Search results for "Eye"
showing 10 items of 2511 documents
Dual-stage and dual-deficit? Word recognition processes during text reading across the reading fluency continuum
2021
AbstractCentral questions in the study of visual word recognition and developmental dyslexia are whether early lexical activation precedes and supports decoding (a dual-stage view) or not (dual-route view), and the locus of deficits in dysfluent reading. The dual-route view predicts early word frequency and length interaction, whereas the dual-stage view predicts word frequency effect to precede the interaction effect. These predictions were tested on eye movements data collected from (n = 152) children aged 9–10 among whom reading dysfluency was overrepresented. In line with the dual-stage view, the results revealed an early word frequency effect in first fixation duration followed by robu…
Sublexical effects on eye movements during repeated reading of words and pseudowords in Finnish
2011
The role of different orthographic units (letters, syllables, words) in reading of orthographically transparent Finnish language was studied by independently manipulating the number of letters (NoL) and syllables (NoS) in words and pseudowords and by recording eye movements during repeated reading aloud of these items. Fluent adult readers showed evidence for using larger orthographic units in (pseudo)word recoding, whereas dysfluent children seem to be stuck in a letter-based decoding strategy, as lexicality and item repetition decreased the NoL effect only among adult readers. The NoS manipulation produced weak repetition effects in both groups. However, dysfluent children showed evidence…
All-trans to 11-cis conversion of endogenous retinoids in nuclear membrane preparations from bovine retinal pigment epithelium
1992
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Intravitreal injection of bevacizumab induces inflammatory alterations in a uveitis experimental model.
2010
PurposeBevacizumab is currently used as an intravitreal agent in the treatment of inflammatory-associated eye diseases. The aim of the current study is to explore the effects of the intravitreal injection of bevacizumab on aqueous humour cytokines and chemokines in an experimental uveitis model.MethodsEndotoxin-induced uveitis was induced in rats by footpad injections. Bevacizumab was administered by intravitreal injection (75 μg in 3–μL samples) and different chemokine and cytokine proteins were quantified in aqueous humor.ResultsIntravitreal administration of bevacizumab led to a several-fold increase of RANTES, MCP-1, and IFN-γ concentrations in aqueous humor of endotoxin-treated rats.Co…
Inducible galectins are expressed in the inflamed pharynx of the ascidian Ciona intestinalis
2011
Although ascidians belong to a key group in chordate phylogenesis, amino acid sequences of Ciona intestinalis galectin-CRDs (CiLgals-a and -b) have been retained too divergent from vertebrate galectins. In the present paper, to contribute in disclosing Bi-CRD galectin evolution a novel attempt was carried out on CiLgals-a and -b CRDs phylogenetic analysis, and their involvement in ascidian inflammatory responses was shown. CiLgals resulted aligned with Bi-CRD galectins from vertebrates (Xenopus tropicalis, Gallus gallus, Mus musculus, Homo sapiens), cephalochordates (Branchiostoma floridae), echinoderms (Strongylocentrotus purpuratus) and a mono-CRD galectin from the ascidian Clavelina pict…
Congenital Hepatic Fibrosis
2005
The disease presentation of autosomal recessive polycystic kidney disease (OMIM #263200, ARPKD) is highly variable and includes polycystic kidneys, pulmonary hypoplasia, and congenital hepatic fibrosis. The authors report an unusual case of ARPKD presenting with hepatosplenomegaly and cytopenia mimicking acute leukemia.
Adolescent Depressive Symptoms and Breakup Distress During Early Emerging Adulthood
2017
Breakups are a normative and frequent part of the romantic experience. In this longitudinal study, we followed 144 adolescents (mean age = 16.57) for a period of 4 years and examined the extent to which level of depressive symptoms predicts the intensity of breakup distress during emerging adulthood and, further, the extent to which breakup distress reported during emerging adulthood is associated with the quality of a current romantic relationship. The findings suggest that higher levels of depressive symptoms during adolescence can lead to more difficulty in recovering from breakup in early emerging adulthood. In addition, experiencing greater breakup distress during emerging adulthood w…
Analysis of cell-free human alpha1 integrin with a monoclonal antibody to the I-domain: detection in ocular fluid and function as an adhesion substra…
2002
The alpha1 beta1 integrin, an inserted (1) domain containing collagen receptor, is expressed in the cell surface membrane of normal and malignant cells, and may play a role in their migration through tissues or in metastatic spread. Here we report that a functional anti-human alpha1beta1 integrin monoclonal antibody (mAb) (1B3.1) directly and specifically binds plastic bound recombinant human alpha1 I-domain protein containing the collagen binding site. Detection was diminished by acidification of the I-domain protein but was enhanced by increasing concentrations of Mg2+ cation. Furthermore, we detected binding of the mAb to proteins from the ocular fluids of 6 patients, with the highest co…
Biochemical and Immunological implications of Lutein and Zeaxanthin
2021
Throughout history, nature has been acknowledged for being a primordial source of various bioactive molecules in which human macular carotenoids are gaining significant attention. Among 750 natural carotenoids, lutein, zeaxanthin and their oxidative metabolites are selectively accumulated in the macular region of living beings. Due to their vast applications in food, feed, pharmaceutical and nutraceuticals industries, the global market of lutein and zeaxanthin is continuously expanding but chemical synthesis, extraction and purification of these compounds from their natural repertoire e.g., plants, is somewhat costly and technically challenging. In this regard microbial as well as microalga…
LED Based Dual Wavelength Heterochromatic Flicker Method for Separate Evaluation of Lutein and Zeaxanthin in Retina
2013
The decrease of density and consequentially optical density of macular pigment serves as a diagnostic mean for a number of ophthalmological pathologies, particularly as a risk factor for age related macular degeneration. Macular pigment absorbs light in short wavelength blue spectral range. Thus the optical density of macular pigment can be detected by various optical – both objective and subjective psychophysical techniques. Latter techniques use eye and brain visual pathways as spectral sensitive optical detector and decision maker, and exploit perception facility to process information flow in a unique manner to create various perception illusions. The psychophysical methods of detection…