lymphocytic L…
2009
Abstract Abstract 3351 Poster Board III-239 Objectives: The majority of patients with chronic lymphocytic leukemia (CLL) who receive allogeneic hematopoietic cell transplantation (HCT) have fludarabine-refractory disease. The most active single agent in this disease stage is alemtuzumab. Alemtuzumab has a long half-life and induces profound T-cell depletion (TCD). Since TCD may mitigate graft-versus leukemia effects we evaluated „pre-conditioning“ with alemtuzumab followed by a washout period in order to minimize in vivo T-cell depletion of the graft in a phase II study (NCT 00337519). Methods: Patients received cytoreductive treatment with 3 × 30 mg alemtuzumab weekly prior to HCT. The sch…
Changes in Pupil Area during Low-energy Femtosecond Laser-assisted Cataract Surgery
2018
Purpose: To study the potential changes in pupil area within low-energy femtosecond-laser assisted cataract surgery (FLACS). Methods: A retrospective assessment of the pupil size was performed in the eyes undergoing FLACS using the Ziemer LDV Z8. We measured the pupil diameters as part of the images taken preoperatively and at the completion of laser pretreatment (after releasing the suction). We calculated the pupil area in 40 eyes of 40 patients (14 right and 26 left eyes). The mean ± standard deviation (SD) of age of the patients was 74 ± 7.4 years (range: 51-87). Paired t-test was used for statistical analyses. Subgroups were built with reference to age and preoperative pupil area (smal…
Estudio del papel de la EMT y las vías de control inmunológico en las micrometástasis moleculares detectadas en ganglio centinela de pacientes con ca…
2021
En los últimos años se ha incrementado el uso de técnicas de biología molecular para mejorar el diagnóstico y conocer mejor la etiología del CP (cáncer pulmonar), debido a que la posibilidad de padecerlo ha sido definida como la interrelación entre la exposición a carcinógenos ambientales y la susceptibilidad individual determinada genéticamente (D’Amico et al., 1999). Dicha susceptibilidad genética es la que resulta determinante para entender por qué, siendo el tabaco responsable de más del 90% de los CP en el hombre y del 80% en la mujer, sólo un 11-12% de los fumadores desarrollan un cáncer (Kratz et al., 2012). Sin embargo, comprender qué factores genéticos determinan una mayor propensi…
Trastuzumab-emtansine induced pleural and pericardial effusions
2021
Introduction Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate which combine trastuzumab (T), a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), and a cytotoxic molecule derived from maytansine (DM1). Case report We report the first case of T-DM1-associated pleural and pericardial effusions three weeks after the second course of T-DM1 in a patient with breast cancer. Drug-induced pleural and pericardial effusions was implicated in the absence of other etiologies. The Naranjo Scale indicated a probable drug-induced adverse reaction. Management & outcome: The patient fully recovered after thoracentesis and discontinuation of T-DM1. The patient h…
Negative and positive Kerr nonlinearity of air calibrated with transient molecular alignment
2009
Talk given by O. Faucher; International audience; Nonlinear electronic Kerr index of the major air constituents has been measured up to high order terms using transient molecular alignment as a reference. Sign reversal associated to negative nonlinearity is observed above a pulse intensity of 26 TW/cm^.2
Unravelling the Intertwined Atomic and Bulk Nature of Localised Excitons by Attosecond Spectroscopy
2021
The electro-optical properties of most semiconductors and insulators of technological interest are dominated by the presence of electron-hole quasi-particles, called excitons. The manipulation of excitons in dielectrics has recently received great attention, with possible applications in different fields including optoelectronics and photonics. Here, we apply attosecond transient reflection spectroscopy in a sequential two-foci geometry and observe sub-femtosecond dynamics of a core-level exciton in bulk MgF2 single crystals. Furthermore, we access absolute phase delays, which allow for an unambiguous comparison with theoretical calculations. Our results show that excitons surprisingly exhi…
Pienācīgā kārtībā pieņemta likuma saturs cilvēka pamattiesību ierobežošanas kontekstā
2019
Darbā tiek pētīts pienācīgā kārtībā pieņemta likuma saturs cilvēka pamattiesību ierobežošanas kontekstā. Lai pilnvērtīgāk izpētītu šo jautājumu, darba ietvaros tiek pētīta ne tikai Latvijas tiesu prakse, bet arī Eiropas Cilvēktiesību tiesas prakse un tās ietekme uz Latvijas pamattiesību ierobežošanas metodoloģiju. Pētījumu rezultātā autore secina, ka Satversmes tiesa, veidojot nacionālo pamattiesību ierobežošanas mehānismu, lielā mērā ir iedvesmojusies no Eiropas Cilvēktiesību tiesas judikatūras, kā arī šobrīd Satversmes tiesa turpina veidot savu tiesu praksi atbilstoši jaunākām Eiropas Cilvēktiesību tiesas atziņām. Izpētot Satversmes tiesas praksi, autore secina, ka Latvijā pamattiesību ie…
Grid-Following and Grid-Forming MODELS in ATP-EMTP for Power Systems Simulation
2022
The paper presents the models of grid-following and grid-forming converters in the software ATP-EMTP for power systems simulation. The models are developed using the MODELS language, they are described in details discussing all issues and aspects related to the implementation, and they are also shared as open source models. The models are validated with a simulation-based approach, comparing the results with the models developed in MATLAB/Simulink and in NEPLAN, considering both the phasor RMS and EMT time domains, and thus performing a comprehensive cross-platform and cross-domain validation. In line with the spirit of the ATP software and community, the models of grid-following and grid-f…
One-dimensional pion, kaon, and proton femtoscopy in Pb-Pb collisions at √sNN = 2.76 TeV
2015
The size of the particle emission region in high-energy collisions can be deduced using the femtoscopic correlations of particle pairs at low relative momentum. Such correlations arise due to quantum statistics and Coulomb and strong final state interactions. In this paper, results are presented from femtoscopic analyses of π±π±, K±K±, K0 SK0 S, pp, and pp correlations from Pb-Pb collisions at √sNN = 2.76 TeV by the ALICE experiment at the LHC. One-dimensional radii of the system are extracted from correlation functions in terms of the invariant momentum difference of the pair. The comparison of the measured radii with the predictions from a hydrokinetic model is discussed. The pion and kao…