Search results for "Exchange"
showing 10 items of 2035 documents
Prediction of Highly Non-stationary Time Series Using Higher-Order Neural Units
2017
Adaptive predictive models can use conventional and nonconventional neural networks for highly non-stationary time series prediction. However, conventional neural networks present a series of known drawbacks. This paper presents a brief discussion about this concern as well as how the basis of higher-order neural units can overcome some of them; it also describes a sliding window technique alongside the batch optimization technique for capturing the dynamics of non-stationary time series over a Quadratic Neural Unit, a special case of higher-order neural units. Finally, an experimental analysis is presented to demonstrate the effectiveness of the proposed approach.
Ensuring the Consistency of Biosimilars
2017
Background: Biological products are subject to constant reappraisal by regulatory agencies and pharmaceutical companies once they have entered the market, since every improvement in their manufacturing process has the potential to alter the basic properties of these molecules. Methods: Narrative review focusing on scientific literature as well as legal documents from regulatory agencies. Results: Evaluating the impact of each manufacturing change of these drugs requires rigorous analyses in proportion to the anticipated risk of inducing more or less molecular micro-heterogenicity. There are currently more than 30 biosimilars of TNF-alpha blockers at different stages of testing, each with a …
Statistical identification with hidden Markov models of large order splitting strategies in an equity market
2010
Large trades in a financial market are usually split into smaller parts and traded incrementally over extended periods of time. We address these large trades as hidden orders. In order to identify and characterize hidden orders we fit hidden Markov models to the time series of the sign of the tick by tick inventory variation of market members of the Spanish Stock Exchange. Our methodology probabilistically detects trading sequences, which are characterized by a net majority of buy or sell transactions. We interpret these patches of sequential buying or selling transactions as proxies of the traded hidden orders. We find that the time, volume and number of transactions size distributions of …
Proof-of-Principle Direct Measurement of Particle Statistical Phase
2022
The symmetrization postulate in quantum mechanics is formally reflected in the appearance of an exchange phase governing the symmetry of identical-particle global states under particle swapping. Many indirect measurements of this fundamental phase have been reported thus far, but a direct observation has been achieved only recently for photons. Here, we propose a general scheme capable of directly measuring the exchange phase of any type of particle (bosons, fermions, or anyons), exploiting the operational framework of spatially localized operations and classical communication. We experimentally implement it on an all-optical platform, providing a proof of principle for different simulated …
Charmed and strange baryon resonances with heavy-quark spin symmetry
2012
We study charmed and strange baryon resonances that are generated dynamically by a unitary baryon-meson coupled-channel model which incorporates heavy-quark spin symmetry. This is accomplished by extending the SU(3) Weinberg-Tomozawa chiral Lagrangian to SU(8) spin-flavor symmetry plus a suitable symmetry breaking. The model produces resonances with negative parity from s-wave interaction of pseudoscalar and vector mesons with $1/2^+$ and $3/2^+$ baryons. Resonances in all the isospin, spin, and strange sectors with one, two, and three charm units are studied. Our results are compared with experimental data from several facilities, such as the CLEO, Belle or BaBar Collaborations, as well as…
An Experimental and Computational Study on the Effect of Al(OiPr)3 on Atom-Transfer Radical Polymerization and on the Catalyst-Dormant Chain Halogen …
2005
International audience; Compound Al(OiPr)3 is shown to catalyze the halide-exchange process leading from [Mo(Cp)Cl2(iPrN=CH-CH=NiPr)] and CH3CH(X)COOEt (X=Br, I) to the mixed-halide complexes [Mo(Cp)ClX(iPrN=CH-CH=NiPr)]. On the other hand, no significant acceleration is observed for the related exchange between [MoX3(PMe3)3] (X=Cl, I) and PhCH(Br)CH3, by analogy to a previous report dealing with the RuII complex [RuCl2(PPh3)3]. A DFT computation study, carried out on the model complexes [Mo(Cp)Cl2(PH3)2], [MoCl3(PH3)3], and [RuCl2(PH3)3], and on the model initiators CH3CH(Cl)COOCH3, CH3Cl, and CH3Br, reveals that the 16-electron RuII complex is able to coordinate the organic halide RX in a…
Isotope dilution inductively coupled plasma quadrupole mass spectrometry in connection with a chromatographic separation for ultra trace determinatio…
2000
An isotope dilution inductively coupled plasma quadrupole mass spectrometric (ID-ICP-QMS) method was developed for the simultaneous determination of the platinum group elements Pt, Pd, Ru, and Ir in environmental samples. Spike solutions, enriched with the isotopes 194Pt, 108Pd, 99Ru, and 191Ir, were used for the isotope dilution step. Interfering elements were eliminated by chromatographic separation using an anion-exchange resin. Samples were dissolved with aqua regia in a high pressure asher. Additional dissolution of possible silicate portions by hydrofluoric acid was usually not necessary. Detection limits of 0.15 ng x g(-1), 0.075 ng x g(-1), and 0.015 ng x g(-1) were achieved for Pt,…
Ranking World Tourism Competitiveness: A Comparison of Two Composite Indicators
2021
Assessing travel and tourism competitiveness (T&TC) is becoming an issue of paramount importance for stakeholders, mainly policymakers and practitioners. The availability of new databases such as the Travel and Tourism Competitiveness Report from the World Economic Forum (WEF) has boosted this interest. This chapter contributes to the current literature in this field with an assessment of the T&TC of 136 world tourist destinations. In doing so, two well-known approaches are employed: Data Envelopment Analysis (DEA) with endogenous common weights, and the Technique for Order of Preference by Similarity to Ideal Solutions (TOPSIS). World tourist destinations are ranked using these approaches,…
Cardiovascular and Autonomic Responses to a Maximal Exercise Test in Elite Youngsters
2017
AbstractTo analyze cardiovascular and autonomic responses in elite youngsters, 13 male cyclists (15.43±0.51 years) performed a graded-test until voluntary exhaustion. Oxygen consumption (VO2), blood lactate (BLa), arterial oxygen saturation (SaO2), respiratory exchange ratio (RER) and rating of perceived exertion (RPE) were collected, while heart rate (HR) was registered for heart rate variability (HRV) analyses, looking for linear and nonlinear comparisons. Cyclists reached maximal exertion [RPE: 19.14±0.94; BLa: 8.92±2.51 mmol.L−1; RER: 1.04±0.03; SaO2: 92.43±2.5%] and high-level performance (4.41±0.46 W·Kg−1; 60.77±6.87 ml·Kg·min−1) once over 95% of age-predicted HRmax. VO2 and RPE incre…
Hydroquinone: O-glucosyltransferase from cultivated Rauvolfia cells: enrichment and partial amino acid sequences.
2000
Plant cell suspension cultures of Rauvolfia are able to produce a high amount of arbutin by glucosylation of exogenously added hydroquinone. A four step purification procedure using anion exchange, hydrophobic interaction, hydroxyapatite-chromatography and chromatofocusing delivered in a yield of 0.5%, an approximately 390 fold enrichment of the involved glucosyltransferase. SDS-PAGE showed a M(r) for the enzyme of 52 kDa. Proteolysis of the pure enzyme with endoproteinase LysC revealed six peptide fragments with 9-23 amino acids which were sequenced. Sequence alignment of the six peptides showed high homologies to glycosyltransferases from other higher plants.