Search results for "Estro."
showing 10 items of 770 documents
Chronic exposure to a GSM-like signal (mobile phone) does not stimulate the development of DMBA-induced mammary tumors in rats: results of three cons…
2002
Certain epidemiological and experimental studies raised concerns about the safety of radiofrequency (RF) electromagnetic fields because of a possible increased risk of leukemia and lymphoma. In this study, an RF field used in mobile telecommunication was tested using 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in female Sprague-Dawley rats as a model for human breast cancer. Three experiments were carried out under strictly standardized conditions and were started on the same day of three consecutive years. The field consisted of a GSM-like signal (900 MHz pulsed at 217 Hz, pulse width 577 micros) of relatively low power flux density (100 microW/cm(2) +/- 3 dB) and was appl…
Study on the histamine-like activity of guanfacine
1990
Abstract The effects of guanfacine have been studied on guinea-pig isolated atria and diethylstilboestrol-treated rat isolated uterus to determine whether it possesses histamine-like activity. Guanfacine produced a concentration-dependent negative chronotropic effect which was not modified by ranitidine (0.1 μM). In rat isolated uterus contracted by KCl, clonidine (5–5000 μM) produced concentration-dependent relaxation which was blocked by ranitidine (0.1 μM), but guanfacine only produced relaxation at high concentrations (100–1000 μM), and this was not affected by ranitidine (0.1 μM). It is concluded that guanfacine, unlike clonidine, does not produce effects due to activation of H2-recept…
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
2014
Several studies suggest a link between circadian rhythm disturbances and tumorigenesis. However, the association between circadian clock genes and prognosis in breast cancer has not been systematically studied. Therefore, we examined the expression of 17 clock components in tumors from 766 node-negative breast cancer patients that were untreated in both neoadjuvant and adjuvant settings. In addition, their association with metastasis-free survival (MFS) and correlation to clinicopathological parameters were investigated. Aiming to estimate functionality of the clockwork, we studied clock gene expression relationships by correlation analysis. Higher expression of several clock genes (e.g., C…
Alterations in Circulating miRNA Levels following Early-Stage Estrogen Receptor-Positive Breast Cancer Resection in Post-Menopausal Women
2014
INTRODUCTION: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether these alterations were also observed in an independent data set.METHODS: Global miRNA analysis was performed on prospectively collected serum samples from 24 post-menopausal women with estrogen receptor-positive early-stage breast cancer before surgery and 3 weeks after tumor resection using global LNA-based quantitative real-time PCR (qPCR).RESULTS: Numbers of specific miRNAs detected in the samples ranged fro…
Finding the right dose of fulvestrant in breast cancer
2012
Fulvestrant is a selective estrogen receptor downregulator, behaving as a complete antagonist. It was initially approved, at a dose of 250 mg, to treat hormone dependant breast cancer in second line setting. However, a series of pharmacological and pre-clinical studies have suggested that a higher dose of 500 mg may be more effective. The present work summarizes and discusses clinical trials that have aimed to test the benefits of administering fulvestrant at a higher dose. The data support the use of a higher, and more possibly, effective dose of the agent.
Guida in stato di ebbrezza e sequestro/confisca di veicolo intestato a soggetto diverso dal conducente
2011
Si analizza la casistica giurisprudenziale in materia di confisca del veicolo per guida in stato di ebbrezza, nel caso in cui il veicolo appartenga a soggetto diverso dal conducente
Mestres de cases no agremiats a Tarragona i Tortosa a finals del segle XVIII: límits laborals i exclusions
2010
En el presente artículo se exponen algunas de las quejas que debilitaron los principios de los maestros de casas de Tarragona y de Tortosa a finales del siglo XVIII y también se mencionan las controversias que tenían los maestros de este gremio con los afiliados de otros gremios desconocidos. En ocasiones, la solidaridad que los unía se transformaba en arrogancia de cara a otros profesionales que los veían como una auténtica amenaza laboral. Los siguientes conflictos indican que los gremios de Tortosa y el de Tarragona funcionaban como el resto de los gremios de Cataluña, es decir, actuaban siguiendo el espíritu corporativo y laboral de un organigrama de funcionamiento secular. (A)
Theoretical and pedagogical perspectives on orchestrating creativity and collaborative learning
2011
The role of teacher is increasingly related to designing and arranging collaborative learning situations in which fruitful and creative group work may occur. This thematic review presents recent studies on creativity and collaborative learning from the perspective of the teacher as conductor of learning processes. The precondition for the design and orchestration of these kinds of learning situations is analysing and understanding of creative and collaborative processes and their contextual adaption. Thus, the first section of this review focuses on the theoretical vantage points of creativity and collaborative learning mainly from socio-cultural perspective. Based on this theoretical groun…
Artistas viajeros entre Valencia e Italia
2000
El presente artículo resume las principales relaciones existentes entre Valencia e Italia durante parte de los siglos XV y XVI, a través de las noticias de artistas viajeros entre uno y otro punto. Se analizan los viajes y las conexiones artísticas establecidas por escultores, orfebres, pintores o arquitectos y se trata de determinar el posible alcance de esas relaciones y su influencia en el desarrollo artístico de la época.
Male breast cancer.
2010
Male breast cancer (MaleBC) is a rare disease, accounting for <1% of all male tumors. During the last few years, there has been an increase in the incidence of this disease, along with the increase in female breast cancer (FBC). Little is known about the etiology of MaleBC: hormonal, environmental and genetic factors have been reported to be involved in its pathogenesis. Major risk factors include clinical disorders carrying hormonal imbalances, radiation exposure and, in particular, a positive family history (FH) for BC, the latter suggestive of genetic susceptibility. Rare mutations in high-penetrance genes (BRCA1 and BRCA2) confer a high risk of BC development; low-penetrance gene mutati…