Search results for "Equivalence"
showing 10 items of 301 documents
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Carbamazepine.
2020
Abstract Literature relevant to assessing whether BCS-based biowaivers can be applied to immediate release (IR) solid oral dosage forms containing carbamazepine as the single active pharmaceutical ingredient are reviewed. Carbamazepine, which is used for the prophylactic therapy of epilepsy, is a non-ionizable drug that cannot be considered “highly soluble” across the range of pH values usually encountered in the upper gastrointestinal tract. Furthermore, evidence in the open literature suggests that carbamazepine is a BCS Class 2 drug. Nevertheless, the oral absolute bioavailability of carbamazepine lies between 70 and 78% and both in vivo and in vitro data support the classification of ca…
Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.
2012
A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequi…
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate.
2019
Literature data and results of experimental studies relevant to the decision to allow waiver of bioequivalence studies in humans for the approval of immediate release solid oral dosage forms containing cephalexin monohydrate are presented. Solubility studies were performed in accordance with the current biowaiver guidelines of the Food and Drug Administration, World Health Organization and European Medicines Agency, taking the degradation at some pH values into consideration. Together with solubility and permeability data for cephalexin monohydrate from the literature, it was demonstrated to be a Biopharmaceutics Classification System Class 1 drug. The pharmacokinetic behavior, results of b…
Measuring Social Mobility
1993
Abstract The paper considers the ranking of mobility matrices in a simple Markov model of social mobility. The approach is the dynamic counterpart ot the "static" inequality ranking of income distributions by the Lorenz curve. The derived partial ordering is motivated by welfare considerations, is shown to be equivalent to same intuitive mobility concepts, and is used to screen some immobility indices. The equivalence of the ranking with the "permanent income" Lorenz ordering gives support to the claim that this approach is the natural extension of Kolm′s [The optimal production of social justice, in "Public Economics (J. Margolis and H. Guitton, Eds.), MacMillan, London, 1969], Atkinson′s …
The untranslatability of a text and the non-equivalence of words
2020
This article deals with the current state of development of two main categories of modern translation theory: “untranslatability” and “non-equivalence”. Untranslatability belongs to translation-theoretic universals and is a binary category. The essence of the phenomenon, its nature, as well as such concepts as “translation losses”, “untranslatable units”, “translatological classification of text types” are considered. The differences in the meaning of the concepts “untranslatability” and “non-equivalence” are described. The article objective is to show actuality and pecularity of their manifistation in the context of the Russian and German languages.
Estudio piloto de la validez convergente de la adaptación española del Denison Organizational Culture Survey
2016
espanolEl (DOCS, Cuestionario de Cultura Organizacional de Denison) es uno de los instrumentos mas utilizados en el analisis de la cultura organizacional. El objetivo de este articulo es analizar la validez convergente de la version en espanol del DOCS. Para ello hemos empleado otro instrumento de gran relevancia y utilizacion en el campo de la psicologia de las organizaciones, el Organizational Culture Inventory (OCI, Inventario de Cultura Organizacional) de Cooke y Lafferty. Hemos evaluado la validez convergente de estos cuestionarios por medio de correlaciones de Pearson, utilizando una muestra de 344 miembros de una universidad espanola pertenecientes a diferentes equipos de investigaci…
Passive-damping design for vibration control of large structures
2013
In this work, a systematic strategy to design passive damping systems for structural vibration control is presented. The proposed design methodology is based on the equivalence between decentralized static velocity-feedback controllers and passive damping systems. By using recent developments in static output-feedback control, the design of passivedamping systems can be formulated as a single optimization problem with Linear Matrix Inequality constraints. Moreover, this optimization problem can be efficiently solved with standard numerical tools, even for large dimension systems. Due to its computational effectiveness, the proposed methodology can be applied to the design of passive damping…
Probabilistic entailment in the setting of coherence: The role of quasi conjunction and inclusion relation
2013
In this paper, by adopting a coherence-based probabilistic approach to default reasoning, we focus the study on the logical operation of quasi conjunction and the Goodman-Nguyen inclusion relation for conditional events. We recall that quasi conjunction is a basic notion for defining consistency of conditional knowledge bases. By deepening some results given in a previous paper we show that, given any finite family of conditional events F and any nonempty subset S of F, the family F p-entails the quasi conjunction C(S); then, given any conditional event E|H, we analyze the equivalence between p-entailment of E|H from F and p-entailment of E|H from C(S), where S is some nonempty subset of F.…
Finite Satisfiability of the Two-Variable Guarded Fragment with Transitive Guards and Related Variants
2018
We consider extensions of the two-variable guarded fragment, GF2, where distinguished binary predicates that occur only in guards are required to be interpreted in a special way (as transitive relations, equivalence relations, pre-orders or partial orders). We prove that the only fragment that retains the finite (exponential) model property is GF2 with equivalence guards without equality. For remaining fragments we show that the size of a minimal finite model is at most doubly exponential. To obtain the result we invent a strategy of building finite models that are formed from a number of multidimensional grids placed over a cylindrical surface. The construction yields a 2NExpTime-upper bou…
All Classical Adversary Methods Are Equivalent for Total Functions
2017
We show that all known classical adversary lower bounds on randomized query complexity are equivalent for total functions and are equal to the fractional block sensitivity fbs( f ). That includes the Kolmogorov complexity bound of Laplante and Magniez and the earlier relational adversary bound of Aaronson. This equivalence also implies that for total functions, the relational adversary is equivalent to a simpler lower bound, which we call rank-1 relational adversary. For partial functions, we show unbounded separations between fbs( f ) and other adversary bounds, as well as between the adversary bounds themselves. We also show that, for partial functions, fractional block sensitivity canno…