Search results for "ExAC"

Reslizumab (RES) in patients (pts) with inadequately controlled asthma and elevated blood eosinophils (EOS): Analysis of two phase 3, placebo-control…

2016

Background: RES reduced exacerbation frequency and improved lung function and asthma control in pts with inadequately controlled asthma and elevated blood EOS in two placebo (PBO)-controlled, phase 3 studies (Castro et al. Lancet Resp Med 2015). Aims/objectives: To determine the efficacy of RES in the subset of pts in these studies meeting the definition of ATS/ERS-defined inadequately controlled asthma. Methods: This was a post-hoc analysis of pooled data from two replicate, 52-week, PBO-controlled studies of RES (3mg/kg IV Q4W) in pts with inadequately controlled asthma and blood EOS ≥400/µL who were using medium-to-high dose inhaled corticosteroids; primary results have been reported. As…

Generalized curved beam on elastic foundation solved by Transfer Matrix Method

2011

A solution of space curved bars with generalized Winkler soil found by means of Transfer Matrix Method is presented. Distributed, concentrated loads and imposed strains are applied to the beam as well as rigid or elastic boundaries are considered at the ends. The proposed approach gives the analytical and numerical exact solution for circular beams and rings, loaded in the plane or perpendicular to it. A well-approximated solution can be found for general space curved bars with complex geometry. Elastic foundation is characterized by six parameters of stiffness in different directions: three for rectilinear springs and three for rotational springs. The beam has axial, shear, bending and tor…

Search for Magnetic Monopoles and Stable High-Electric-Charge Objects in 13 Tev Proton-Proton Collisions with the ATLAS Detector

2020

We thank CERN for the very successful operation of the LHC, aswell as the support staff fromour institutionswithout whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; FWF, BMWFW, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq, FAPESP, Brazil; NSERC, CFI, NRC, Canada; CERN; CONICYT, Chile; CAS, NSFC, MOST, China; COLCIENCIAS, Colombia; VSC CR, MSMT CR, MPO CR, Czech Republic; DNSRC, DNRF, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; MPG, HGF, BMBF, Germany; GSRT, Greece; RGC, Hong Kong SAR, Hong Kong China; Benoziyo Center, ISF, Israel; INFN, Italy; JSPS, MEXT, Japan; JINR; CNRST, Morocco; NWO, Nether…

A posteriori error identities for nonlinear variational problems

2015

A posteriori error estimation methods are usually developed in the context of upper and lower bounds of errors. In this paper, we are concerned with a posteriori analysis in terms of identities, i.e., we deduce error relations, which holds as equalities. We discuss a general form of error identities for a wide class of convex variational problems. The left hand sides of these identities can be considered as certain measures of errors (expressed in terms of primal/dual solutions and respective approximations) while the right hand sides contain only known approximations. Finally, we consider several examples and show that in some simple cases these identities lead to generalized forms of the …

IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation

2017

Alterations of the airway microbiome is often associated with pulmonary diseases. For example, detection of the bacterial pathogen Moraxella catarrhalis in the upper airways is linked with an increased risk to develop or exacerbate asthma. However, the mechanisms by which M. cattarhalis augments allergic airway inflammation (AAI) remains unclear. We here characterized the cellular and soluble mediators of M. catarrhalis triggered excacerbation of AAI in wt and IL-17 deficient as well as in animals treated with TNF-alpha and IL-6 neutralizing antibodies. We compared the type of inflammatory response in M. catarrhalis infected, HDM-allergic and animals infected with M. catarrhalis at differen…

Exact solutions of the Zakharov equations

2009

Análisis de la cirugía guiada en pacientes rehabilitados mediante implantes en extremos distales libres. Férulas analógicas vs digitales

2022

La cirugía guiada busca trasladar de forma reproducible la planificación de implantes a la boca del paciente. La fabricación digital de la férula mostró mayor exactitud, pero los estudios eran in vitro. Los estudios clínicos sólo estudian una única forma de fabricación de la férula. Los objetivos de la tesis fueron analizar la exactitud en pacientes rehabilitados con implantes dentales mediante cirugía guiada según el tipo de apoyo de la férula mediante metanálisis y metanálisis en red. Además, realizar un estudio clínico, analizando la exactitud según la fabricación de la férula. Como objetivos secundarios, comparar el éxito, la pérdida ósea y las complicaciones de la técnica. Material y m…

Cuatro escáneres digitales intra orales: estudio experimental in vitro de la fiabilidad según resolución y estrategias de escaneo en preparaciones de…

2018

Actualmente, la fidelidad de los escáneres intraorales ha sido analizada para su uso en impresiones de un arco dental completo, pero debido a que estas impresiones muestran desviaciones generales más altas que las impresiones locales, es de interés saber si esta fidelidad aumenta analizando piezas unitarias dentro de impresiones largas. Según la ADA (Asociación dental Americana) el ajuste aceptado en la clínica de una restauración indirecta es de 120 micras, asegurando así la supervivencia a largo plazo de la restauración. Se propone aislar digitalmente las piezas, previamente talladas, del arco dental para analizarlas unitariamente y determinar la fidelidad local de cada una. Además, deter…

Exhaled metabolite patterns to identify recent asthma exacerbations

2021

Asthma is a chronic respiratory disease that can lead to exacerbations, defined as acute episodes of worsening respiratory symptoms and lung function. Predicting the occurrence of these exacerbations is an important goal in asthma management. The measurement of exhaled breath by electronic nose (eNose) may allow for the monitoring of clinically unstable asthma and exacerbations. However, data on its ability to perform this is lacking. We aimed to evaluate whether eNose could identify patients that recently had asthma exacerbations. We performed a cross-sectional study, measuring exhaled breath using the SpiroNose in adults with a physician-reported diagnosis of asthma. Patients were randoml…

Cosmological hydrodynamical simulations of galaxy clusters: X-ray scaling relations and their evolution

2018

We analyse cosmological hydrodynamical simulations of galaxy clusters to study the X-ray scaling relations between total masses and observable quantities such as X-ray luminosity, gas mass, X-ray temperature, and $Y_{X}$. Three sets of simulations are performed with an improved version of the smoothed particle hydrodynamics GADGET-3 code. These consider the following: non-radiative gas, star formation and stellar feedback, and the addition of feedback by active galactic nuclei (AGN). We select clusters with $M_{500} > 10^{14} M_{\odot} E(z)^{-1}$, mimicking the typical selection of Sunyaev-Zeldovich samples. This permits to have a mass range large enough to enable robust fitting of the r…