Search results for "FACTOR"
showing 10 items of 17757 documents
Role of the NF-kB pathway and nitric oxide in mammary gland involution after weaning. Implications in breast cancer
2013
INTRODUCCIÓN La glándula mamaria es un órgano dinámico que alcanza su máximo desarrollo funcional con la lactancia, momento en el cual, a través de la producción de leche, aporta nutrientes y protección inmunológica a las crías de los mamíferos. Cuando la lactancia finaliza con el destete, el exceso de tejido glandular debe desaparecer y la glándula sufre una extensa remodelación hasta alcanzar nuevamente un estado pre-gestacional, preparada para un nuevo ciclo. La involución del tejido mamario es un proceso complejo durante el cual se suceden de forma coordinada una serie de eventos como la muerte de las células epiteliales secretoras, la proliferación de tejido adiposo circundante y la re…
The interactive effects of various nitrogen fertiliser formulations applied to urine patches on nitrous oxide emissions in grassland
2017
AbstractPasture-based livestock agriculture is a major source of greenhouse gas (GHG) nitrous oxide (N2O). Although a body of research is available on the effect of urine patch N or fertiliser N on N2O emissions, limited data is available on the effect of fertiliser N applied to patches of urinary N, which can cover up to a fifth of the yearly grazed area. This study investigated whether the sum of N2O emissions from urine and a range of N fertilisers, calcium ammonium nitrate (CAN) or urea ± urease inhibitor ± nitrification inhibitor, applied alone (disaggregated and re-aggregated) approximated the N2O emission of urine and fertiliser N applied together (aggregated). Application of fertili…
Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis
2018
Objectives Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs wer…
Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway.
2022
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is a crucial step in tumor growth and dissemination. Given the ability of tumors to interfere with multiple or different molecular pathways to promote angiogenesis, there is an increasing need to therapeutically block tumor progression by targeting multiple antiangiogenic pathways. Natural polyphenols present health-protective properties, which are likely attributed to their ability to activate multiple pathways involved in inflammation, carcinogenesis, and angiogenesis. Recently, increased attention has been addressed to the ability of flavonoids, the most abundant polyphenols in the diet, t…
Radioterapia adapatada al riesgo determinado por test de expresión genética múltiple en estadios iniciales de cáncer de mama y su impacto en el trata…
2020
INTRODUCCIÓN: El cáncer de mama (CM) estadio inicial representa aproximadamente la mitad de las enfermas con receptores hormonales (RH) positivos y sin invasión o con mínima afectación ganglionar locorregional al diagnóstico. El tratamiento adyuvante en estas pacientes se basa en la administración secuencial de radioterapia (RT) adyuvante, quimioterapia (QT) y hormonoterapia o terapia hormonal exclusiva (HT). Numerosos estudios prospectivos han demostrado que la incorporación de los test genómicos a la práctica clínica habitual tiene un impacto significativo en la decisión del tratamiento adyuvante del CM, sin embargo no existe la misma evidencia para los tratamientos locorregionales con ra…
Information Extraction from Binary Skill Assessment Data with Machine Learning
2021
Strength training exercises are essential for rehabilitation, improving our health as well as in sports. For optimal and safe training, educators and trainers in the industry should comprehend exercise form or technique. Currently, there is a lack of tools measuring in-depth skills of strength training experts. In this study, we investigate how data mining methods can be used to identify novel and useful skill patterns from a binary multiple choice questionnaire test designed to measure the knowledge level of strength training experts. A skill test assessing exercise technique expertise and comprehension was answered by 507 fitness professionals with varying backgrounds. A triangulated appr…
Mellommenneskelige aspekter i operasjonsteamet -operasjonssykepleieres opplevelser : kvalitative intervju med operasjonssykepleiere om opp- levelser …
2014
Masteroppgave i spesialsykepleie – Universitetet i Agder 2014 Background: Experiences from practice in surgical units led us to question what makes teamwork effective and elegant, and also reflect upon the causes of situations where the teamwork is less than optimal and team members become frustrated. Purpose and research question: We based our research design on some of the relational factors defined in Reeves et al. (2010) conceptual framework for interprofessional teamwork. This was done to explore how surgical nurses experience these factors in relation to cooperation in surgical teams. We chose the following research question: How do surgical nurses experience the relational factors of…
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
Etiological factors of chronic hepatitis in Italy: a 2014 national survey.
2017
Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However…
Bezpośredniość niewerbalna w kreowaniu postawy nauczyciela jako niespecyficznego czynnika w oddziaływaniach pedagogicznych
2013
One of the most important nonspecific pedagogical factors is the attitude of a teacher which presents especially credibility, self-confidence, commanding sympathy and empathy as well as interpersonal and physical attractiveness. The use of nonverbal signals presenting nonverbal straightforwardness is helpful to demonstrate these attitudes. It is expressed by frequent smiling to students, maintaining the eye contact, using friendly gestures and variety of vocal signals (differentiation of voice, avoiding the monotony), leaning forward to the students, relaxed posture, using the touch, the personal space and physical factors of a classroom (e.g. equipment, seating arrangements). Teachers who …