Search results for "ExAC"
showing 10 items of 1440 documents
Metabolism of chlorobenzene and hexachlorobenzene by the zebra fish, Brachydanio rerio.
1989
It is now becoming evident that in many cases metabolites have a greater toxic potential than the parent xenobiotic exposed. For this reason, the knowledge of biotransformation pathways of xenobiotics plays a substantial role in environmental monitoring programs. The zebra fish (Brachydanio rerio, Hamilton-Buchanan) has received increased attention as a model species for freshwater fish in environmental surveillance programs to evaluate potential health and impacts of anthropogenic chemicals. The metabolism of phenol and various substituted phenols in zebra fish has recently been studied. The purpose of the present study was to examine the metabolism of chlorobenzene and hexachlorobenzene (…
Repetitive use of LEvosimendan in Ambulatory Heart Failure patients (LEIA-HF) - The rationale and study design
2022
Abstract Purpose Clinical practice forces the necessity to conduct a clinical trial concerning the group of outpatients with chronically advanced heart failure in III or IV NYHA functional class, frequently requiring hospitalizations due to HF exacerbation, and often left without any additional therapeutic option. The current trial aims to determine the efficacy and safety of repeated levosimendan infusions in the group of severe outpatients with reduced ejection fraction (HFrEF). Material and methods LEIA-HF (LEvosimendan In Ambulatory Heart Failure Patients) is a multicentre, randomized, double-blind, placebo-controlled, phase 4 clinical trial to determine whether the repetitive use of le…
Dimension bounds in monotonicity methods for the Helmholtz equation
2019
The article [B. Harrach, V. Pohjola, and M. Salo, Anal. PDE] established a monotonicity inequality for the Helmholtz equation and presented applications to shape detection and local uniqueness in inverse boundary problems. The monotonicity inequality states that if two scattering coefficients satisfy $q_1 \leq q_2$, then the corresponding Neumann-to-Dirichlet operators satisfy $\Lambda(q_1) \leq \Lambda(q_2)$ up to a finite-dimensional subspace. Here we improve the bounds for the dimension of this space. In particular, if $q_1$ and $q_2$ have the same number of positive Neumann eigenvalues, then the finite-dimensional space is trivial. peerReviewed
Cyanide binding and heme cavity conformational transitions in **Drosophila melanogaster** hexacoordinate hemoglobin
2006
The reason for the presence of hemoglobin-like molecules in insects, such as Drosophila melanogaster, that live in fully aerobic environments has yet to be determined. Heme endogenous hexacoordination (where HisE7 and HisF8 axial ligands to the heme Fe atom are both provided by the protein) is a recently discovered mechanism proposed to modulate O-2 affinity in hemoglobins from different species. Previous results have shown that D. melanogaster hemoglobin 1 (product of the glob1 gene) displays heme endogenous hexacoordination in both the ferrous and ferric states. Here we present kinetic data characterizing the exogenous cyanide ligand binding process, and the three-dimensional structure (a…
Acanthocephalans from Marine Fishes from Patagonia, Argentina
2019
In this study, 542 individual fish from 20 species from the Patagonian continental shelf of Argentina were examined for acanthocephalans. A total of 1,547 acanthocephalans belonging to 5 species were collected from 18 species of fish. Adult forms were represented by 2 species: Aspersentis johni (Baylis, 1929) (Heteracanthocephalidae) from longtail southern cod, Patagonotothen ramsayi (Regan) (new host record), and Breizacanthus aznari Herna´ndez-Orts, Alama-Bermejo, Crespo, Garcı´a, Raga and Montero, 2012 (Arhythmacanthidae) from raneya, Raneya brasiliensis (Kaup). Immature worms of B. aznari were also collected from the intestine of pink cusk-eel, Genypterus blacodes (Forster) (new host re…
Immobilization of Hexacyanoferrate (III) for a Flow Injection-Spectrophotometric Determination of Promazine
1993
Abstract An automated flow injection method for the determination of promazine is described. The method is based on the oxidation of promazine by hexacyanoferrate (III) and spectrophotometric monitorization of oxidized drug. The chemical and FIA variables were optimized. The calibration graph was linear over the concentration range 2,5–25 ppm of promazine hydrochloride. Some interfering substances were also investigated. The method was applied for the determination of promazine in pharmaceutical formulations.
CCDC 2000868: Experimental Crystal Structure Determination
2020
Related Article: Marcel Dillenburger, Zijie Qiu, Cheng-Wei Ju, Beate Müller, Svenja Morsbach, Dieter Schollmeyer, Akimitsu Narita, Klaus Müllen|2020|J.Am.Chem.Soc.|142|12916|doi:10.1021/jacs.0c04956
Mo(CO)6 dissociation on Cu(111) stimulated by a Scanning Tunneling Microscope
2013
Abstract The surface of Cu(111) was exposed to molybdenum hexacarbonyl Mo(CO)6 with monolayer coverage at temperature 160 K and studied by a Scanning Tunneling Microscope. The monolayer structure has a hexagonal arrangement and forms a (√7 × √7) R19 superlattice on the copper (111) plane. Upon repeated scanning the monolayer is transformed into a (1 × 2) superstructure with 3-fold oriented domains. The domains of (1 × 2) superstructure can change orientation under scanning according to 3-fold surface symmetry. From analysis of the domain mobility, it follows that CO groups of carbonyl fragments are organized in the (1 × 2) superstructure conditioning the domain reorientation. The observed s…
Study of single top production at high energy electron positron colliders
2014
The effect of single top production on the study of top quark pair production in future high energy electron--positron colliders is evaluated. The rate of the single top quark production process is sizeable throughout a large range of center-of-mass energies and cannot easily be distinguished from the dominant pair production process. We discuss the impact on the top quark mass extraction from a scan through the pair production threshold and the determination of top quark form factors in the continuum. These results advocate for the exploration of the inclusive $e^+e^-\rightarrow W^+bW^-\bar{b}$ process, that includes both top quark pair and single top quark production.
The dyon charge in noncommutative gauge theories
2007
We present an explicit classical dyon solution for the noncommutative version of the Yang-Mills-Higgs model (in the Prasad-Sommerfield limit) with a tehta term. We show that the relation between classical electric and magnetic charges also holds in noncommutative space. Extending the Noether approach to the case of a noncommutative gauge theory, we analyze the effect of CP violation at the quantum level, induced both by the theta term and by noncommutativity and we prove that the Witten effect formula for the dyon charge remains the same as in ordinary space.