Search results for "Expiration"

Airway Responsiveness to Adenosine 5′-Monophosphate and Exhaled Nitric Oxide Measurements

2003

Objectives To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5′-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well controlled with a moderately high ICS dose. Methods A total of 37 patients with asthma well controlled for at least 3 months by treatment with a moderately high ICS dose (beclomethasone dipropionate, 500 to 1,000 μg or equivalent daily) were included in the study. Patients were treated for a 2-week run-in (baseline) period with their usual dose of ICS. For the next 12 weeks, patients were treated with ICS at half the previous d…

Stellenwert der Spirometertriggerung für die hochauflösende Computertomographie der Lunge in Inspiration und Exspiration

1998

PURPOSE To compare mean lung density (MLD) of paired inspiratory and expiratory thin-section CT scans acquired after patient instruction or using spirometric gating. MATERIALS AND METHODS 21 patients (13 m, 8 f. median age 59 years, two with normal lung function, 15 with obstructive, 4 with restrictive impairment) underwent thin-section CT. Paired inspiratory and expiratory scans were performed in the upper, middle and lower lung fields. They were acquired after automatic patient instruction with constant intervals between instruction and scan. Spirometrically gated scans were acquired within 4 days at 80% and 20% of vital capacity (VC) which has been determined on the CT scanner in supine …

Physico-Chemical Stability of Admixtures of Vinflunine Used in Clinical Practice.

2021

Procedure of administration of vinflunine is complex and consists of an Y-site injection with fluid at different speeds. Dose is diluted with 100 mL of 0.9% sodium chloride or 5% glucose and infused with half of the 500 mL bag of the fluid over 20 min; after that, the remaining fluid is administered at 300 mL/h. In this study, chemical stability and physical compatibility of vinflunine diluted with in 500 mL of both fluids were evaluated to simplify the administration procedure (infusion of mixture on 20 min followed by 250 mL of fluid at 300 mL/h). Physical compatibility and chemical stability were evaluated at two temperatures and protected from and exposed to light. Physical compatibilit…

Association between nasal and bronchial resistance in patients with COPD

2018

Background: During the past decade, various studies have documented the presence of sinonasal inflammation in lower airways diseases. The influence of airways inflammation on nasal airways patency was demonstrated in asthmatic patients; however, such association was not confirmed in patients with COPD. Purpose: The aim of the study was to compare the relationship between nasal resistance and lower airways patency in COPD patients and healthy controls. Material and Methods: 4-Phase-Rhinomanometry and spirometry were performed on COPD patients (n=26) and in the corresponding age control group (n=15). To compare the effective nasal resistance in inspiration, expiration and total breathing (Ref…

Quantification of Lung Volume at Different Tidal Volumes and Positive End-Expiratory Pressures in a Porcine Model by Using Retrospective Respiratory …

2008

PURPOSE: This feasibility study in healthy animals should prove the concept that it is possible to quantitatively assess the effects of different ventilatory settings on the lung parenchyma during ongoing ventilation in respiratory gated 4-dimensional (D)-computed tomography (CT). For this purpose, the influence of different tidal volumes and positive end-expiratory pressure (PEEP) on quantitative assessment of lung volumes (LVs) and lung compartments was analyzed. METHODS: Five anesthetized and ventilated (20 breaths/min, inspiratory/expiratory ratio of 1:2) healthy pigs underwent 16-row multidetector CT with retrospective respiratory gating using a noncontact charge-coupled device camera …

Non-isothermal thermogravimetry as an accelerated tool for the shelf-life prediction of paracetamol formulations

2021

Abstract In this work, non-isothermal thermogravimetric studies have been carried out on several paracetamol formulations with the aim to predict their shelf-lives under variable storage conditions. Specifically, paracetamol tablets of different brands have been investigated allowing to estimate their pharmaceutical quality by considering the specific drug stability. The proposed protocol is based on the kinetic study of thermogravimetric data by the combination of isoconversional procedures (Friedman and Kissinger-Akahira-Sunose (KAS) methods) and “Master plot” analysis. Accordingly, the kinetics of the paracetamol degradation is totally explored in terms of activation energy, pre-exponent…

A device to trigger automatically electrical stimulation at different states of in- or expiration on the background of variable lung inflation in the…

1975

A device is described which permits to obtain a signal at the beginning of in- or expiration respectively. This signal may be used to trigger an electrical stimulator. To permit studies at different states of lung inflation the tracheal cannula is connected to a spirometer circuit. To produce constant positive or negative air pressure this bellows-type spirometer is loaded with exchangeable metal weights. The tracheal pressure is recorded by means of a pressure transducer, the output of which is taken as signal. The device allows accurate compensation of the DC-component of the transducer output resulting from spirometer operation at a maintained positive or negative pressure.

Studies on extemporal drug storage and expiration dates

2007

Clause compromissoire. Expiration du délai de l'arbitrage. Extinction de l'instance. Obligation de constituer un nouveau tribunal arbitral. Incompéte…

1999

International audience; (Cass. 2e civ., 18 févr. 1999, inédit, Igla c/ Sté Soulier et autres)

Increased airway inflammatory cells in endurance athletes: what do they mean?

2003

Background Inflammatory cells are increased in the airways of end urance athletes, but their role in causing exercise-induced respiratory symptoms and bronchoconstriction, or their possible long-term consequences, are uncertain. Aim To put the results of athlete studies in perspective, by analysing the pathogenesis of airway cell changes and their impact on respiratory function. Results Athletes of different endurance sports at rest showed increased airway neutrophils. Elite swimmers and skiers also showed large increases in airway eosinophils and lymphocytes, possibly related to chronic, exercise-related exposure to irritants or cold and dry air, respectively. Post-exercise studies reporte…