Search results for "Enos"

Epidemiology, clinical manifestations, risk-reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agen…

2014

Osteonecrosis of the jaws (ONJ) is an adverse side event of bisphosphonates and denosumab, antiresorptive agents that effectively reduce the incidence of skeletal-related events in patients with metastatic bone cancer and multiple myeloma. Available data suggest that 0–27.5% of individuals exposed to antiresorptive agents can develop ONJ. There is increasing evidence that avoidance of surgical trauma and infection to the jawbones can minimize the risk of ONJ, but there are still a significant number of individuals who develop ONJ in the absence of these risk factors. Bone necrosis is almost irreversible and there is no definitive cure for ONJ with the exclusion, in certain cases, of surgica…

Onset of MRONJ in Breast Cancer Patients after Switching from Low to High Dose of Bone Modifying Agents Due to Bone Metastases Development: A Single …

2022

Background: Medication-Related Osteonecrosis of the Jaw (MRONJ) is an adverse drug reaction mainly associated to bone modifying agents (BMAs). Breast cancer (BC) is the most frequent cancer worldwide. Its therapy can cause cancer treatment-induced bone loss (CTIBL), commonly treated with BMAs. The aims of this retrospective study are: to describe characteristics of BC patients under BMAs for CTIBL; to record any switch to high-dose BMAs; to assess MRONJ onset and to identify any factors associated with it. Patients: Authors included patients referred for MRONJ prevention to the Unit of Oral Medicine (University Hospital of Palermo). Results: Fourteen female BC patients under low-dose BMAs f…

Fluidos intravenosos isotónicos en el paciente pediátrico: evolución de la natremia y efectos adversos

2016

Los fluidos hipotónicos se siguen usando de forma mayoritaria en niños hospitalizados pese al riesgo de hiponatremia iatrogénica, edema cerebral y muerte reportado en la literatura científica y en las advertencias de seguridad de organismos sanitarios internacionales. Se sabe que estímulos frecuentes en los niños hospitalizados inducen secreción no osmótica de ADH . Si a estas circunstancias sumamos el empleo de fluidos hipotónicos como los que resultan del trabajo clásico de Holliday-Segar se genera un riesgo aumentado de hiponatremia de hasta el 30%. El riesgo principal de la hiponatremia iatrogénica es la encefalopatía hiponatremica que lleva a la muerte en el 10% de los casos y a una in…

Relevancia clínica de la sensibilización a polen de morera y estudio de su reactividad cruzada con otros pólenes

2016

Introducción: debido a la presencia de Morus alba en los captadores de polen del área de Valencia, así como la falta de estudios de sensibilización y relevancia clínica con dicho polen, la alergia a este polen podría estar infradiagnosticada. Además, es posible que exista reactividad cruzada con otros pólenes del área de estudio ya que actualmente únicamente hay dos proteínas descritas en polen de Morus alba y ambas son panalérgenos, alérgenos con homología estructural en su secuencia de aminoácicos y que pertenecen a distintas fuentes alergénicas. Se plantea la hipótesis de que el polen de morera está implicado en la sintomatología de los pacientes alérgicos a pólenes, además de presentar …

Estudio biomecánico y correlación clínica de los sistemas de artrodesis cervical anterior caja-placa

2021

Nº Tesis 12712 dentro del Programa de Medicina del Departamento de Cirugía de la Facultad de Medicina y Odontología de la Universidad de Valencia Tutor: Guillermo García-March. Fecha de lectura: 24 de septiembre de 2021. Calificación. Sobresaliente cum laude.

Mid-term and late results of endovascular treatment for symptomatic carotid artery stenosis under proximal protection

2021

Introduction: Although filters are still preferred during carotid stenting, proximal protection systems (PPS) are increasingly used during these procedures. PPS seem to be safer than distal systems, especially in symptomatic patients, but evidence supporting their use is limited. Aim: This was a post hoc survey with 30-day mid-term and long-term follow up, which was aimed at assessment of the safety and efficacy of stenting of the internal carotid artery under PPS in symptomatic patients. Material and methods: We analysed the results of stenting in 120 symptomatic patients presenting with at least 60% stenosis. Patients were aged 67.9 ±9.8 years, and 12 patients were older than 80 years. An…

Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cell

2017

A new naphthol-based rhodamine derivative (NpRD) has been developed for the selective and differential detection of adenosine 3′,5′-cyclic monophosphate (cAMP) and adenosine phosphates (APs) (ATP, ADP, and AMP) from other nucleotides. The simple detection and quantification of cAMP in human blood cells and in other samples based on the ‘turn on’ fluorescence properties of this chemosensor through colorimetry or fluorometry makes it unique for probable application in high throughput screening. peerReviewed

Dexamethasone Dipropionate Loaded Nanoparticles Of -Elastin-G-Plga For Potential Treatment Of Restenosis

2013

Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…

1994

Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…

Rho GTPases are over-expressed in human tumors.

1999

Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…