Search results for "FAD"

The Wigner Distribution of Sum-of-Cissoids and Sum-of-Chirps Processes for the Modelling of Stationary and Non-Stationary Mobile Channels

2016

This paper concerns the time-frequency analysis of stationary and non-stationary multipath flat fading channels. For the modelling of stationary multipath fading channels, we use a sum-of-cisoids (SOCi) process, while the non-stationary channel is modelled by a sum-of-chirps (SOCh) process that captures the time-variant Doppler effect caused by speed variations of the mobile station. For the time-frequency analysis, we apply the concept of the Wigner distribution. Closed-form solutions are provided for the Wigner distribution of SOCi and SOCh processes. It is shown that the obtained Wigner distributions can be expressed by the sum of an auto-term representing the true Doppler power spectral…

A Non-Stationary Mobile-to-Mobile Channel Model Allowing for Velocity and Trajectory Variations of the Mobile Stations

2017

In mobile-to-mobile (M2M) communication systems, both the transmitter and the receiver are moving with a certain velocity, which is usually assumed to be constant over time. However, in realistic propagation scenarios, the velocity of the mobile stations (MSs) is subject to changes resulting in a non-stationary fading process. In this paper, we develop a non-stationary narrow-band M2M multipath fading channel model, where the transmitter and the receiver experience changes in their velocities and trajectories. For this model, we derive expressions for the local autocorrelation function (ACF), the Wigner-Ville spectrum, the local average Doppler shift, and the local Doppler spread under isot…

Rateless Codes Performance Tests On Terrestrial FSO Time-Correlated Channel Model

2012

Free Space Optics (FSO) links are affected by several impairments: optical turbulence, scattering, absorption, and pointing. In particular, atmospheric optical turbulence generates optical power fluctuations at the receiver that can degrade communications with fading events, especially, in high data rate links. A way to mitigate FSO link outages can be to add a coding to communications. Nevertheless, in order to study innovative solutions (software or hardware) and to improve the FSO link performance it needs accurate testing models. In this paper we describe an accurate time-correlated channel model able to predict random temporal fluctuations of optical signal irradiance caused by optical…

Lauroside B, a Megastigmane Glycoside from Laurus Nobilis (Bay Laurel) Leaves, Induces Apoptosis in Human Melanoma Cell Lines by Inhibiting NF-κB Act…

2010

Malignant melanoma is a highly aggressive tumor that frequently resists chemotherapy, so the search for new agents for its treatment is of great importance. In the present study, the antiproliferative propensity against human melanoma cell lines of lauroside B (1), a megastigmane glycoside isolated from Laurus nobilis (bay laurel) leaves, was investigated. This compound suppressed the proliferation of three human melanoma cell lines, namely, A375, WM115, and SK-Mel-28. The 1-induced inhibition of human melanoma cell proliferation was due to the induction of apoptosis, as demonstrated by FACS analysis with annexin V/PI staining and confirmed by activation of caspase-3 and by the cleavage of …

Diagonal space time hadamard codes with erasure decoding algorithm

2005

A major challenge in the area of space time (ST) codes is to find codes suitable for efficient decoding, thus overcoming the problem of many existing ST code designs which require maximum-likelihood (ML) decoding. A solution could be to apply single-input single-output (SISO) channel codes and theory over temporal channel fading to the multi-input single-output (MISO) code construction and classical suboptimum decoding methods. For these purposes, an ST code construction which allows the use of efficient decoding algorithms is described. We propose a concatenated code, where the inner code is the diagonal ST Hadamard (D-STH) code with Paley constructions and the outer code is an algebraic b…

Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors

2014

Apoptosis signaling is involved in both physiological tissue homeostasis and acute and chronic diseases. The role of regulatory apoptosis signaling molecules and their organ-specific functions are less defined. Therefore, we investigated the loss of the anti-apoptotic cellular FLICE-inhibitory protein (cFLIP) and the mechanisms of the resulting lethal organ failure in vivo using inducible knockout mice. These were generated by crossing floxed cFLIP mice to a tamoxifen inducible Rosa26-creERT2 mouse strain. Death following global loss of cFLIP resulted from liver failure, accumulation of M1-polarized macrophages and accompanying hepatic cell death and inflammation. Apoptosis was also promine…

Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways

2011

Hepatocellular carcinoma (HCC) remains a disease with a poor prognosis despite recent advances in the pathophysiology and treatment. Although the disease is biologically heterogeneous, dysregulation of cellular proliferation and apoptosis both occur frequently and contribute to the malignant phenotype. Chronic liver disease is associated with intrahepatic inflammation which promotes dysregulation of cellular signaling pathways; this triggers proliferation and thus lays the ground for expansion of premalignant cells. Cancer emerges when immunological control fails and transformed cells develop resistance against cell death signaling pathways. The same mechanisms underlie the poor responsiven…

Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis

2011

Two groups identify the regulation of death-receptor-induced necroptosis as an epithelial intrinsic mechanism that is important for the maintenance of immune homeostasis and the prevention of intestinal inflammation in mice. Welz et al. describe an unexpected physiological function for FADD (Fas-associated protein with death domain), an adaptor protein required for death-receptor-induced apoptosis. Mice with intestinal epithelial specific knockout of FADD develop severe colon inflammation due to increased death of FADD-deficient colonic epithelial cells. Gunther et al. report a novel and unexpected function of caspase-8 in maintaining immune homeostasis in the gut. Caspase-8 expression by g…

158 Study of the Role of FAS-associated Death Domain Protein FADD in Brain Pathology by Conditional Gene Inactivation

2007

Design and Simulation of Measurement-Based Correlation Models for Shadow Fading

2011

This paper deals with the design of measurement-based correlation models for shadow fading. Based on the correlation model, we design a simulation model using the sum-of-sinusoids (SOS) method to enable the simulation of spatial lognormal processes characterizing real-world shadow fading scenarios. The model parameters of the simulation model are computed by applying the Lp-norm method (LPNM). This method facilitates an excellent fitting of the simulation model’s autocorrelation function (ACF) to that of measured channels. Our study includes an evaluation of all important statistical quantities of the proposed measurement-based simulation model, such as the probability density function (PDF…