Search results for "Estramustine"

showing 3 items of 3 documents

[11C]choline-PET-guided helical tomotherapy and estramustine in a patient with pelvic-recurrent prostate cancer: local control and toxicity profile a…

2010

[11C]choline positron emission tomograhy can be useful to detect metastatic disease and to localize isolated lymph node relapse after primary treatment in case of prostate-specific antigen failure. In case of lymph node failure in prostate cancer patients, surgery or radiotherapy can be proposed with a curative intent. Some reports have suggested that radiotherapy could have a role in local control of oligometastatic lymph node disease. This is the first reported case of [11C]choline positron emission tomography-guided helical tomotherapy concomitant with estramustine for the treatment of pelvic-recurrent prostate cancer. At 24 months after the end of helical tomotherapy, prostate-specific…

OncologyMaleCancer Researchmedicine.medical_treatment[11C]choline-PET tomotherapy prostate relapse lymph node030218 nuclear medicine & medical imagingCholineProstate cancer0302 clinical medicineProstateCarbon RadioisotopesTomographyLymph nodeAdjuvantPelvic NeoplasmsrelapseprostateGeneral MedicineAlkylatingmedicine.anatomical_structureTreatment OutcomeLocalOncologyChemotherapy Adjuvant030220 oncology & carcinogenesis[11C]choline-PETEstramustineAged; Antineoplastic Agents Alkylating; Antineoplastic Agents Hormonal; Carbon Radioisotopes; Chemotherapy Adjuvant; Choline; Estramustine; Humans; Male; Neoplasm Recurrence Local; Pelvic Neoplasms; Prostatic Neoplasms; Radiotherapy Adjuvant; Treatment Outcome; Positron-Emission Tomography; Tomography Spiral ComputedEstramustinemedicine.drugmedicine.medical_specialtyAntineoplastic Agents HormonaltomotherapyAntineoplastic AgentsTomotherapy03 medical and health sciencesInternal medicinemedicinelymphChemotherapyHumansAntineoplastic Agents AlkylatingAgedChemotherapyHormonalRadiotherapybusiness.industryProstatic Neoplasmsmedicine.diseaseRadiation therapyNeoplasm RecurrenceConcomitantPositron-Emission TomographySpiral ComputedRadiotherapy AdjuvantNeoplasm Recurrence LocalbusinessTomography Spiral Computed
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Oral chemotherapy in hormone-refractory prostate carcinoma patients unwilling to be admitted to hospital.

2008

<i>Objectives:</i> To investigate the safety and efficacy in terms of PSA response of a low-dose oral combination of estramustine phosphate (EMP) and etoposide (VP16) in hormone- refractory prostate cancer (HRPC) patients. Well-tolerated outpatient chemotherapy regimens for patients unfit and/or unwilling to be admitted to hospital are needed. <i>Methods:</i> Fifty-six HRPC patients with metastatic disease (median age 75 years) were randomized between arm A (daily oral EMP 10 mg/kg, in 3 doses) and arm B (28-day cycle with low-dose EMP 3 mg/kg once daily plus VP16 25 mg/m<sup>2</sup> once daily on days 1 through 14). Baseline characteristics between the t…

OncologyMalemedicine.medical_specialtyHormone refractoryOral chemotherapyUrologyUrologyPsa responseAdministration OralAntineoplastic AgentsAdenocarcinomaProstate cancerhormone-refractory prostate carcinoma Oral chemotherapyInternal medicinemedicineEstramustine phosphateHumansEtoposideAgedEtoposideAged 80 and overbusiness.industryProstatic NeoplasmsProstate carcinomaMiddle Agedmedicine.diseaseHospitalizationEstramustinePatient Compliancebusinessmedicine.drugHormoneUrologia internationalis
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Randomized Phase II trial assessing estramustine and vinblastine combination chemotherapy vs estramustine alone in patients with progressive hormone-…

2004

Abstract Based on the results of combined data from three North American Phase II studies, a randomised Phase II study in the same patient population was performed, using combination chemotherapy with estramustine phosphate (EMP) and vinblastine (VBL) in hormone refractory prostate cancer patients. In all, 92 patients were randomised into a Phase II study of oral EMP (10 mg kg day continuously) or oral EMP in combination with intravenous VBL (4 mg m(2) week for 6 weeks, followed by 2 weeks rest). The end points were toxicity and PSA response in both groups, with the option to continue the trial as a Phase III study with time to progression and survival as end points, if sufficient responses…

MaleCancer Researchmedicine.medical_specialtyUrologyAdministration OralPhases of clinical researchVinblastineMetastasisClinicalProstate cancerAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansInfusions IntravenousSurvival analysishormone-escaped prostate cancerEMP/VBL vs EMPbusiness.industryProstatic NeoplasmsCombination chemotherapyProstate-Specific Antigenmedicine.diseaseSurvival AnalysisPhase IISurgeryVinblastineProstate-specific antigenOncologyDrug Resistance NeoplasmDisease ProgressionEstramustineEstramustinebusinessmedicine.drug
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