Search results for "Esiti"
showing 10 items of 22 documents
Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis : 6-year efficac…
2019
Background To describe the 6-year safety and efficacy of etanercept (ETN) in children with extended oligoarticular juvenile idiopathic arthritis (eoJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA) Methods Patients who completed the 2-year, open-label, phase III CLinical Study In Pediatric Patients of Etanercept for Treatment of ERA, PsA, and Extended Oligoarthritis (CLIPPER) were allowed to enroll in its 8-year long-term extension (CLIPPER2). Children received ETN at a once-weekly dose of 0.8 mg/kg, up to a maximum dose of 50 mg/week. Efficacy assessments included the JIA core set of outcomes, the JIA American College of Rheumatology response criteria (JIA-ACR), and t…
Two-year Efficacy and Safety of Etanercept in Pediatric Patients with Extended Oligoarthritis, Enthesitis-related Arthritis, or Psoriatic Arthritis.
2015
Objective.The main objective was to determine the 2-year clinical benefit and safety of etanercept (ETN) in children with the juvenile idiopathic arthritis (JIA) categories of extended oligoarthritis (eoJIA), enthesitis-related arthritis (ERA), or psoriatic arthritis (PsA).Methods.CLIPPER was a 96-week, phase IIIb, open-label, multicenter study. Patients with eoJIA, ERA, or PsA received ETN 0.8 mg/kg once weekly (50 mg max) for up to 96 weeks. The proportions of patients reaching the JIA American College of Rheumatology (ACR) 30/50/70/90/100 and inactive disease responses at Week 96 were calculated. Adverse events (AE) were collected throughout the study (intention-to-treat sample).Results.…
Effetti della introduzione di indicatori di esito per valutazione della performance delle direzioni aziendali in Sicilia
2012
Negli ultimi anni, il Programma Nazionale Esiti ha acquisito sempre maggiore importanza, come dimostrato dal crescente accesso all’apposito sito web predisposto, nonché dallo sviluppo di programmi di collaborazione tra l’Agenas e le diverse agenzie regionali Scopo del presente contributo è quello di fare un quadro della valutazione degli interventi sanitari in Sicilia, evidenziando le specificità ed i vantaggi dell’implementazione di alcuni indicatori utilizzando le banche dati disponibili a livello regionale. Si vogliono evidenziare i risultati sinora raggiunti con riferimento alla valutazione degli interventi sanitari in Sicilia, nonché le sfide più prossime che si intendono affrontare al…
La "chiarezza dei quesiti referendari in materia elettorale. Brevi riflessioni a proposito di un limite di ammissibilità d'incerta definizione
2012
Alleanza terapeutica, Meccanismi di difesa ed Esiti nel trattamento del DAP. Analisi di una interruzione di trattamento. Uno studio single-case
2008
Teachers and inclusion: an empirical survey on specialist training for support teachers
2019
This paper illustrates the results of an empirical-experimental research conducted as part of the Specialization Course for support activities, held at the University of Palermo in the academic year 2016/17. The survey, concerning the effectiveness of training courses for teachers for the development of active learning, involved 450 teachers and had the main objective of investigating whether there was an actual increase in specific professional skills functional to school inclusion among those who attended the course. Despite leading to different kinds of meaningfulness, the pre/post-test data are evidence of a general positive improvement, highlighting how a student-centred approach has a…
Flare in axial spondyloarthritis. The dark side of the outcome
2016
Spondyloarthritis (SpA) is a chronic inflammatory rheumatic disease with many phenotypes,1 but the frame of the disease is still a matter of debate, particularly regarding the non-radiographic forms of axial SpA.2 ,3 The disease evolution may have several profiles, mainly related to the treatment strategy, balancing from periods of remission or low disease activity to flares of the disease. The recommended treatment strategies are supposed to be tailored to the disease activity, aiming to reach remission or low disease activity in a T2T strategy,4 with management of remission (reduction of dosage or increase in interval of administration), as well as treatment intensification in case of fla…
Emergence of severe spondyloarthropathy-related entheseal pathology following successful vedolizumab therapy for inflammatory bowel disease
2018
Objectives Vedolizumab (VDZ) blocks α4β7 integrin and is licenced for the treatment of IBD. It has been associated with mild SpA-related features, including sacroiliitis and synovitis. Herein we report a series of cases demonstrating the emergence of severe SpA-associated enthesitis/osteitis following successful IBD therapy with VDZ. Methods We evaluated 11 VDZ-treated patients with IBD across seven centres who developed severe active SpA and/or enthesopathy, with the aim of characterizing the VDZ-associated SpA or entheseal flares. Imaging features demonstrating particularly severe disease were recorded. Results De novo SpA developed in 9 of 11 patients and flare of known SpA in 2 patients…
Vaikuttaako emotionaalinen taustamusiikki vihaisten kasvoilmemuutosten esitietoiseen tiedonkäsittelyyn muutossokeusparadigmassa?
2011
Uhkaavat tai vihaiset ärsykkeet havaitaan neutraaleja ja muita emotionaalisia ärsykkeitä tehokkaammin, mikä johtunee tietoisuutta edeltävistä esitietoisista havaintoprosesseista. Usein ympäristön viestit toisaalta havaitaan eri aisti-informaatioita yhdistellen aistipiirien välisen (engl. cross-modal) tiedonkäsittelyn myötä, jolloin nähdyn (emotionaaliseen) käsittelyyn voisi vaikuttaa esimerkiksi samalla kuultu taustamusiikki. Tämän tutkimuksen tarkoituksena oli selvittää uhkan esitietoisen prosessoinnin mahdollisuutta sekä emotionaalisen taustamusiikin roolia visuaalisten uhkaärsykkeiden tiedonkäsittelyssä. Tätä tutkittiin muutossokeusparadigmalla, jossa esitettiin nopeita neutraalista viha…
L'appello
2018
Il contributo analizza l'istituto dell'appello penale. Dopo un inquadramento sistematico dell'istituto, con riguardo alla struttura e la funzione dello stesso, ci si sofferma sui casi di appello, sull'atto e sull'appello incidentale. L'attenzione poi è rivolta alla cognizione del giudice e i poteri decisori. Quindi si affronta il complesso tema del giudizio d'appello, analizzando le novità introdotte dalla c.d. Riforma Orlando in tema di rinnovazione dell'istruzione dibattimentale, della quale vengono individuati i casi di rinnovazione obbligatoria e quelli affidati alla discrezionalità del giudice. L'analisi quindi affronta la controversa questione della natura dell'appello: nuovo giudizio…