Search results for "Estro."
showing 10 items of 770 documents
Estrogen Receptor and Vascular Aging.
2021
Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. Th…
La implicación del alumnado en su propio aprendizaje: Aproximación al concepto de Programación.
2004
La experiencia que presentamos se plantea como respuesta a la necesidad de aprender a programar sentida y expresada por los estudiantes de maestro en un trabajo anterior. Las actividades diseñadas pretenden implicarlos en la construcción del concepto de programación, ayudarles a analizar los presupuestos teóricos que subyacen en las distintas formas de programar con el fin de que tomen conciencia de cómo influye cada una de ellas en la profesionalidad docente, en la idea de escuela y en la forma de enseñar. Este trabajo se inscribe en un proceso de mejora de la metodología universitaria de formación inicial de maestros. Se pretende facilitar un aprendizaje relevante desde la unión de la teo…
Influencia del cambio de uso sobre la erosión del suelo, carbono transportado por erosión y stocks de carbono en ambientes semiáridos mediterráneos
2014
A continuación se describen los temas principales que serán abordados en la tesis doctoral futura: - Relevancia del proceso de erosión hídrica en zonas semiáridas mediterráneas. - Influencia de la erosión en la dinámica del carbono. - Relaciones estructura-Erosión hídrica-Carbono. - Pools de carbono asociados con la erosión hídrica - Contribución de la erosión hídrica a la pérdida de carbono. - Cambio en las propiedades básicas del suelo debido al cambio de uso. - Cambios en la dinámica del carbono asociados a los cambios de uso del suelo - Cuantificación de los diferentes stocks de carbono orgánico en los diferentes usos de suelo. - Efecto de los usos del suelo en el carbono transportado p…
Cuinant cuinant... la millor recepta estadística
2021
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. El suport visual s’aconsegueix gràcies al projecte UV-SFPIE_PID19-1095187 que sustenta aquest treball en el marc Projectes d’innovació educativa i millora de la qualitat docent a la Universitat de València El propòsit d’aquest llibre és acostar els coneixements estadístics al professorat de tots els nivells, des de l’ensenyament primari fins al superior, perquè dispose d’eines objectives per a la millora de la pràctica docent, a la manera d’un mestre cuiner entre els fogons. A fi de complir aquest objectiu, el nostre text es divideix en tres capítols. …
Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.
2010
Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…
Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy
2011
Introduction: Postmenopausal monozygotic twin pairs discordant for hormone replacement therapy (HRT) provide an advantageous study design controlling for genetic background for elucidating the relationships between aging, sex hormone levels, muscle strength, contractile capacity, and fatigability. Methods: Thirteen postmenopausal monozygotic twin pairs discordant for HRT were measured for maximal voluntary torque (MVC) and twitch characteristics using electrical stimulation before and after intermittent dynamic plantarflexor exercise until exhaustion. Results: Peak twitch torque was 32% higher in HRT users than in their non-HRT, genetically identical sisters (P = 0.002), but MVC did not dif…
Strategic and motivational factors as predictors of pre-service primary teachers's success in problem solving
2014
En este trabajo se presenta una investigación descriptiva que muestra las relaciones entre cinco factores motivacionales y estratégicos (planificación, estrategias cognitivas, autocontrol, esfuerzo y autoeficacia) y el rendimiento en la resolución de problemas. Se administró a 66 maestras y maestros de primaria en formación un cuadernillo con dos problemas (problema 1 y problema 2) y el test de O'Neil y Schacter. Los resultados de los análisis de regresión múltiple ponen de manifiesto que: a) planificación, esfuerzo y autoeficacia son predictores significativos de las puntuaciones de las puntuaciones del problema de estructura simple (problema 1); b) esfuerzo, autoeficacia y estrategias cog…
Estradiol deficiency and skeletal muscle apoptosis: Possible contribution of microRNAs.
2020
Background Menopause leads to estradiol (E2) deficiency that is associated with decreases in muscle mass and strength. Here we studied the effect of E2 deficiency on miR-signaling that targets apoptotic pathways. Methods C57BL6 mice were divided into control (normal estrous cycle, n = 8), OVX (E2 deficiency, n = 7) and OVX + E2 groups (E2-pellet, n = 4). Six weeks following the OVX surgery, mice were sacrificed and RNA isolated from gastrocnemius muscles. miR-profiles were studied with Next-generation sequencing (NGS) and candidate miRs verified using qPCR. The target proteins of the miRs were found using in silico analysis and measured at mRNA (qPCR) and protein levels (Western blot). Resu…
Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength.
2019
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of…
Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-re…
2018
Objective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones. Methods: Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were constructed to estimate the association of 17b-estradiol (E…