Search results for "Environment"
showing 10 items of 28487 documents
Role of Type I and II Interferons in Colorectal Cancer and Melanoma
2017
Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development. In particular, type I and II interferons are involved in a plethora of mechanisms that regulate immune responses in cancer, thus balancing immune escape versus immune surveillance. Interferons are involved in both the direct and indirect regulation of cancer cell proliferation and metastatic potential. The mutational background of genes involved in interferons signaling could serve as a prognostic biomarker and a powerful tool to screen cancer patients elig…
Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on B…
2020
Copyright © 2020 Murugaiah, Agostinis, Varghese, Belmonte, Vieni, Alaql, Alrokayan, Khan, Kaur, Roberts, Madan, Bulla and Kishore. Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as is a potent innate immune molecule and offers protection against non-self and altered self-such as pathogens, allergens, and tumour. Here, we examined the effect of a recombinant fragment of human SP-D (rfhSP-D) on a range of breast cancer lines. Breast cancer has four molecular subtypes characterised by varied expression of oes…
Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…
Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment.
2014
There is increasing clinical evidence indicating that the immune system may either promote or inhibit tumor progression. Several studies have demonstrated that tumors undergoing remission are largely infiltrated by T lymphocytes [tumor-infiltrating lymphocytes (TILs)], but on the other hand, several studies have shown that tumors may be infiltrated by TILs endowed with suppressive features, suggesting that TILs are rather associated with tumor progression and unfavorable prognosis. γδ T lymphocytes are an important component of TILs that may contribute to tumor immunosurveillance, as also suggested by promising reports from several small phase-I clinical trials. Typically, γδ T lymphocytes …
The effect of residential urban greenness on allergic respiratory diseases in youth: A narrative review
2020
Abstract Background Environmental exposures across the life course may be a contributor to the increased worldwide prevalence of respiratory and allergic diseases occurring in the last decades. Asthma and rhinoconjunctivitis especially contribute to the global burden of disease. Greenness has been suggested to have beneficial effects in terms of reduction of occurrence of allergic respiratory diseases. However, the available evidence of a relationship between urban greenness and childhood health outcomes is not yet conclusive. The current review aimed at investigating the current state of evidence, exploring the relationship between children's exposure to residential urban greenness and dev…
Evaluating Safety Systems for Machine Tools with Computer Numerical Control using Analytic Hierarchy Process
2019
Computer numerical control (CNC) machine tools are complex production systems with fully automatic machine parts. Nowadays, high feed rates and machining speeds are used during the machining process. Human operators are still needed to set-up the machine, load/unload workpieces and parts, load the machining code, and supervise the machining process. The operators work in an environment where automated high-speed motions occur, and consequently, CNC machine tools have to be equipped with safety systems. The approach presented in this paper was to evaluate the main safety systems of CNC machine tools based upon the analytic hierarchy process (AHP). The analyzed systems were divided into six m…
La interacción cooperativa: condición social de aprendizaje
2003
No cabe duda de que la naturaleza de la práctica educativa es fundamentalmente social, un proceso en el que las personas discurren e interactúan mutuamente como parte de una red de influencias sociales definidas y deliberadas: «[ ... ] la educación es la revelación de los demás, de la condición humana como concierto de complicidades irremediables» (Savater 2001: 35). Sin embargo, al ser la educación un tipo de interacción social intencional, no se puede dejar de destacar que la forma en que se organiza esta interacción en los procesos sociales con fines formativos, como los que ocurren en la escuela, tenga consecuencias importantes en los resultados del aprendizaje, es decir, en los proceso…
VIRTUAL CLASSROOM: TEACHER SKILLS TO PROMOTE STUDENT ENGAGEMENT
2018
The Virtual Classroom is the main tool for blended learning, since it allows the breaking of time and space barriers between the teacher and the student. In order to develop and put into practice a higher studies course through this tool, teachers need to have a series of skills related to the command of digital technologies and an understanding of students’ affective and behavioral states: and to then apply appropriate communication strategies to deliver course content and prepare students for this innovative learning approach. This study reviews educational research literature on virtual classrooms, teacher behavior and student engagement to establish a theoretical model that explains the…
Modernities in the Americas: from the avant-gardes to nowadays
2018
Revisiting today the question of modernity in literature, in the arts, in society and politics means using the plural. And choosing the plural means not restricting the scope to the multivocal, but often ambiguous, notion of modernism. Often enrolled to designate a cultural imagination of modernity, the term is under duress when it comes to accounting for divergent ways of apprehending the relationship to time, history and culture. “Modernity is not a movement like dada or like imagism. If li...
Modernidades en las Américas: de las vanguardias a la actualidad
2018
Replantear hoy en día la cuestión de la modernidad —literaria, artística, social o política— equivale a emplear la palabra en plural. Esta decisión supone no limitarse al término polisémico, y a menudo ambiguo, de modernismo. Este último, que con frecuencia se invoca para designar el imaginario cultural de la modernidad, apenas sirve para dar cuenta de las diferencias que se manifiestan en la manera de concebir la relación con el tiempo, la historia y la cultura. «La modernidad no es un movim...