Search results for "Eosin"

showing 5 items of 275 documents

Single and Synergistic Effects of Type 2 Cytokines on Eosinophils and Asthma Hallmarks

2020

Abstract The type 2 cytokines IL-5, IL-13, and IL-4 play an important role in the induction and progression of asthma. According to the Global Initiative for Asthma guidelines, blood eosinophil numbers are one marker that helps to guide treatment decisions in patients suffering from severe forms of asthma. Effects of type 2 cytokines were analyzed, alone or in combination, on eosinophils in blood and other compartments and on the development of asthma symptoms. C57BL/6 mice received a single intranasal application of equimolar amounts of IL-5, IL-13, and IL-4, alone or in combination. Numbers, activation state, and migratory behavior of eosinophils in bone marrow (BM), blood, lung, and bron…

medicine.medical_treatmentImmunologyMedizinMice03 medical and health sciencesTh2 Cells0302 clinical medicineMetaplasiamedicineAnimalsHumansImmunology and AllergyEosinophiliaLungCells CulturedAsthmaGoblet cellInterleukin-13Lungmedicine.diagnostic_testbusiness.industryrespiratory systemEosinophilmedicine.diseaseAsthmarespiratory tract diseasesEosinophilsMice Inbred C57BLDisease Models AnimalBronchoalveolar lavagemedicine.anatomical_structureCytokineImmunologyAirway RemodelingFemaleInterleukin-4Interleukin-5medicine.symptombusiness030215 immunologyThe Journal of Immunology
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Correlaciones clínicas, morfológicas y de calidad de vida en pacientes afectos de rinosinusitis crónica con poliposis nasal

2021

INTRODUCCIÓN La rinosinusitis crónica con pólipos nasosinusales (RSCcPN) es una en-fermedad desafiante que tiene un impacto significativo en la calidad de vida (CdV) de los pacientes. Los eosinófilos se consideran las células in-flamatorias más importantes en la patogénesis de la rinosinusitis con pólipos nasales. La posibilidad de predecir la CdV en los pacientes con RSCcPN permitiría optimizar su manejo y mejorar los resultados. OBJETIVO Conocer la asociación entre la CdV mediante el cuestionario Sinonasal Outcome Test -22 (SNOT-22) y parámetros histopatológicos y molecula-res (incluyendo eosinofilia y expresión de Mucina 1 –MUC1) en pacien-tes con RSCcPN. Los objetivos secundarios incluy…

rinosinusitis crónicaSNOT-22UNESCO::CIENCIAS MÉDICAScalidad de vidaeosinófilos:CIENCIAS MÉDICAS [UNESCO]poliposis nasosinusalmucina 1
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Real-world experience with dupilumab in severe asthma: One-year data from an italian named patient program

2021

Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Beghè,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 1Respiratory Medicine Unit, A.O.U. Policlinico “G. Rodolico -San Marco”, Catania, Italy; 2Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy; 3Respiratory Medicine Unit, Department of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 4Allergy Unit, Department of Internal Medicine, Ancona University Hospital, Ancona, Italy; 5Department of Car…

severe asthmaPulmonary and Respiratory MedicineSevere asthmareal-worldmedicine.medical_specialtyTreatment responseSevere asthmaSocio-culturaleDupilumab Named Patient Program Oral corticosteroids Real-world Severe asthmaHypereosinophiliaDupilumaboral corticosteroidsSettore MED/10 - Malattie Dell'Apparato Respiratoriolaw.inventionNamed Patient Program dupilumab oral corticosteroids real-world severe asthma03 medical and health sciences0302 clinical medicineRandomized controlled triallawdupilumabInternal medicineOral corticosteroidsJournal of Asthma and AllergymedicineImmunology and Allergy0601 history and archaeologyOriginal Research060102 archaeologybusiness.industryRetrospective cohort study06 humanities and the artsRC581-607Named Patient ProgramEosinophilDupilumabmedicine.anatomical_structureReal-world030228 respiratory systemCohortImmunologic diseases. Allergymedicine.symptombusinessDupilumab; Named Patient Program; Oral corticosteroids; Real-world; Severe asthma
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Tumor-associated tissue eosinophilia in tongue squamous cell carcinoma

2020

squamous cell carcinomatongueeosinophilia
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Zvaigznes HD235858 augstas izšķirtspējas spektroskopija un modelēšana

2017

Izmantojot augstas izšķirtspējas spektrus, noteikta 30 dažādu ķīmisko elementu koncentrācija zvaigznes HD235858 fotosfērā, tostarp diviem elementiem (Sr un Mo) koncentrācijas novērtētas pirmo reizi. Novērotas zvaigznes spektra izmaiņas laika gaitā un to izcelsme saistīta ar oglekli saturošo molekulu (C2 un CN) formēšanos ārējos zvaigznes atmosfēras slāņos. Secināts, ka visticamākais iemesls ķīmisko elementu koncentrāciju nesakritībām vairāku autori starpā, ir zvaigznes spektra mainīgums un apjomīgā spektrāllīniju blendēšanās. No elementu daudzuma sadalījuma HD235858 fotosfērā izspriests, ka zvaigzne radusies vidē, kas bijusi bagātināta ar pārnovu sprādzienu atliekām.

zvaigžņu spektroskopijaAGB zvaigznesFizikapost-AGB zvaigzness-procesa nukleosintēze
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