Search results for "F2"

Orientation theory in arithmetic geometry

2016

This work is devoted to study orientation theory in arithmetic geometric within the motivic homotopy theory of Morel and Voevodsky. The main tool is a formulation of the absolute purity property for an \emph{arithmetic cohomology theory}, either represented by a cartesian section of the stable homotopy category or satisfying suitable axioms. We give many examples, formulate conjectures and prove a useful property of analytical invariance. Within this axiomatic, we thoroughly develop the theory of characteristic and fundamental classes, Gysin and residue morphisms. This is used to prove Riemann-Roch formulas, in Grothendieck style for arbitrary natural transformations of cohomologies, and a …

Effects of nutraceuticals of Mediterranean diet on aging and longevity

2020

Abstract Among the many existing dietary interventions, Mediterranean diet has received much attention because of its beneficial influence on healthy aging and longevity. Mediterranean dietary pattern, characterized by low glycemic index and low-animal protein intake, is rich in nutraceuticals and functional foods, and bioactive compounds able to reduce the signaling of molecular pathways, such as nutrient-sensing ones, affecting aging process. Therefore a close adherence to a Mediterranean-style diet allows avoiding cardiovascular disorders and other age-related diseases, and it is responsible for the high rate of long-living individuals scattered throughout the Mediterranean basin. For th…

Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER⁺ breast tumors.

2013

MEF2s transcription factors and class IIa HDACs compose a fundamental axis for several differentiation pathways. Functional relationships between this axis and cancer are largely unexplored. We have found that class IIa HDACs are heterogeneously expressed and display redundant activities in breast cancer cells. Applying gene set enrichment analysis to compare the expression profile of a list of putative MEF2 target genes, we have discovered a correlation between the down-regulation of the MEF2 signature and the aggressiveness of ER(+) breast tumors. Kaplan-Meier analysis in ER(+) breast tumors evidenced an association between increased class IIa HDACs expression and reduced survival. The im…

Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.

2013

Neural activity has profound effects on the development of dendritic structure. Mechanisms that link neural activity to nuclear gene expression include activity-regulated factors, such as CREB, Crest or Mef2, as well as activity-regulated immediate-early genes, such as fos and jun. This study investigates the role of the transcriptional regulator AP-1, a Fos-Jun heterodimer, in activity-dependent dendritic structure development. We combine genetic manipulation, imaging and quantitative dendritic architecture analysis in a Drosophila single neuron model, the individually identified motoneuron MN5. First, Dα7 nicotinic acetylcholine receptors (nAChRs) and AP-1 are required for normal MN5 dend…

Shedding of membrane vesicles containing HSP70 and FGF-2 from A6 stem cells.

2007

Mesoangioblasti di topo producono e rilasciano nello spazio extracellulare vescicole di membrana contenenti MMP9 e FGF2 in forma attiva

2009

Broadening the phenotypic spectrum and physiological insights related toEIF2S3variants

2021

Mental deficiency, epilepsy, hypogonadism, microcephaly and obesity (MEHMO) syndrome is a severe X-linked syndrome caused by pathogenic variants in EIF2S3. The gene encodes the γ subunit of the eukaryotic translation initiation factor-2, eIF2, essential for protein translation. A recurrent frameshift variant is described in severely affected patients while missense variants usually cause a moderate phenotype. We identified a novel missense variant (c.433A>G, p.(Met145Val)) in EIF2S3 in a mildly affected patient. Studies on zebrafish confirm the pathogenicity of this novel variant and three previously published missense variants. CRISPR/Cas9 knockout of eif2s3 in zebrafish embryos recapitula…

Offshoring along the production chain

2009

Recent contributions on offshoring often assume that firms can freely split their production process into separate steps which can be ranked according to the cost savings from producing abroad. We replace this assumption by the notion of a technologically determined sequence of production steps. In our model, cost savings from offshoring fluctuate along the production chain, and moving unfinished goods across borders causes transport costs. We show that, in such a setting, firms may refrain from offshoring even if relocating individual steps would be advantageous in terms of offshoring costs, or they may offshore (almost) the entire production chain to save transport costs. Small variations…

Highly luminescent perovskite–aluminum oxide composites

2015

In this communication we report on the preparation of CH3NH3PbBr3 perovskite/Al2O3 nanoparticle composites in a thin film configuration and demonstrate their high photoluminescence quantum yield. The composite material is solution-processed at low temperature, using stable alumina nanoparticle dispersions. There is a large influence of the alumina nanoparticle concentration on the perovskite morphology and on its photoluminescence.

Headquarters’ Control Capacity and the Choice of R&D Organizational Forms Abroad

2013

International audience; Recently, regarding globalization, the decentralization of R&D activities abroad by multinational companies (MNCs) has become important in developed countries. However, academic research has not given this topic sufficient attention. This paper explains how the efficiency of control and incentive mechanisms may affect the choice of organizational forms by MNCs that decentralize their R&D activities abroad. We identify five main organizational forms: wholly owned green-field subsidiary, wholly owned acquired subsidiary, joint venture, cross-licensing agreements, and unilateral licensing agreements. A questionnaire addressed to the R&D managers of American and European…