Search results for "Engineering sciences"
showing 10 items of 2347 documents
Immunotherapy for recurrent ovarian cancer: a further piece of the puzzle or a striking strategy?
2014
Introduction: Treatment of ovarian cancer has been long standardized with the inclusion of surgery and chemotherapy based on platinum and taxanes, this strategy reaching high remission rates. However, when this treatment fails, further options are available with little benefit. Since ovarian cancer has specific immunologic features, actually immunotherapy is under evalua- 15 tion to overcome treatment failure in patients experiencing recurrence. Areas covered: Immunogenicity of ovarian cancer and its relationship with clinical outcomes is briefly reviewed. The kinds of immunotherapeutic strategies are summarized. The clinical trials investigating immunotherapy in recurrent ovarian cancer pa…
On chip optical nanotweezing for dielectric particles manipulation
2014
On chips optical nanocavities have become useful tools for trapping and manipulation of colloidal objects. In this thesis we study the nanocavities as building blocks for optical forces, trapping and handling of particles. Proof of concept of trapping dielectric microspheres appears as the starting point of the development of lab on chip. In the first chapter we go through the literature of optical forces in free space and integrated optics. The second chapter presents the experimental tools for the characterization of nanocavities and the set-up developed to perform optical measurements with the colloidal particles. The third chapter describes the proof-of-concept trapping of polystyrene p…
Vulnerability of OFDR-based distributed sensors to high γ-ray doses
2015
Vulnerability of Optical Frequency Domain Reflectometry (OFDR) based sensors to high γ-ray doses (up to 10 MGy) is evaluated with a specific issue of a radiation-hardened temperature and strain monitoring system for nuclear industry. For this, we characterize the main radiation effects that are expected to degrade the sensor performances in such applicative domain: the radiation-induced attenuation (RIA), the possible evolution with the dose of the Rayleigh scattering phenomenon as well as its dependence on temperature and strain. This preliminary investigation is done after the irradiation and for five different optical fiber types covering the range from radiation-hardened fibers to highl…
Managing Group and Phase Birefringence for Nonlinear Optics in Photonic Crystal Fibers
2006
A novel design of birefringent photonic crystal fibers with stress applying parts permits to manage the wavelength dependence of group and phase birefringence. Applications to vector frequency conversion and soliton polarization instabilities are discussed.
An original method to compute epipoles using variable homography: application to measure emergent fibers on textile fabrics
2012
International audience; Fabric's smoothness is a key factor to determine the quality of finished textile products and has great influence on the functionality of industrial textiles and high-end textile products. With popularization of the 'zero defect' industrial concept, identifying and measuring defective material in the early stage of production is of great interest for the industry. In the current market, many systems are able to achieve automatic monitoring and control of fabric, paper, and nonwoven material during the entire production process, however online measurement of hairiness is still an open topic and highly desirable for industrial applications1. In this paper we propose a …
Demonstration of polarization pulling using a fiber-optic parametric amplifier
2012
International audience; We report the observation of all-optical polarization pulling of an initially polarization-scrambled signal using parametric amplification in a highly nonlinear optical fiber. Broadband polarization pulling has been achieved both for the signal and idler waves with up to 25 dB gain using the strong polarization sensitivity of parametric amplifiers. We further derive the probability distribution function for the final polarization state, assuming a randomly polarized initial state, and we show that it agrees well with the experiments.
Pulsed X‐Ray Radiation Responses of Solarization‐Resistant Optical Fibers
2018
International audience; The transient radiation‐induced attenuation (RIA) of two different versions of pure‐silica‐core (PSC) multimode optical fibers (so‐called “solarization‐resistant” fibers) exposed to nanosecond 1 MeV X‐ray pulses are investigated. On‐line RIA spectra measurements at both room temperature (RT) and liquid nitrogen temperatures (LNT) in the range 1–3.5 eV are performed. Following the RIA kinetics, the properties of the metastable defects that are bleached just after the pulse are discussed. The spectral decomposition of the RIA is performed using known Gaussian bands associated to point defects absorbing in this spectral range. For both fiber types, the generation and th…
Performance Analysis of a Prototype High‐Concentration Photovoltaic System Coupled to Silica Optical Fibers
2021
High-concentration photovoltaic (HCPV) systems are one of the most promising technologies for the generation of renewable energy with high-conversion efficiency. Their development is still at an early stage, but the possibility of integrating high-concentration systems into buildings offers new opportunities to achieve the net-zero-energy building goal. Herein, the optical and energetic performance of a hybrid daylighting−HCPV prototype based on pure- or doped-silica optical fibers (OFs) to guide 2000× concentrated sunlight inside the buildings is evaluated. There, the light can either be used to illuminate interior spaces or projected on solar cells to generate electricity. The system equi…
Demonstration of Stimulated-Raman-scattering suppression in optical fibers in a multifrequency pumping configuration
1999
International audience; We analyze the stimulated-Raman-scattering-(SRS) process induced by a linearly polarized multifrequency pump field in a normally dispersive single-mode fiber. We show, by theoretical analysis and numerical simulations, that the SRS process may be either controlled by switching all the generated Stokes radiations to the lowest-frequency pump or suppressed for all the frequency components of the pump field. The suppression process is achieved by an appropriate choice of the frequency separation between the pumps and a particular power distribution among the frequency components of the pump field. We present experimental spectra showing the effectiveness of this suppres…
Hydrogen and radiation induced effects on performances of Raman fiber-based temperature sensors
2014
International audience; Raman Distributed Temperature Sensors (RDTS) offer exceptional advantages for the monitoring of the envisioned French deep geological repository for nuclear wastes, called Cigéo. Here, we present experimental studies on how the performances of RDTS evolve in harsh environments like those associated with H2 or g-rays. Both of them are shown to strongly affect the temperature measurements made with RDTS. We showed that by adapting the characteristics of the used fiber for the sensing, we could limit its degradation but that additional hardening by system studies will have to be developed before integration of RDTS in Cigéo.