Search results for "Entera"
showing 10 items of 186 documents
The first colonization of Ibiza and Formentera (Balearic Islands, Spain): Some more islands out of the stream?
1995
Abstract The Balearic Islands, off the east coast of Spain, have provided a focus of interest in investigations of the earliest colonization of the Mediterranean islands, because of the relatively late date of their oldest sites. Mallorca was visited in the fifth millennium BC and inhabited by the third, and Menorca was colonized during the closing centuries of the third millennium; this therefore makes Ibiza and Formentera special cases of isolation, since they were evidently not occupied until about 2000 BC and moreover were essentially deserted between roughly the thirteenth and seventh centuries BC. The paper presents all the currently available data relevant to this question, particula…
La prehistoria de Ibiza y Formentera: estado actual de la investigación
1988
The study of the prehistory of Ibiza and Formentera, the two small islands that form the Pityussae sub-group within the Balearic archipelago, began a few years ago as a consequence of the discovery and excavation of the megalithic chamber tomb of a Ca Na Costa on Formentera. Before then, prehistorians were still in doubt as to whether these islands had been occupied before the Phoenician colonisation. Many sites have come to light in the last decade, allowing us to present for the first time a general survey of the prehistoric settlement of the islands. Nevertheless, many problems are still unsolved, and new excavations are needed to establish the apparently complex cultural sequence, which…
The taxonomy of Galium crespianum J.J. Rodr. (Rubiaceae), a Balearic Islands endemic revisited
2001
Abstract Galium crespianum J.J. Rodr. is a perennial plant inhabiting cliffs and crevices on the Balearic Islands. Although it was described from the mountains of Mallorca, several populations from the islands of Eivissa and Formentera have been traditionally considered as belonging to the same species. A careful comparison of specimens from the western and eastern Balearics revealed several discriminant features in gross morphology (robustness and habit of the stems, presence or absence of hairs at the internodes and leaves, waxiness of stems and leaves, shape of the inflorescence, flower colour and scent) and stem anatomy. In addition, several mutations in the ribosomal ITS sequences dist…
Indocyanine Green to Assess Vascularity of Ileal Conduit Anastomosis During Pelvic Exenteration for Recurrent/Persistent Gynecological Cancer: A Pilo…
2021
IntroductionPelvic exenteration performed for recurrent/persistent gynecological malignancies has been associated with urological short- and long-term morbidity due to altered vascularization of tissues for previous radiotherapy. The aims of the present study were to describe the use of intravenous indocyanine green (ICG) to assess vascularity of urinary diversion (UD) after pelvic exenteration for gynecologic cancers, to evaluate the feasibility and safety of this technique, and to assess the postoperative complications.MethodsProspective, observational, single-center, pilot study including consecutive patients undergoing anterior or total pelvic exenteration due to persistent/recurrent gy…
The burden of Candida species colonization in NICU patients: a colonization surveillance study
2017
Fungal infections are an important cause of morbidity and mortality in neonatal intensive care units (NICUs). The identifi-cation of specific risk factors supports pre-vention of candidemia in neonates. Effec-tive prophylactic strategies have recently become available, but the identification and adequate management of high-risk in-fants is still a priority. Prior colonization is a key risk factor for candidemia. For this reason, surveillance studies to monitor in-cidence, species distribution, and antifun-gal susceptibility profiles, are mandatory. Among 520 infants admitted to our NICU between January 2013 and December 2014, 472 (90.77%) were included in the study. Forty-eight out of 472 (…
CE characterization of potential toxic labile iron in colloidal parenteral iron formulations using off-capillary and on-capillary complexation with E…
2007
The present study describes the application of CZE to investigate the portion of labile iron in the following parenteral formulations: iron gluconate, iron saccharate, and iron dextran. Labile iron was detected as Fe(III)-chelate of EDTA at 246 nm. When EDTA was incubated with the formulations before electrophoresis, labile iron, or chelatable iron, respectively, was detected in all formulations, mostly in iron gluconate and iron saccharate. It was observed that the amount of iron released is time- and pH-dependent. In contrast, when EDTA was separately injected before the formulation sharp peaks of the Fe(III)-chelate were detected only after injection of iron gluconate. This type of labil…
336 Is a vaginectomy enough or is a pelvic exenteration always required for surgical treatment of recurrent cervical cancer?
2020
Introduction No consensus has yet been reached on the best strategy for treatment of cervical cancer local recurrence. Vaginectomy could be a salvage treatment in selected patients. Methods The records of vaginal recurrent cervical cancer patients admitted at Fondazione Policlinico ‘Agostino Gemelli’ IRCCS in Rome from January 2010 to June 2019 were retrospectively analyzed. We reported perioperative and survival outcomes of vaginectomy with respect to a matched series of pelvic exenteration (PE). Results Fifteen women underwent vaginectomy and 30 patients were submitted to PE. No statistical differences were observed between the two groups at baseline characteristics. The vaginectomy proce…
Structural characterization of iron oxide/hydroxide nanoparticles in nine different parenteral drugs for the treatment of iron deficiency anaemia by …
2013
Drug products containing iron oxide and hydroxide nanoparticles (INPs) are important for the treatment of iron deficiency anaemia. Pharmaceuticals prepared by the complexation of different kinds of INPs and carbohydrates have different physicochemical and biopharmaceutic characteristics. The increasing number of parenteral non-biological complex drugs (NBCD) containing iron requires physicochemical methods for characterization and enabling of cross comparisons. In this context the structure and the level of crystallinity of the iron phases may be connected to the in vitro and in vivo dissolution rates, which etiologically determine the therapeutic and toxic effects. X-ray powder diffraction…
Physicochemical stability of carfilzomib (Kyprolis®) containing solutions in glass vials, ready-to-administer plastic syringes and infusion bags over…
2017
Centralized aseptic preparation of ready-to-administer carfilzomib containing parenteral solutions in plastic syringes and polyolefine (PO) infusion bags needs profound knowledge about the physicochemical stability in order to determine the beyond-use-date of the preparations. Therefore, the purpose of this study was to determine the physicochemical stability of carfilzomib solution marketed as Kyprolis® powder for solution for infusion. Reconstituted solutions and ready-to-administer preparations of Kyprolis® stored under refrigeration (2–8℃) or at room temperature (25℃) were analyzed at predetermined intervals over a maximum storage period of 28 days. Chemical stability of carfilzomib wa…