Search results for "Erk"

Yksittäisestä matkailuyrityksestä yritysten väliseen yhteistyöhön : aluekehityksen mahdollisuuksia etsimässä : case Peurungan matkailualue

2010

Tässä tutkimuksessa tutkittiin Peurungan matkailuyritysten välistä yhteistyötä. Tutkimus on kvalitatiivinen tapaustutkimus. Tutkimuksessa oltiin kiinnostuneita siitä, minkälaisena asiakasrajapinnassa toimivat yritykset kokivat yritysten välisen yhteistyön. Tutkimuksessa keskityttiin siihen, minkälaisia mielikuvia tai kokemuksia yhteistyöstä oli toimijoille syntynyt, minkälaista yhteistyötä toimijat olivat odottaneet ja minkälaisena yhteistyö Peurungan alueella koettiin. Lisäksi haastateltavilta pyydettiin ajatuksia siitä kuinka yhteistyön tulisi toimia tulevaisuudessa. Haastateluun pyydettiin 43 yritystä, joista 19 haastateltiin. Peurungan osalta haastateltiin erikseen kolmea henkilöä, mutt…

Kotimaani ompi Suomi : Laulumerkki-hankkeen suomikuva

2008

Bereiche der lexikalischen Kompetenz in Wortschatzübungen anhand der Lehrbuchserien 'In Touch' und 'Genau'

2009

Tuberkulins un tuberkulina reakcijas

1929

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

2020

Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed. Methods: We deprived HCC cells of glutamine to induce metabolic alterations and performed various assays, including metabolomics (with 13C-glucose isotope tracing), microarray analysis, and cell proliferation assays. Glutamine-deprived cells were also treated with kinase inhibitors (e.g. Sorafenib, Erlotinib, U0126 amongst other MEK inhibitors). …

Frictionless contact-detachment analysis: iterative linear complementarity and quadratic programming approaches.

2012

The object of the paper concerns a consistent formulation of the classical Signorini’s theory regarding the frictionless contact problem between two elastic bodies in the hypothesis of small displacements and strains. The employment of the symmetric Galerkin boundary element method, based on boundary discrete quantities, makes it possible to distinguish two different boundary types, one in contact as the zone of potential detachment, called the real boundary, the other detached as the zone of potential contact, called the virtual boundary. The contact-detachment problem is decomposed into two sub-problems: one is purely elastic, the other regards the contact condition. Following this method…

Negotiating digital surveillance legislation in post-Snowden times : An argumentation analysis of Finnish political discourse

2019

Abstract In the digital era, when security agencies world-wide have been challenging basic democratic principles with massive data gathering, Finland has had a different approach: it has conducted no large-scale surveillance of citizens’ online activities. Now, however, the country is planning such a vast expansion of state surveillance that the constitution itself must be altered. The present article examines one key point in this legislative process to see how the new surveillance measures are argued for and criticized, and how the differing points of view are negotiated to ultimately enable political action. Drawing particularly on Fairclough and Fairclough’s (2012) approach to argumenta…

Between Two Worlds. German Travellers in Spain and Morocco in the 19th Century

2014

La literatura de viajes, como vehículo privilegiado para documentar relaciones interculturales, es rica en diferentes expresiones y ejemplos de tipología analógica, antitética y recíproca, que resaltan las similitudes y las diferencias entre la nación propia y la extraña. En el caso de los viajeros alemanes cuyo destino era originariamente España, pero que luego, por diversos motivos, también visitaron Marruecos, la percepción de diferencias suele ser doble, como intentaremos mostrar en el siguiente artículo. En la tipología presente en estos relatos de viaje, España funciona como punto de partida. La tipología analógica y la recíproca apenas se dan, ya que Alemania como país de origen suel…

Translation Process Research as Interaction Research: From Mental to Socio-Cognitive Processes

2014

The main methodological approaches used in cognitive translation process research have hitherto been inspired by methods originally developed in the behavioural sciences, especially psychology. This article contends that mainstream experimental research in laboratory settings needs to be complemented with other methodological approaches such as qualitative, ethnographic research in order to be able to account for the situated, embedded and extended aspects of cognition – as described in current cognitive science approaches. In addition, it presents the empirical research design and initial results of an ethnographic field study into the socio-cognitive aspects of translation. The results sh…

Defending either a personal or an assigned standpoint

2018

Abstract This study clarifies whether a specific type of role play supports upper secondary school students’ collaborative argumentation. Data consist of 12 dyadic face-to-face and 12 chat debates. Data analysis focused on the quality of students’ argumentation. Comparisons were made between students who defended standpoints at variance with their personal opinions on the topics, between the two study modes and topics, and by gender. When the students defended a standpoint differing from their personal opinion, the male students engaged in counterargumentation more often than the female students. When, in turn, the students defended their personal standpoint, they produced both counterargum…