Search results for "Entacapone"
showing 5 items of 5 documents
Inhibition of Peripheral Dopamine Metabolism and the Ventilatory Response to Hypoxia in the Rat
2014
Dopamine (DA) is a putative neurotransmitter in the carotid body engaged in the generation of the hypoxic ventilatory response (HVR). However, the action of endogenous DA is unsettled. This study seeks to determine the ventilatory effects of increased availability of endogenous DA caused by inhibition of DA enzymatic breakdown. The peripheral inhibitor of MAO – debrisoquine, or COMT – entacapone, or both combined were injected to conscious rats. Ventilation and its responses to acute 8 % O2 in N2 were investigated in a whole body plethysmograph. We found that inhibition of MAO augmented the hyperventilatory response to hypoxia. Inhibition of COMT failed to influence the hypoxic response. Ho…
Structural studies of acyl esters of entacapone
2001
Abstract The crystal structures of entacapone [(E)-2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide] and three of its acyl esters were solved. Entacapone, and its monopivaloate and diacetate derivatives, exist in the E-form while its dibenzoate derivative adopts the Z-form in the crystalline state. The ethyl substituents of the E-form are not freely rotating, as demonstrated by the broad signals in the 1H and 13C NMR spectra. The rotation barrier for the E-form was defined by the crystal structures, which show that free rotation of the ethyl substituents is blocked by the cyano-group.
CCDC 149907: Experimental Crystal Structure Determination
2002
Related Article: J.Leppanen, E.Wegelius, T.Nevalainen, T.Jarvinen, J.Gynther, J.Huuskonen|2001|J.Mol.Struct.|562|129|doi:10.1016/S0022-2860(00)00859-0
CCDC 149909: Experimental Crystal Structure Determination
2002
Related Article: J.Leppanen, E.Wegelius, T.Nevalainen, T.Jarvinen, J.Gynther, J.Huuskonen|2001|J.Mol.Struct.|562|129|doi:10.1016/S0022-2860(00)00859-0
CCDC 149908: Experimental Crystal Structure Determination
2002
Related Article: J.Leppanen, E.Wegelius, T.Nevalainen, T.Jarvinen, J.Gynther, J.Huuskonen|2001|J.Mol.Struct.|562|129|doi:10.1016/S0022-2860(00)00859-0