Search results for "FACTOR"

Risk Factors for COVID-19: Diabetes, Hypertension, and Obesity

2021

Introduction: The recent global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than 7 million people worldwide and been associated with more than 400,000 deaths. No clear information is known about all the potential risk factors for COVID-19 or what factors adversely influence its clinical course and mortality. Therefore, we analyzed the role of obesity, type 2 diabetes, and hypertension as risk factors for COVID-19. Methods: We identified articles for inclusion by searching PubMed and Google Scholar (last accessed 15 June 2020). Retrospective review of literature. Analysis of epidemiological data co…

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

2013

Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in t…

Metabolic syndrome

2015

OSA is a common disorder with major cardiovascular and metabolic consequences. OSA is often associated with metabolic syndrome, a cluster of cardiometabolic risk factors, and prevalence of metabolic syndrome is particularly high in OSA patients. The role of obesity as a risk factor for OSA has been shown in population and clinical studies, and increased adipose tissue volume and neck circumference are closely linked with OSA, even though major sex-related differences exist. Besides OSA treatment, cardiometabolic risk factors should be assessed and possibly corrected in all OSA patients in order to reduce adverse events. Occurrence of metabolic syndrome should be investigated, and modifiable…

Obesity and diabetes-Not only a simple link between two epidemics

2018

Summary Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM—type 2 diabetes—but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut …

Organisational climate and employee health outcomes: a systematic review

2019

Organisational climate, particularly safety climate, has been documented as a crucial element in promoting occupational health and safety. However, most previous studies have focused more on safety issues (e.g., injuries and accidents) rather than health outcomes (e.g., illnesses, stress, etc). A comprehensive review is also lacking in relation to understanding the organisational climate–health relationship between different levels of analysis, different data sources and different analytical procedures. We conducted a systematic review to investigate previous scholarly contributions to organisational climate and health. The reviewed articles were obtained from three databases: ISI Web of Kn…

Odorants' metabolism in Human: a critical role in odor perception revealed

2018

Système olfactif et neurobiologie

2006

Les connaissances neurobiologiques sur l’odorat progressent désormais rapidement depuis la découverte des récepteurs des odorants, remarquables par leur grand nombre et leur diversité. Des réponses sont maintenant apportées aux questions posées par les propriétés originales de la perception olfactive dont beaucoup sont déterminées dès le niveau de l’organe olfactif, et sont fortement déterminées par la génétique. Les connaissances génétiques sur les récepteurs dévoilent une considérable réduction du nombre de gènes olfactifs fonctionnels dans l’espèce humaine et alimentent une réflexion sur l’évolution de l’odorat. Autre avancée riche de promesses : l’application à l’olfaction des méthodes …

Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax

2019

Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro‐survival and anti‐apoptotic roles through molecule phosphorylated extracellular signal‐regulated kinase1/2 (p‐ERK1/2) in cardiomyocytes. However, it is still unclear if silencing of C3G may increase cell survival inhibition and apoptosis in cardiomyocytes, and whether C3G silence induced injuries are reduced by the overexpression of C3G through regulation of p‐ERK1/2 and pro‐apoptotic molecule Bax. In this study, the rat‐derived H9C2 cardiomyocytes were infected with C3G small hairpin RNA interference recombinant lentiviruses, which silenced the endogenous C3G expression in the ca…

WRKY gene family drives dormancy release in onion bulbs

2022

Onion (Allium cepa L.) is an important bulb crop grown worldwide. Dormancy in bulbous plants is an important physiological state mainly regulated by a complex gene network that determines a stop of vegetative growth during unfavorable seasons. Limited knowledge on the molecular mechanisms that regulate dormancy in onion were available until now. Here, a comparison between uninfected and onion yellow dwarf virus (OYDV)-infected onion bulbs highlighted an altered dormancy in the virus-infected plants, causing several symptoms, such as leaf striping, growth reduction, early bulb sprouting and rooting, as well as a lower abscisic acid (ABA) level at the start of dormancy. Furthermore, by compar…

Vapaalaskuvälineiden ja -brändien eWOM-viestinnän motivaatiotekijät

2015

Viestintä erilaisissa online-kanavissa on nykypäivänä yleinen tapa olla vuoro-vaikutuksessa tuttujen, mutta myös tuntemattomien henkilöiden kanssa. Verkkovälitteinen suusanallinen viestintä, eWOM-viestintä on noussut digitaalisessa maailmassa tärkeäksi markkinointivälineeksi yrityksille. eWOM-viestintä ja online-suosittelu on osa jokapäiväistä vuorovaikutusta arvostelusivustoilla, so-siaalisissa verkkoyhteisöissä, blogeissa, sisällönjakosivustoilla sekä muissa sosi-aalisen median kanavissa. eWOM-viestintä on tärkeää kaikille organisaatioille, se viestittää yritykselle kuluttajien asenteista ja mielipiteistä tuotteita tai palve-luja kohtaan. Kuluttajien asenteet ja mielipiteet ovat tärkeitä …