Search results for "F2"
showing 10 items of 316 documents
Incorporación de valor social a la contratación pública en España: Situación y perspectivas
2016
La consideración del valor social en las transacciones con capital público debería ser un garante de mejora en las sociedades actuales. La inclusión de un reconocimiento e impulso de iniciativas de tipo social o medioambiental, por parte de las entidades públicas, en el momento de llevar a cabo concursos, compras o concesión de subvenciones, podría generar un incremento de la calidad de vida de los ciudadanos, objetivo que, sin duda, debería perseguir cualquier Administración Pública. En el presente artículo se revisa de forma comprensiva la situación de las administraciones (local, autonómica y nacional) en España, a la luz de los recientes cambios en la legislación comunitaria sobre contr…
H2O, H2, HF, F2 and F2O nuclear magnetic shielding constants and indirect nuclear spin–spin coupling constants (SSCCs) in the BHandH/pcJ‐n and BHandH…
2009
Good performance of segmented contracted basis sets XZP, where X = D, T, Q and 5, for obtaining H2O, H2, HF, F2 and F2O nuclear isotropic shielding constants in the BHandH Kohn–Sham basis set limit was shown. The results of two‐ and three‐parameter complete basis set limit extrapolation schemes were compared with experimental results, earlier literature data and benchmark ab initio results. Similar convergence patterns of shieldings obtained from calculations using general purpose XZP basis sets and from polarization‐consistent basis sets pcS‐n and pcJ‐n, where n = 0, 1, 2, 3 and 4, designed to accurately predict magnetic properties were observed. On the contrary, the SSCCs were more sensit…
Rôle des protéines de choc thermique dans la régulation du facteur de transcription HIF
2011
Both HIF1α and HIF2α proteins are highly involved in the development of pathologies, such as cancers, which are prime public health issues. These proteins are primarily controlled at the protein level by ubiquitin-dependant degradation, and regulate numerous cellular processes which are likely to favor the development of these diseases. A recent issue in therapeutic research is to identify partners that might regulate the expression and the activity of the HIFα proteins, with the aim to elaborate targeted therapies. Heat shock proteins (HSPs) form a family of proteins whose main function is to regulate protein homeostasis in cells, which they achieve through interaction with the ubiquitin-p…
Activadores del factor de transcripción NRF2 (factor nuclear eritroide 2) en el tratamiento de la Enfermedad Pulmonar Obstructiva Crónica
2022
La Enfermedad Pulmonar Obstructiva Crónica (EPOC) es una enfermedad respiratoria caracterizada por una disminución progresiva e irreversible de la función pulmonar producto de una respuesta inflamatoria crónica de los pulmones a partículas y gases nocivos presente en el ambiente, principalmente del humo de tabaco. El incremento prolongado del estrés oxidativo es un factor principal en la potenciación de la inflamación en EPOC. El factor nuclear eritroide 2 (NRF2) es fundamental en la citoprotección frente al estrés oxidativo al inducir la expresión de enzimas y proteínas antioxidantes y se ha visto implicado en el desarrollo de la enfermedad, por lo que puede representar una diana terapéuti…
Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe.
2014
In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA analogue element called the HomolD box. The HomolD-binding protein Rrn7 forms a complex with the RNA polymerase II machinery. Despite the importance of ribosome biogenesis to cell survival, the mechanisms involved in the regulation of transcription of eukaryotic RPGs are unknown. In this study, we identified Rrn7 as a new substrate of the pleiotropic casein kinase 2 (CK2), which is a regulator of basal transcription. Recombinant Rrn7 from S. pombe, which is often used as a model organism for studying eukaryotic transcription, interacted with CK2 in vitro and in vivo. Furthermore, CK2-mediated phosphorylation…
Modulació de l'artritis gotosa per dues molècules inhibidores de la caspasa-1
2020
L’artritis gotosa es una de les malalties articulars més freqüents d’artritis inflamatòria. Es produeix per la deposició d’urat monosòdic (MSU) en les articulacions, donant lloc a episodis aguts d’inflamació, que poden ser persistents i arribar a cronificar-se. La fagocitosi dels cristalls d’MSU pels neutròfils i macròfags genera la producció de ROS i l’activació de l’NFkappaB, alliberant citocines i activant l’NLRP3. Aquest inflamasoma indueix l’activació de la caspasa1 i la consegüent producció de les formes actives IL1beta i IL18. Les calcones són un grup de la família dels flavonoides, que han demostrat propietats antiinflamatòries i antiartrítiques, actuant sobre diverses dianes terapè…
Ethanol promotes survival and tumor progression of colon cancer cells
2018
In the Western Countries, colon cancer is the third tumor for aggressiveness and incidence after lung and breast/prostate cancer. Different risk factors concur to the development of colon cancer, including genetic factors, inflammation, intestinal microflora composition, as well as lifestyle. Epidemiologic studies correlating alcohol consumption and assert that the risks are 5-fold higher among drinkers compared to nondrinkers. However, the exact mechanisms correlating heavy alcohol drinking and colon cancer are not completely elucidated yet. To shed light on the biochemical mechanisms through which alcohol favors colon cancer progression, we evaluated the effect of high doses of ethanol (1…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
Константин Великий и св. Елена на фресках Яна Кубена в Воздвиженском костеле в Бжеге
2020
The paper introduces the splendid representations of Emperor Constantine the Great and Saint Helena in Jan Kuben’s frescos in the church under invocation of the Triumph of the Cross in Brzeg. They testify strongly of the incessant presence of the creative reflection over the Christian ancient times in the area of Opole Silesia in the period of the Catholic reform in the 18th century. Kuben’s trompe-l’oeil constitutes a wonderful combination of deeply experienced Catholic spirituality with the genius of the artist – a visionary.
KEYNES’S EUROPEANISM AS SHOWN IN “THE ECONOMIC CONSEQUENCES OF THE PEACE”
2012
European integration and enlargement, in the context of decreasing support of European country nationals, needs great men and great ideas standing with. J.M.Keynes proves in his book”The Economic Consequences of the Peace” that there is no other way for Europe than acts together. His economic reasons for which European countries “throb together” are presented here and supported with data. This article, with a historical approach, brings another important and strong view on the side of Europeanism.