Search results for "Esthesioneuroblastoma"
showing 3 items of 3 documents
Esthesioneuroblastoma: Ultrastructural, immunohistological and biochemical investigation of one case
1984
A case of esthesioneuroblastoma, the pathological diagnosis of which almost always causes great difficulties, was investigated ultrastructurally, biochemically, and immunohistologically, using antibodies against the five known types of intermediate filaments [keratin, vimentin, desmin, glial fibrillary acidic protein (GFAP) and neurofilaments]. The tumour cells did not react with antibodies against any of the five intermediate filament proteins. Ultrastructural investigations showed dense cored secretory granules in the cytoplasm and cell processes. Thus, immunohistology offers by "exclusion" a differential diagnosis to avoid often misdiagnosed tumours (undifferentiated carcinomas, embryona…
Pigmented esthesioneuroblastoma showing dual differentiation following transplantation in nude mice
1989
Esthesioneuroblastoma (ESTH) is a neuroepithelial-cell-derived neoplasm of the olfactory mucosa composed of homogeneous small round cells which contain neurosecretory granules. Melanin has been detected in such tumours only occasionally. Here we describe a new case of ESTH with divergent differentiation. The primary neoplasm was found in a 67 year-old female, involving the left nasal and maxillary sinus; she died of cerebral metastasis ten months after diagnosis. Histologically only small round cells were seen, with S-100 and NSE positivity. Electron microscopy revealed neurosecretory granules and filaments, as well as the occasional presence of melanosomes. A nude mice xenograft line has b…
Esthesioneuroblastoma presenting with epifora in a young child
1997
Esthesioneuroblastoma (ENB) is an uncommon tumor believed to arise from the olfactory epithelium. 1 This neoplasm has rarely been reported in children, with only 12 cases reported to date among patients younger than 10 years. 2 The usual initial symptom in children, as in older patients, is nasal obstruction or epistaxis 3 ; consequently, the tumor is often first seen by an otorhinolaryngologist. We report a case of ENB in a young child in whom the initial symptom was epiphora; to our knowledge, this initial symptom is previously unreported, and ENB must now be considered in the differential diagnosis of epiphora in childhood. Report of a Case. A white 6-year-old male child was seen on Janu…