Search results for "F2"
showing 10 items of 316 documents
EZH2 mutations are frequent and represent an early event in follicular lymphoma
2013
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations were detected at 3 recurrent mutation hot spots (Y646, A682, and A692) in 27% of FL cases with variant allele frequencies (VAF) ranging from 2% to 61%. By comparing VAF of EZH2 with other mutation targets (CREBBP, MLL2, TNFRSF14, and MEF2B), we were able to distinguish patients harbori…
Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model
2019
AbstractSeveral studies have suggested a possible etiological association between ovarian endometriosis and ovarian cancer. Evidence has shown that KIF20A overexpression might confer a malignant phenotype to ovarian tumors by promoting proliferation and inhibiting apoptosis. However, no data about the role of KIF20A in endometriosis have been described. In this study, the human endometrium (n = 4) was transfected by mCherry adenovirus and intraperitoneally implanted in mice. Subsequently, mice were divided in three groups (n = 8/group) that were treated with Vehicle, BKS0349 (KIF20A-antagonist) or cabergoline (dopamine receptor agonist) for 21 days. mCherry-labeled endometriotic lesions wer…
Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells E…
2022
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber’s hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone’s cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions …
BRAIN DRAIN MIGRATION TYPE. WHAT CAUSES BRAIN DRAIN PHENOMENON?
2015
The phenomenon of migration of intellectuals, also known as "brain drain", we mean that constant transfer of highly qualified persons, especially in generally into less developed countries, to those states that have a developed economy. Most often, aspects of the social environment of home country, are the triggering factor in the migration decision intellectuals. Reducing the negative impact of brain drain can be achieved through the transfer of "know-how" through collaboration between intellectuals in the Diaspora with those of the country of origin in some projects.
Are Energy Market Integrations a Green Light for FDI?
2015
This paper studies the effect of energy market integration (EMI) on foreign direct investment (FDI). EMIs diminish energy uncertainty and price volatility in the host country and affect FDI through two channels: first, by harmonizing energy prices and, second, by reducing price dispersion. FDI may, as a result, increase both within and outside the EMI area, through energy stability mechanisms and price mechanisms, respectively. An empirical application on a global dataset including bilateral FDI data, during 2003-2012, using the gravity equation, shows that the integration of Portugal and Spain's electricity market in 2007 increased the amount of FDI's participants. Additionally, a positive…
Gouvernance contractuelle et cognitive des alliances internationales en R&D
2009
Notre objectif est d’expliquer le choix des firmes multinationales entre les alliances avec prise de participation et les alliances sans prise de participation pour investir en R&D à l’étranger. Les déterminants du choix peuvent être contractuels ou cognitifs. Nos résultats montrent que les alliances sans prise de participation sont choisies en cas d’une spécificité des actifs et de fréquence moyennes ou faibles des transactions et au cas où les firmes parentes détiennent des capacités en R&D similaires. Nos résultats montrent aussi que les firmes multinationales n’optent pas nécessairement pour les alliances à fort degré d’interdépendance organisationnelle dans un objectif d’exploration de…
Le choix de la forme organisationnelle en matière d’investissement en R&D à l’étranger par les firmes multinationales:la contribution de la théorie d…
2008
(VF)L’objectif de ce papier est d’évaluer la contribution de la théorie des coûts de transaction à l’explication du choix du mode de gouvernance des activités de R&D à l’étranger par les firmes multinationales. Nous avons identifié principalement trois grandes formes organisationnelles en matière d’investissement en R&D à l’étranger:l’internalisation totale, les alliances en R&D et l’externalisation totale (licences unilatérales). Suite à une étude quantitative par le biais d’un questionnaire diffusé auprès de 769 firmes multinationales, nos principaux résultats montrent que le choix de l’internalisation des activités de R&D est favorisé en cas de fréquence élevée des transactions, le choix…
The influence of culture on the economic freedom and the international business
2006
The firms who decide to expand their business in an international environment must modify their management style through international management. Certainly, international management must adapt their on functions to the different framework of the business development. The culture is a cardinally factor, being an essential component in the success equation of multinational companies. The culture, the habits and the attitudes became points of major interests on the global market. Their importance is obvious through numerous "blunders" which find out in international trade and international. For the success of international business the economies must bees free, but the economic freedom is inf…
August Karl Heylman's thoughts on the legal science
2020
August Heylman is one of the forgotten lawyers of the Kingdom of Poland in the 19th century. He was a practician, holding high positions in the then administration and judiciary of the Kingdom. At the same time he occupied himself with scholarly activity. He was one of the main advocates of the historical school of law in the Polish legal science in the 19th century as well as a co-creator of one of the best-known Polish scientific journals edited under the title Themis Polska.
eIF2α confers cellular tolerance to S. aureus α-toxin
2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to the small pore forming S. aureus α-toxin. Sensitization depended on expression of mADAM10, the murine ortholog of a proposed high-affinity receptor for α-toxin in human cells. Similarly, eIF2α (S51A/S51A) MEFs, which harbor an Ala knock-in mutation at the regulated Ser51 phosphorylation site of eukaryotic translation initiation factor 2α, were hyper-sensitive to α-toxin. Inhibition of translation w…