Search results for "Epigénétique"
showing 3 items of 3 documents
Mechanisms involved in the transmission of epigenetic deregulation : analyses of transmission in human sperm
2018
The notion that environmental exposure can be memorized and promote epimutation (defined as defects on DNA methylation) raises the question of possible epigenetic transgenerational transmission in humans. To address whether an epimutation could be transmitted in humans, we pursued two axes. First, the evaluation of intergenerational transmission in the family of a Silver-Russell patient has shown, for the first time, the efficiency of epigenetic reprogramming in humans, specifically on imprinted regions. Indeed, no imprinted defect on causal H19/IGF2 locus was detected in the patient’s spermatozoa or in the DNA of his daughter. The second axis was to assess the presence of sperm epimutation…
Développement postnatal et évolution du complexe craniofacial chezles rongeurs
2022
Understanding developmental mechanisms in evolution is crucial to apprehend the diversification of organismal forms. In mammals, changes occur during all development phases (prenatal and postnatal). Postnatal growth plays an essential role in the acquisition of the adult shape. During this period, the craniofacial complex undergoes many changes in functional constraint forcing the different tissue to accommodate while adjusting, along the growth and at the adult stage, to a certain level of functional performance. These different developmental interactions respond to several influencing factors such as molecular, genetic and cellular processes but also the environment. The latter will play …
Control of the HOXA9 gene expression in the hematopoietic stem/progenitor cells : role of the epigenetic factors MOZ, MLL and of the polyadenylation …
2013
My thesis project has consisted of the study of MOZ, and MLL. They are epigenetic regulators. MOZ and MLL activate transcription of HOX genes, which are transcription factors essential during haematopoiesis. MOZ and MLL have some target genes in common. In our study, we characterised a cooperation between MOZ and MLL in human haematopoietic stem/progenitor cells CD34+. They are both recruited onto HOX promoters. MOZ is essential for MLL recruitment, and this is reciprocal. In conclusion, we provided an example of a mechanism involving a direct cross-talk between two histone modifying enzymes.In order to dissect the mechanism of action of this complex, we decided to identify novel proteins i…