Search results for "F.1.2"

Synthesis and antiproliferative activities of two new analogs of tetrazepinones

Based on the encouraging results, we report the multistep synthesis and the biologicalo results of two new analogs of tetrazepinones: the 3,5-dimethyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one and the 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl-5,6-dihydropyrazo1o[3-4-f]1,2,35)tetrazepin-4(3H)-one. Both compounds showed a pro-apoptotic activity against HL60 and K562 resistant cell lines. Flow cytometry studies carried out 0n K562 cells allowed to establish that the methyl derivative induces G0-G1, phase arrest followed by apoptosis, whereas the chloroethyl derivative is a not phase-specific agent.

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain

2008

AbstractIFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex. In order to evaluate the biological role of the Ift172 gene, we generated a loss-of-function mutation in the mouse. The resulting Slb mutant embryos die between E12.5 and 13.0, and exhibit severe cranio-facial malformations, failure to close the cranial neural tube, holoprosencephaly, heart edema and extensive hemorrhages. Cilia outgrowth in cells of the neuroepithelium is initiated but the axonemes are severely truncated and do not contain visible microtubules. Morphological and molecular analyses revealed a global brain-patterning defect along the dorsal–…

On Physical Problems that are Slightly More Difficult than QMA

2013

We study the complexity of computational problems from quantum physics. Typically, they are studied using the complexity class QMA (quantum counterpart of NP) but some natural computational problems appear to be slightly harder than QMA. We introduce new complexity classes consisting of problems that are solvable with a small number of queries to a QMA oracle and use these complexity classes to quantify the complexity of several natural computational problems (for example, the complexity of estimating the spectral gap of a Hamiltonian).

Topological properties of cellular automata on trees

2012

We prove that there do not exist positively expansive cellular automata defined on the full k-ary tree shift (for k>=2). Moreover, we investigate some topological properties of these automata and their relationships, namely permutivity, surjectivity, preinjectivity, right-closingness and openness.

La tradición clásica como referencia de vanguardia: la Antigüedad griega y romana en la obra del pintor Gregorio Prieto (1897-1992)

2019

This article analyses the impact of classical tradition on the artistic production of Gregorio Prieto (1897-1992), painter par excellence of the Generation of 1927. It will be discovered how this influence, far from becoming a conservative reference, would constitute an incentive for his entailment with the avant-garde, especially with surrealism. Although the classic trace is found with more intensity in the creations produced during his Roman years, between 1928 and 1929, when he also made important trips to Sicily and Greece, Greece and Rome would nevertheless continue to be constitutive of his aesthetic experience throughout his later and extensive career.

Niccolò Palmeri

2014

Profilo biografico dell'economista, storico e politico siciliano (1788-1837) pubblicato sul Dizionario Biografico degli Italiani A biographical sketch of the Sicilian political economist and historian (1788-1837) in the Dizionario Biografico degli Italiani

THE AMBIGUITIES OF « GRANTED CONSTITUTIONALISM » : A TRANSATLANTIC DEBATE (II)

2017

After France, and before Brazil, the second article concerns Portugal. The portuguese legal framework was appropriate to stem the birth of the constituent power. Reconstructed on the basis of an apocryphal transcription of its founding pact, the Cortes of Lamego of 1143, the portuguese public law benefited on top of a written document born in the XVth century, the Ordenações. This double peculiarity, making "iberian liberties" a model of the ancient constitutionalism, explains the reverential respect for these medieval borders and the hatred following Dom Pedro's granting in 1826. In these conditions, and in spite of the program followed by a "granting power" which refuses to define itself …

One-counter verifiers for decidable languages

2012

Condon and Lipton (FOCS 1989) showed that the class of languages having a space-bounded interactive proof system (IPS) is a proper subset of decidable languages, where the verifier is a probabilistic Turing machine. In this paper, we show that if we use architecturally restricted verifiers instead of restricting the working memory, i.e. replacing the working tape(s) with a single counter, we can define some IPS's for each decidable language. Such verifiers are called two-way probabilistic one-counter automata (2pca's). Then, we show that by adding a fixed-size quantum memory to a 2pca, called a two-way one-counter automaton with quantum and classical states (2qcca), the protocol can be spac…

Cádiz en Charcas: conjeturas e indicios

2012

Este es un artículo de historia constitucional. Se centra en la relación entre la Constitución española de 1812 y la Constitución boliviana de 1826. Su conclusión principal niega la idea de que, por el solo hecho de que ambas fueron cartas liberales contemporáneas entre sí escritas en la misma lengua, la primera Constitución haya influenciado en la segunda. Al contrario, toma a las semejanzas de redacción como un mero mecanismo de auxilio técnico, pero no por una fuente de influencia. Y, no las califica así, porque la influencia supone una relación de autoridad moralmente justificada, lo que, precisamente, estaba ausente entre el poder metropolitano y sus colonias. Una serie de documentos h…

LES ÉQUIVOQUES DU « CONSTITUTIONNALISME OCTROYÉ » : UN DÉBAT TRANSATLANTIQUE (I)

2015

In Portugal and in its former colonies, the expression "constitucionalismo outorgado » is part of the constitutional vocabulary since the granting of the Charter of 1826. The French inspiration is obvious ; however, no equivalent expression exists in France. This curiosity leads to measure all the ambiguity of the concept of "granted constitutionalism", an improbable oxymoron according to the president of the Portuguese Republic, Teófilo Braga. Is it about a simple political and linguistic claim, a temporary compromise at the end of a frustrated Revolution? Or does it translate a deeper program, to reconcile both sides of the constitutionalism, ancient and modern ?