Search results for "Eryt"
showing 10 items of 966 documents
Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year’s experience
2020
Background Numerous biochemical datas support the noxious role of anti-inflammatory drugs on immune response. Those observations are often put forward for unfavorable evolution of odontogenic infection but has never been really proven in clinic. The aim of this study is to try to clarify this role based on the collection of the clinical course of odontogenic infections over a 10-year analysis period. Material and Methods The investigators implemented a prospective observational study. The sample was composed of patients managed between January 2004 and December 2014 for severe odontogenic infection based on three criteria: hospital admission, intravenous antibiotic therapy, tooth extraction…
Erythritol-enriched powder and oral biofilm regrowth on dental implants: an in vitro study.
2021
Background Peri-implant mucositis and peri-implantitis are the main biological complications associated with dental implants. Since most authors agree that bacteria play a major etiological role, the main aims of this study were to determine if a formulation of erythritol and chlorhexidine applied with an air polishing system inhibits biofilm regrowth over dental implants and to compare the decontamination capacity of this therapy with that of mechanical removal by saline and gauze. Material and Methods A multispecies biofilm (P. gingivalis, A. actinomycetemcomitans, F. nucleatum, A. naeslundii, V. parvula and S. oralis) was grown for 14 days on 52 dental implants in an artificial mouth. Th…
Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice.
2005
Type I interferons are associated with lupus. Genes that are regulated by IFN-alpha are upregulated in pediatric lupus patients. Gene deletion of the IFN-alpha/beta receptor in experimental lupus-like NZB mice results in reduced disease activity. Conversely, IFN-beta is a well-established treatment in multiple sclerosis, another autoimmune disease. For determining whether IFN-beta treatment is harmful or beneficial in lupus, MRL-Fas(lpr) mice were injected with this type I IFN. Treatment was initiated in MRL-Fas(lpr) mice with mild and advanced disease. IFN-beta was highly effective in prolonging survival and ameliorating the clinical (renal function, proteinuria, splenomegaly, and skin les…
Autorytarna merytokracja — zarys modeluijego legitymizacja na przykładzie Chin
2021
The article analyses the model of authoritarian meritocracy and its legitimisation on the example of the Chinese People’s Republic. The discussed model is based on three principles: 1. power is exercised by a monoparticle elite that legitimises its position on the basis of moral and substantive criteria; 2. patriarchal and anti-democratic governance; 3. the authorities’ policy aims to meet the material needs of citizens, but without granting them political rights. The Communist Party of China in its official narrative, on the one hand, refers to the assumptions of Maoism, but on the other hand, to a much greater extent — especially in the field of economic cases and the operation of the adm…
Meritocratic Justification in Rulemaking and its Criticism Based on the Example of American Regulatory Agencies
2020
Mertytokracja, w zamyśle autora tego pojęcia Michaela Younga, oznaczała powierzenie spra-wowania władzy nad określonymi obszarami życia społecznego osobom posiadającym odpowiednie do tego umiejętności. Skutkiem implementacji założeń merytokratycznych miało być stworzenie systemu, gdzie kluczową rolę w zarządzaniu życiem społecznym pełnić mieli eksperci. Postulat ten odnosił się także do tworzenia regulacji wybranych dziedzin życia społecznego, co powinno zostać powierzone wyspecjalizowanym, profesjonalnym podmiotom. Autor omawia znaczenie i rolę uzasadnienia merytokratycznego dla prawodawstwa na przykładzie amerykańskich agencji regulacyjnych. Uzasadnienie to ma dwojakie znaczenie: 1) jako …
Modelización de riesgos climáticos y sistemas de vigilancia y alerta en la Comunitat Valenciana
2013
El primer objetivo de esta Tesis está relacionado con el desarrollo e implementación de diferentes sistemas de vigilancia y alerta para el territorio de la Comunitat Valenciana: un sistema de predicción meteorológica en tiempo real basado en el modelo atmosférico de mesoescala Regional Atmospheric Modeling System (RAMS) y un sistema de previsión del Índice UV (UVI), basado en el modelo Santa Barbara DISORT Atmospheric Radiative Transfer (SBDART). Además, se propone una metodología que proporciona un entorno computacional adecuado para la administración y coordinación de los diferentes procesos implicados en ambos sistemas de vigilancia. La principal mejora de la predicción UVI es la utiliza…
Wspólna polityka rolna i jej kapitał instytucjonalny w ocenie użytkowników towarowych gospodarstw rolnych regionu opolskiego
2016
Po 10 latach obecności Polski w UE instrumenty Wspólnej Polityki Rolnej wzmocniły rozwój towarowych gospodarstw rolnych, przystosowały je do zarządzania funkcją środowiskową i zapoczątkowały adaptację do gospodarki opartej na wiedzy. Praca jest próbą odpowiedzi na pytanie o znaczenie WPR oraz jej otoczenia instytucjonalnego dla rozwoju towarowych gospodarstw rolnych i obszarów wiejskich regionu opolskiego. Analizowane są opinie i oceny kierowników tego typu gospodarstw zbierane metodą wywiadu kwestionariuszowego w gospodarstwach zlokalizowanych w gminach reprezentatywnych dla rolnictwa Opolszczyzny. Na podstawie badań z 2008 i 2014 r. stwierdzono, że dalsze procesy transformacyjne w rolnict…
Early Treatment of Systemic Juvenile Idiopathic Arthritis with Canakinumab and Complete Remission After 2 Years of Treatment Suspension: Case Report …
2019
Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease characterised by fever and arthritis. We describe the case of a 14-year-old girl hospitalised with fever associated with rash, myalgia, arthralgia and polyarticular involvement. Examinations revealed increased levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, triglycerides, leukocytes, neutrophils, lactate dehydrogenase, fibrinogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT). Bone marrow biopsy showed polyclonal leukocyte activation. A genetic study revealed a heterozygous mutation of the MEFV gene, c.442G>C (E148Q), which is typical of…
MDS-191: Long-Term Efficacy and Safety of Luspatercept in Lower-Risk Myelodysplastic Syndromes (MDS): Phase 2 PACE-MDS Study
2020
Background: Luspatercept, a first-in-class erythroid maturation agent, has been investigated in patients with LR-MDS and ring sideroblasts (RS) (MEDALIST; Fenaux and Platzbecker NEJM 2020) and in an ongoing Phase 3 trial regardless of RS status (COMMANDS, NCT03682536 ). The previously reported Phase 2 trial of luspatercept (Platzbecker Lanc Onc 2017) includes subtypes of LR-MDS with and without RS, regardless of prior ESA exposure, and various EPO levels. Aims: Evaluate the long-term safety and efficacy of luspatercept in LR-MDS. Methods: Patients were IPSS low/int-1, age ≥ 18 years, Hgb NCT01749514 ; NCT02268383 ). Results: As of 13July2019, 115 patients were enrolled, of whom 108 were tre…
Open-label ODYSSEY APPRISE study: Interim data from the first 843 participants
2018
Background PCSK9 inhibitors (PCSK9i) have been recommended by the ESC/EAS Task Force in very high risk subjects with ASCVD and those with heterozygous familial hypercholesterolemia (HeFH) with persistent high LDL-C levels despite maximally tolerated LLT. Purpose ODYSSEY APPRISE (NCT02476006) is the first study to assess efficacy and safety at Week (W) 12 of the PCSK9i alirocumab (ALI) in a real-life setting prior to commercial availability. Methods APPRISE was an open-label, single-arm study, conducted in 16 European countries and Canada. Subjects with inadequately controlled lipid levels despite maximally tolerated LLT were included. Based on physician's judgment, participants received eit…