Search results for "Enterocolitis"

Aussagefähigkeit der Abdomenübersichtsaufnahme in der Differenzierung der Rotavirus-negativen und Rotavirus-positiven nekrotisierenden Enterokolitis

1991

Clinical data and radiographic findings of 32 newborn suffering from necrotising enterocolitis were analysed [12 patients with rotavirus-positive necrotising enterocolitis (RV + NEC), 20 patients with rotavirus-negative necrotising enterocolitis (RV-NEC)]. The presence and degree of pneumatosis intestinalis, portal venous gas and pneumoperitoneum on abdominal radiographs were graded after Kosloske et al. according to "mild, moderate, and severe". Pneumatosis intestinalis occurred twice as often in the ascending colon in RV-NEC compared to RV + NEC, whereas the transverse colon was involved nearly as frequently as the descending colon in both groups. Portal venous gas was present in 10% of t…

Rotavirus and non-rotavirus necrotizing enterocolitis

1991

Linezolidtherapie bei zwei Frühgeborenen mit nekrotisierender Enterokolitis und Infektion durch Vancomycin-resistente Enterokokken

2004

The use of the antibiotic Linezolid in two premature babies with necrotizing enterocolitis and infection with vancomycin-resistant enterococcus is described. Therapy with Linezolid in cause of necrotizing enterocolitis is an exception. Actually there are no proven recommendations for the use in this age group. Despite the successfully results more investigations for the use of linezolid in newborns and prematures are necessary.

Current status of laboratory and imaging diagnosis of neonatal necrotizing enterocolitis

2018

Abstract Necrotizing enterocolitis continues to be a devastating disease process for very low birth weight infants in Neonatal Intensive Care Units. The aetiology and pathogenesis of necrotizing enterocolitis are not definitively understood. It is known that necrotizing enterocolitis is secondary to a complex interaction of multiple factors that results in mucosal damage, which leads to intestinal ischemia and necrosis. Advances in neonatal care, including resuscitation and ventilation support technology, have seen increased survival rates among premature neonates and a concomitant detection in the incidence of this intestinal disease. Diagnosis can be difficult, and identifying infants at …

Resveratrol-induced xenophagy promotes intracellular bacteria clearance in intestinal epithelial cells and macrophages

2019

International audience; Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be bene ficial. Here, we show that resveratrol is able to boost xenophagy, a selective form of autophagy that target invasive bacteria. We demonstrated that resveratrol promotes in vitro autophagy-dependent clearance of intracellular bacteria in intestinal epithelial cells and macrophages. These results were validated in vivo using infection in a transgenic GFP-LC3 zebra f…

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1beta, IL-6, TNF-alpha, COX-2, and a…

2012

Pathogenic or non-pathogenic bacteria from flora may play a key role in inflammatory bowel disease (IBD) pathogenesis. However, a specific infectious agent causing IBD has not been identified. This study assessed the impact of enteropathogenic E. coli (EPEC) on the modulation of IL-1beta, IL-6, TNF- alpha, COX-2, BAX and Bcl-2 expression, in sustaining inflammation of a rat colitis model. Two hundred male Sprague-Dawley rats (4 groups) were inoculated weekly or bi-weekly for 70 days, with 1 percent methylcellulose (MC), (b) 6 percent iodoacetamide (IA) in 1 percent MC, (c) 4x108 CFU of EPEC, and (d) IA+EPEC. After a month, treatment was stopped in half of the animals in each group. IL-1beta…

Interés de los índices clínicos en el tratamiento quirúrgico de la enterocolitis necrotizante

2015

INTRODUCCIÓN: Uno de los retos fundamentales de la terapia quirúrgica de los neonatos con enterocolitis necrotizante es decidir el momento adecuado para la intervención. Los índices clínicos pueden mejorar el proceso de toma de decisiones en beneficio del paciente: el MDAS (Metabolic Derangement Acuity Score) y el SNAPPE-II (Score for Neonatal Acute Physiology Perinatal Extension-II) son dos índices clínicos que fueron propuestos como buenas pruebas para decir qué pacientes con enterocolitis necrotizante necesitaban tratamiento quirúrgico; no obstante, su rendimiento diagnóstico como predictores de dicho tratamiento quirúrgico no fue calculado. El objetivo de esta investigación fue obtener …

Aussagefähigkeit und Stellenwert von bildgebender Diagnostik und Duplexsonographie bei Neugeborenen mit nekrotisierender Enterokolitis

1994

In this prospective study 101 sonographic examinations of superior mesenteric artery blood flow velocities, indices and blood flow volume were consecutively performed in 41 newborn to diagnose necrotising enterocolitis (NEC). Intramural and portal venous gas was also estimated. The artifacts of air in the AMS and the portal system were examined in an experimental study. The results of sonography and abdominal radiography were equivalent in the case of definitely established NEC, portal venous gas being more sensitive to detection by sonography. Abdominal radiography was indicated as the primary examination in case of a clearly identified clinical course. Sonography should be performed so th…

Congenital malformations and perinatal morbidity associated with intestinal neuronal dysplasia.

1998

A close relation between different forms of dysganglionosis such as intestinal neuronal dysplasia (IND) type B and aganglionosis has been established. No systematic analysis of other malformations and diseases accompanying IND has been made as yet. Congenital malformations and perinatal morbidity were analyzed in 109 patients with IND seen at the Department of Pediatric Surgery in Mainz from 1977 to 1996. IND was associated with Hirschsprung's disease in 47 cases; 22 children with IND had other abdominal malformations, including anal atresia, rectal stenosis, sigmoidal stenosis, ileal atresia, pyloric stenosis, and esophageal atresia. A cystic bowel duplication, a choledochal cyst, and a pe…

Análisis de los factores epidemiológicos y clínicos implicados en el desarrollo de la enterocolitis necrosante

2015

La enterocolitis necrosante (ENC) es una de los procesos patológicos neonatales más graves por su elevada mortalidad (30%) y complicaciones. A pesar de los constantes avances en la atención neonatal su incidencia continua siendo elevada en el recién nacido pretérmino (RNPT), especialmente en los de peso al nacimiento inferior a 1500 g en los que se estima del 7-10%, tasa que ha sufrido escasas variaciones en los últimos años. La ECN es una enfermedad de origen multifactorial, y la sintomatología inicial muy inespecífica. Se diseñó un estudio en dos fases. En una primera fase se analizaron las características epidemiológicas y clínicas de todos los RNPT ingresados en una unidad IIIA desde 20…