Search results for "Export"
showing 10 items of 152 documents
MicroRNAs: Promising New Antiangiogenic Targets in Cancer
2014
[EN] MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very numerous, have been phylogenetically conserved, and involved in biological processes such as development, differentiation, cell proliferation, and apoptosis. MicroRNAs contribute to modulating the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules and so they play a key role in both health and disease. Angiogenesis is the process of new blood vessel formation from preexisting ones, which is particularly relevant to cancer and its progression. Over the last few years, microRNAs have emerged as critical regulat…
La medición de los resultados de la promoción de las exportaciones: dificultad y necesidad
2002
En este artículo se revisa el concepto de promoción de las exportaciones como un conjunto de actividades diseñadas por entidades públicas y privadas con objeto de ayudar a las empresas en su internacionalización. Para saber si estas políticas están ayudando a las empresas a alcanzar sus objetivos internacionales, es necesario llevar a cabo una valoración de los resultados, a pesar de las dificultades que ello supone. Se han realizado algunas experiencias en este ámbito, en otros mercados, que nos pueden servir de referente para una posible aplicación en nuestro entorno. Haydee.Calderon@uv.es; Teresa.Fayos@uv.es
Contenido factorial y comercio España-Mercosur
1999
El presente artículo analiza las características asociadas al comercio España-Mercosur a través de la estimación de sus factores determinantes. Este ejercicio supone la aplicación de diversas técnicas de análisis económico, las cuales se basan en el Teorema de Heckscher y Ohlin. El resultado de la estimación permite evidenciar que la economía española se revela como relativamente abundante en capital humano frente al Mercosur, mientras que el Mercosur se revela como relativamente abundante en capital físico respecto de la economía española lo que supone un resultado del tipo «paradoja de Leontieff». Los resultados obtenidos permiten recomendar la intensificación de las relaciones comerciale…
Bush, camino del Nobel
2003
La corrupción institucionalizada
1998
La industria del cómic en España: radiografía de ¿un mito o una realidad?
2011
In spite of the importance of figures referred to published titles, or number of copies printed, which help to set publishing strategies and to really know the comic situation in Spain, there are no liable data. We are giving in this article, some enlightening data along with some explanations related to the evolution of the market from 2001 to 2009. The different titles are grouped considering the place they come from (Europe, Asia, United States…), along with their format (album, book, magazine, comic-book…). Using all this information, we can deduce evolution lines, tendencies, futures perspectives in an industry that, despite its precariousness, is facing an increasing number of copies …
Nuclear and Cytoplasmic Survivin: Molecular Mechanism, Prognostic, and Therapeutic Potential.
2007
Abstract Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and nuclear protein in cancer patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. Recent evidence shows that the direct interaction of survivin with the nuclear export receptor Crm1 is critically involved in its intracellular localization and cancer-relevant functions. Here, we review our current understanding of the Crm1/survivin interface and discuss its potential prognostic and therapeutic relevance. [Cance…
Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker
2007
Survivin functions as an apoptosis inhibitor and a regulator of cell division in many tumours. The intracellular localization of survivin in tumours has been suggested as a prognostic marker. However, current reports are inconsistent and the underlying molecular mechanisms are not understood. The present study has examined the localization and prognostic value of nuclear and cytoplasmic survivin in the pre-therapeutic biopsies from 71 oral and oropharyngeal squamous carcinoma (OSCC) patients. Statistical analysis indicated that preferential nuclear versus cytoplasmic survivin correlated with favourable versus unfavourable disease outcome. Uni- and multi-variate analysis showed that in contr…
Molecular basis of the functional distinction between Cln1 and Cln2 cyclins
2012
Cln1 and Cln2 are very similar but not identical cyclins. In this work, we tried to describe the molecular basis of the functional distinction between Cln1 and Cln2. We constructed chimeric cyclins containing different fragments of Cln1 and Cln2 and performed several functional analysis that make it possible to distinguish between Cln1 or Cln2. We identified that region between amino acids 225 and 299 of Cln2 is not only necessary but also sufficient to confer Cln2 specific functionality compared with Cln1. We also studied Cln1 and Cln2 subcellular localization identifying additional differences between them. Both cyclins are distributed between the nucleus and the cytoplasm, but Cln1 shows…