Search results for "Enhancement."
showing 7 items of 557 documents
Monografie di Agathòn. Atti del Symposium East-West Artistic and Technological Contaminations/Oriente-Occidente. Contaminazioni Artistiche e Tecnolog…
2013
AgAthón, the Ph.D.’s journal collecting together the best of the works about the renovation and the enhancement of ancient contexts, has had increasing success among institutions and both Italian and foreign researchers. The choral pattern chosen in the four sectors, which alludes to the Greek city, has certainly contributed to create this appreciation: the Agorá, like the central space in the pólis, for guest contributions; the Stoá, the covered portico under which the philosopher Zeno used to teach his disciples, for the Ph.D. teachers’ contributions; the gymnásion, the place of endeavour for young Greeks training their bodies and minds, is the section meant for the doctoral candidates; l…
Measurement of dielectron production in central Pb-Pb collisions at √sNN = 2.76 TeV
2019
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. The first measurement of dielectron (e + e −) production in central (0 – 10 %) Pb – Pb collisions at √sNN=2.76TeV at the LHC is presented. The dielectron invariant-mass spectrum is compared to the expected contributions from hadron decays in the invariant-mass range 0 < mee < 3.5 GeV / c2. The ratio of data and the cocktail of hadronic contributions without vacuum ρ0 is measured in the invariant-mass range 0.15 < mee < 0.7 GeV / c2, w…
The Nasal Epithelium as a Factory for Systemic Protein Delivery
2002
We have previously shown that recombinant Sendai virus (SeV) produces efficient in vivo airway epithelial gene transfer. The ability to produce therapeutic levels of circulating proteins following noninvasive gene transfer would have widespread clinical application. Here, we compared nose, lung, and skeletal muscle for the ability to produce circulating levels of the secreted mouse antiinflammatory cytokine interleukin-10 (IL10) following SeV-mediated gene transfer. High levels of serum IL10 were obtained from each site with a potency order of lung > nose > muscle for a given viral titer. Serum levels from each site were within the likely required range for anti-inflammatory effects. The co…
Genomic structure and promoter analysis of pathogen-inducedrepatgenes fromSpodoptera exigua
2009
The repat gene family encodes midgut proteins overexpressed in response to pathogen infection in the lepidopteran Spodoptera exigua. Up-regulation of repat genes has been observed after challenging the larvae with both Bacillus thuringiensis toxins and after infection with the baculovirus Autographa californica multiple nucleopolyhedrovirus. In our study, PCR amplification of the genomic region and genome walking were used to obtain the genomic structure and the sequence of the 5'-upstream region of repat1 and repat2, two of the most phylogenetically distant members of the repat family. A similar gene structure between repat1 and repat2 has been found, with conserved exon-intron positions a…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
Continuidad de las innovaciones tecnológicas: el reto de las intervenciones biomédicas de mejora humana
2013
One of the most recent debates among ethicists concerning the course of technological innovation is the human enhancement debate, which has been generated by the possibility of pushing human limits further by using the power of science. Many philosophers have warned us about the dangers of modifying human nature in a technical way. However, others argue that there are no morally salient differences between enhancing technical interventions and other kinds of technologies that human beings have taken to be usual for them. This paper shall critically analyze this argument. The main aim of this critical analysis is twofold, first, to show that people who make this argument are biased in severa…
Audzēkņu instrumentspēles prasmju un ķermeņa darbības pilnveides mijsakarības trombona spēles mācību procesā mūzikas skolā
2015
Trombona spēles pedagoģija bieži vien izmanto paņēmienus un metodes, kas ir pretrunā ar cilvēka ķermeņa darbības fizioloģiskajiem principiem un var gan kavēt un ierobežot instrumentspēles prasmju attīstību, gan radīt kaitējumus mūziķa veselībai. Ārvalstu mūzikas pedagoģijas zinātniskajā literatūrā arvien lielāks uzsvars tiek likts uz cilvēka darbības psiholoģisko un fizioloģisko mehānismu un likumsakarību integrēšanu pedagoģiskajā procesā. Arī trombona spēles prasmju pilnveidi nepieciešams balstīt cilvēka ķermeņa darbības pamatprincipos. Mērķis: izpētīt trombona spēles prasmju pilnveides teorētiskos aspektus un izstrādāt ķermeņa darbības psihofizioloģiskajos pamatprincipos balstītu vingrinā…