Search results for "Ethics"

Unpacking the behavioural components and delivery features of early childhood obesity prevention interventions in the TOPCHILD Collaboration: A syste…

2022

ABSTRACTIntroductionLittle is known about how early (e.g., commencing antenatally or in the first 12 months after birth) obesity prevention interventions seek to change behaviour and which components are or are not effective. This study aims to 1) characterise early obesity prevention interventions in terms of target behaviours, delivery features, and behaviour change techniques (BCTs), 2) explore similarities and differences in BCTs used to target behaviours, and 3) explore effectiveness of intervention components in preventing childhood obesity.Methods and analysisAnnual comprehensive systematic searches will be performed in Epub Ahead of Print/MEDLINE, Embase, Cochrane (CENTRAL), CINAHL,…

Autosomal recessive polycystic kidney disease: case report of a newborn with rare PKHD1 mutation, rapid renal enlargement and early fatal outcome

2020

Abstract Introduction Autosomal recessive polycystic kidney disease (ARPKD; MIM#263200) is one of the most frequent pediatric renal cystic diseases, with an incidence of 1:20,000. It is caused by mutations of the PKHD1 gene, on chromosome 6p12. The clinical spectrum is highly variable, ranging from late-onset milder forms to severe perinatal manifestations. The management of newborns with severe pulmonary insufficiency is challenging, and causes of early death are sepsis or respiratory failure. In cases of massive renal enlargement, early bilateral nephrectomy and peritoneal dialysis may reduce infant mortality. However, there is no conclusive data on the role of surgery, and decision-makin…

Prematurity and twinning

2012

Aim of the study: Newborns from multiple pregnancies are increasing in number and demonstrate a higher perinatal morbidity and mortality compared to singletons. Prematurity is the main reason for most neonatal diseases in twins, but other variables may play a role and their prenatal evaluation may improve the overall outcome. Main findings: Prematurity is six times more frequent in twins and therefore birth weight is significantly lower compared to singletons. Thus, twins are more exposed to prematurity related diseases (respiratory, cardiovas- cular, infectious, etc.) and to long-term complications (especially neurological disabilities). Results: It is very difficult to estimate the increa…

Aspetti etici e controllo di gestione dei farmaci antibiotici antibatterici

2010

Summary Introduction Antibacterial prescribing practices between 2004 and 2008 were investigated in the P. Giaccone University Hospital in Palermo, Italy to provide a foundation for critical analysis of the appropriateness of health-care resource usage. Materials and methods Antibiotic prescribing practices between 2004 and 2008 were analyzed in the hospital as a whole and in different specialty areas. Results were expressed as defined daily doses (DDD) as a function of bed-days, number of admissions, and Diagnosis Related Group (DRG) points. Results During the study period, increases were observed in the overall DDD per 100 bed-days (68.7 vs. 91.3) and the DDD per admission (4.53 vs. 5.54)…

INTUITION OF FAMILY ENTREPRENEURS: AN EXPLORATORY STUDY OF PERCEPTIONS AND EXPERIENCES

2005

Many business problems do not appear in ideal conditions. Sometimes decisions have to be made very quickly, or there is no explicit knowledge regarding a problem, or there is neither enough time nor enough information. Therefore, entrepreneurs are not always equipped to make the necessary decision or to solve the problem. A successful entrepreneur needs to rely more often on intuition in making decisions and in solving problems. Intuition can be considered, for example, as a sudden awareness of knowledge. Using this type of knowledge, a person knows facts or relations, but without knowing why.Previous studies have described the nature of intuition and they have also addressed the intuitive …

Association between playing tactics and creating scoring opportunities in elite football. A case study in Spanish Football National Team

2015

The aim of this study was to examine the association between playing tactics, situational variables and creating scoring opportunities according to the type of start-up possession in a case-study. All team possessions (n=857) developed by the Spanish Football national team during the World Cup 2010 were analysed and grouped into “strategic set-plays” (n=90), “recoveries” (n=451) and “restarts” (n=316). Fourteen categorical variables which describe offensive playing tactics, opponent situation as well as situational variables and their associations with creating scoring opportunities were examined using chi-square analysis and bivariate logistic regressions. Chi-square analysis showed that “…

La Biología Sintética; reto biotecnológico y bioético en las Ciencias de la Vida

2020

[ES] La Biología Sintética supone un reto científico y bioético de futuro, tanto a nivel medioambiental, como también en el mejoramiento humano y de otras especies. Por ello, el trabajo abordará dos aspectos principalmente. La síntesis en el laboratorio de células artificiales para la fabricación de un principio activo farmacéutico y por otra parte la reflexión bioética acerca de la potencialidad de dichas técnicas, advirtiendo la diferencia en los límites de la síntesis de vida y creación de vida. Actualmente, se calcula que hay 1.7 millones de especies conocidas de las 14 millones que se estima en la naturaleza. En los últimos 10 años se han generado más de 3000 patentes de organismos gen…

Best practice in research – Overcoming common challenges in phytopharmacological research

2019

Abstract Background The pharmacology, toxicology and pharmacokinetics of bioactive preparations derived from natural sources has become a flourishing field of research. However, researching complex extracts and natural products faces numerous challenges. More broadly in recent years the critique of pharmacological research, and specifically its design, the methods used and reporting has intensified. Aims This consensus document provides a perspective on what constitutes best practice in pharmacological research on bioactive preparations derived from natural sources, providing a perspective of what the leading specialist journals in the field consider as the core characteristics of good rese…

Editorial - Current advances in cancer research: Therapeutics, Targets, and Chemical Biology.

2017

A Survey of Danish, German and Spanish Ethics Committees Prior to the 2004 Implementation of the European Directive Covering the International Confer…

2005

Objective and methods In January 2000, a written questionnaire was provided to ethics committees in Denmark, Germany and Spain in order to collect information on the main characteristics and percentages of committees fulfilling Good Clinical Practices (GCP) in accordance with the International Conference of Harmonisation (ICH) guidelines. The committees were also asked to outline their clinical trial-related activities throughout 1999.