Search results for "Evidence"
showing 10 items of 1050 documents
What Counts in the Politics of Climate Change? Science, Scepticism and Emblematic Numbers
2019
Scientific data is frequently presented in climate policy in the form of targets, thresholds and other “emblematic numbers”. Emblematic numbers provide putatively accurate, easily graspable units of comparison. Their use, however, belies the complexity of climate change and scientific data and threatens to mask the political decisions that operate behind them. Those interested in disrupting policymaking are able to expose and exploit this masked politicisation. This contribution unpicks the ambiguous politics of emblematic numbers. A Qualitative Content Analysis of the 2015 NIPCC report reveals the tactics of a climate change denial organisation to target the politics behind “97%” and “95%”…
Balancing and clustering of words in the Burrows–Wheeler transform
2011
AbstractCompression algorithms based on Burrows–Wheeler transform (BWT) take advantage of the fact that the word output of BWT shows a local similarity and then turns out to be highly compressible. The aim of the present paper is to study such “clustering effect” by using notions and methods from Combinatorics on Words.The notion of balance of a word plays a central role in our investigation. Empirical observations suggest that balance is actually the combinatorial property of input word that ensure optimal BWT compression. Moreover, it is reasonable to assume that the more balanced the input word is, the more local similarity we have after BWT (and therefore the better the compression is).…
DNA Evidence Uncompromised by Active Oxygen
2010
Currently, forensic sciences can make use of the potential of instrumental analysis techniques to obtain information from the smallest, even invisible, samples. However, as laboratory techniques improve, so too should the procedures applied in the search for and initial testing of clues in order to be equally effective. This requires continuous revision so that those procedures may resolve the problems that samples present. As far as bloodstains are concerned, there are methods available that are recognized as being both highly sensitive and effective. Nevertheless, the marketing of new cleaning products, those that contain active oxygen, has raised doubts about the ability of those procedu…
Domestic violence in light of the Istanbul Convention: some procedural issues
2021
The paper concerns domestic violence (DV) and focuses on the connected criminal procedure topics. Following an attempt to define DV, the second part of the paper concerns the profile of the victim. The third part of the paper highlights two procedural issues, namely the complaint and the evidence. After that, the duty of the States to grant legal aid is considered.
Pattern of drug use by advanced cancer patients followed at home
2001
The aim of this study was to document the drugs most commonly prescribed to control symptoms in advanced cancer patients being followed at home. We analyzed data for 128 patients admitted to a home palliative care program from January 1993 to January 1995. All patients were followed at home until death by a team consisting of doctors and nurses, and were given two or three medical examinations a week. The most frequently prescribed drugs were analgesics and drugs commonly used to prevent NSAID-induced gastric toxicity. Slow-release morphine was the analgesic used most often. Most patients received more than four drugs. Younger people received morphine more often than did older patients. Co…
Colorectal cancer: pharmacogenetics support for the correct drug prescription
2019
Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practical and accessible rational way, the advances that currently exist for the application of PGx in colorectal cancer chemotherapy management through the study of the patients’ germline polymorphisms. To define the polymorphisms that can be applied, we rely on three fundamental cornerstones: the recommendations of drug regulatory agencies; the implementation guidelines prepared by expert consortia in PGx and information from clinical annotations (the drug/p…
Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.
2007
The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy. Bortezomib is the first proteasome inhibitor to be approved by the US FDA; in 2003 as a third line and in 2005 as a second line therapy for the treatment of multiple myeloma only. This review focuses on the use of bortezomib, not only in its therapeutic role but also, more specifically, in its biologic role and discusses the most recent applications of the drug in solid tumors, both at a preclinical and clinical level.
Evidence-based practice (EBP)
2012
A multicriteria extension of the efficient market hypothesis
2021
Challenging the Efficient Market Hypothesis (EMH) has been a recurrent topic for researchers and practitioners since its formulation. Hundreds of empirical studies claim to either prove or disprove the EMH by means of a number of heterogeneous methods. Even though the EMH is usually adjusted to a measure of risk, there is a lack of a formal analysis within a multiple-criteria context. In this paper, we propose a extension of the EMH that accommodates the foundations of multiple-criteria decision analysis. To this end, we rely on a family of parametric signed dissimilarity measures to assess multidimensional performance differences. Since normalization is a critical step in our approach to a…