Search results for "Equipo"
showing 10 items of 88 documents
DEBATMITAL 2.0: 2ª Edición de los debates sobre mitos en alimentación
2020
[ES] En la segunda edición del DEBATMITAL, se ha vuelto a utilizar el debate como herramienta docente para abordar el tema de los Mitos en la Alimentación, en la asignatura optativa del Grado en Medicina de la Universitat de Valencia, “Alimentación y Dietética”. Como novedad respecto a la edición pasada, este curso se ha debatido sobre temas de actualidad acerca de la alimentación, sobre los que existe controversia real en la comunidad científica. Los alumnos han valorado la actividad aún más positivamente este curso: la vuelven a preferir respecto a la lección magistal y además creen que les ayuda a adquirir varias competencias propias de su grado. En base a esta experiencia, se consolida …
De la atención de los problemas de la audición y lenguaje a la logopedia como disciplina
2015
Las dificultades del lenguaje han estado presentes en el ser humano desde la antigüedad. La sensibilización social e institucional hacia este tipo de trastornos ha mejorado lentamente hasta nuestros días. Ya en la Edad Moderna (siglos XVI al XVIII) se informa de educación de sujetos con problemas de lenguaje. Destaca el trabajo de Pedro Ponce de León como precursor del tratamiento estas dificultades. De forma progresiva, se tomó conciencia de la importancia del tratamiento de las dificultades del lenguaje. En los siglos XIX y XX se produce la institucionalización de la atención a personas con trastornos del lenguaje. La Orientación Educativa atiende tradicionalmente esta problemática. Poste…
Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases
2022
Population screening; Liver fibrosis; Early diagnosis Cribratge de població; Fibrosi hepàtica; Diagnòstic precoç Cribado de población; Fibrosis hepática; Diagnóstico precoz Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non-alcoholic fatty liver disease and alcohol-related liver disease, although chronic hepatitis B and C infections are still major etiological factors in some areas of the world. Recent studies have shown that liver fibrosis can be assessed with relatively high accuracy noninvasively by serological tests, transient elastography, and radiological methods. Thes…
Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors
2020
Inhibidor d'AKT; Càncer avançat; Fase I Inhibidor de AKT; Cáncer avanzado; Fase I AKT inhibitor; Advanced cancer; Phase I Background This phase Ib study evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of the oral AKT inhibitor ipatasertib and chemotherapy or hormonal therapy in patients with advanced or metastatic solid tumors to determine combined dose-limiting toxicities (DLTs), maximum tolerated dose, and recommended phase II doses and schedules. Patients and methods The clinical study comprised four combination treatment arms: arm A (with docetaxel), arm B [with mFOLFOX6 (modified leucovorin, 5-fluorouracil, and oxaliplatin)], arm C (with paclitaxel), and …
Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor
2017
Prevenció; Atac d'angioedema; Inhibidor C1 Prevención; Ataque de angioedema; Inhibidor C1 Prevention; Angioedema attack; C1 inhibitor BACKGROUND: Hereditary angioedema is a disabling, potentially fatal condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use of CSL830, a nanofiltered C1 inhibitor preparation that is suitable for subcutaneous injection, resulted in functional levels of C1 inhibitor activity that would be expected to provide effective prophylaxis of attacks. METHODS: We conducted an international, prospective, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase 3 trial to evaluate the …
“Near-TME”: proposed standardisation of the technique for proctectomy in male patients with ulcerative colitis
2022
Abstract Background The aim of the present study was to describe in detail an approach to proctectomy in ulcerative colitis (UC), which can be standardized; near-total mesorectal excision (near-TME), to prevent injuries to autonomic pelvic nerves and subsequent sexual dysfunction. Methods We demonstrate the technique ex vivo on a cadaver from a male patient in lithotomy position and on a sagittal section of a male pelvis. We also demonstrate the technique in vivo in two male patients diagnosed with UC, with no history of sexual dysfunction or bowel neoplasia. The study was performed at the Human Embryology and Anatomy Department. University of Valencia, Spain. Results The posterolateral dis…
The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma …
2021
Inhibidor de KIF11; Terapias dirigidas; Metástasis Inhibidor de KIF11; Teràpies dirigides; Metàstasi KIF11 inhibitor; Targeted therapies; Metastasis In summary, our study provides a rationale for the future therapeutic integration in clinical trials of 4SC-205, an structurally distinct oral KIF11 inhibitor that shows potent antitumor activity in multiple preclinical neuroblastoma models and sensitizes neuroblastoma cells to standard chemotherapy and specific neuroblastoma-targeted therapies. The financial support for this research was provided by Instituto de Salud Calos III (PI20/00530 to Miguel F. Segura; PI20/01107 to Rosa Noguera; PI17/02248 and CPII18/00027 to Anna Santamaria; PI19/013…
I traffici illeciti nel Mediterraneo. Persone, stupefacenti, tabacco
2019
Attraverso la combinazione di ricerca criminologica e giuridico-normativa, e grazie anche alla collaborazione con esperti esterni (studiosi, magistrati, rappresentanti di istituzioni italiane e straniere), la ricerca da cui scaturisce il volume ha indagato le interazioni tra i diversi traffici illeciti e la criminalità organizzata nel bacino del Mediterraneo. In tale area, storicamente cruciale per la mobilità di persone e di beni, l’attenzione si è rivolta in particolare ai fenomeni del traffico e della tratta di persone, del traffico di stupefacenti e del contrabbando di sigarette. I contributi raccolti – unitamente al rapporto criminologico e ai cinque rapporti nazionali accessibili su w…
The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Tri…
2021
This article belongs to the Collection The Biomarkers for the Diagnosis and Prognosis in Cancer.
First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study
2021
Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…