Search results for "FAD"
showing 10 items of 292 documents
MICELLAR CHROMATOGRAPHIC PROCEDURE WITH DIRECT INJECTION FOR THE DETERMINATION OF SULFONAMIDES IN MILK AND HONEY SAMPLES
2001
The capability of liquid chromatography with micellar mobile phases of sodium dodecyl sulfate (SDS), of allowing the direct injection of biological fluids into reversed-phase columns, was applied to the determination of sulfonamides in milk and honey samples. The chromatographic behavior of a group of 15 sulfonamides was studied at pH 3.0 where the drugs showed a greater separation space. Acetonitrile was added to the mobile phase to decrease the retention of the most hydrophobic drugs and increase the efficiencies, which yielded a higher resolution. The samples were diluted with 0.10 M SDS to facilitate the solubilization of the matrix compounds and release the protein-bound drugs. The pro…
Experimental Studies on the Influence of Surfactants on Intestinal Absorption of Drugs Cefadroxil as model drug and sodium taurocholate as natural mo…
2011
The influence of the natural bile acid surfactant sodium taurocholate (CAS 81-24-3) on colic and duodenal (i.e. the proximal third of the small intestine) absorption of cefadroxil (CAS 50370-12-2) was studied using the in situ rat gut technique, and compared with the effect of sodium lauryl sulfate (CAS 151-21-3), the most widely used synthetic anionic surfactant. Previously, the stability, compatibility, and micelle-solubilization characteristics of taurocholate were assessed in order to correct, when necessary, the absorption results. White the passive absorption rate constants (kf, h-1) determined in colon in the presence of increasing lauryl sulfate concentrations showed an asymptotic v…
Triclosan induces Fas receptor-dependent apoptosis in mouse neocortical neurons in vitro
2014
Triclosan (TCS) is a commonly used antimicrobial agent in personal care and sanitizing products, as well as in household items. Numerous studies have demonstrated the presence of TCS in various human tissues. Several studies have reported the accumulation of TCS in fish and human brain tissue. The aim of the present study was to investigate the effect of TCS on apoptosis in mouse neocortical neurons after 7 days of culture in vitro following 3, 6 and 24 h of exposure. To explore the mechanism underlying the effects of TCS in neurons, we studied the activation and protein expression of the Fas receptor (FasR) and caspase- 8, caspase-9 and caspase-3, as well as DNA fragmentation in TCS-treate…
Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo
2005
Deregulation of apoptosis signalling is commonly found in cancer and results in resistance to cytotoxic therapies. Immunotherapy is a promising strategy to eliminate resistant cancer cells. The transfer of T-lymphocytes during allogeneic stem cell transplantation is clinically explored to induce a 'graft-versus-tumor' effect (GvT). Cytotoxic T-lymphocytes (CTL), which are major effectors of GvT, eliminate cancer cells by inducing apoptosis via multiple parallel pathways. Here, we study in vitro and in vivo the susceptibility of murine cancer cells engineered to express single antiapoptotic genes to CTL-mediated cytotoxicity. Interestingly, we find that single inhibitors of caspase activatio…
Non-regular network performance comparison between HSDPA and LTE
2010
In this paper we study and benchmark the performance of 3rd Generation Partnership Project (3GPP) High Speed Downlink Packet Access (HSDPA) and 3GPP Long Term Evolution (LTE) Downlink with constant bit rate type traffic. In addition a non-regular simulation scenario is considered using realistic propagation data and base station positions related to Tokyo city downtown area. HSDPA was introduced in 3GPP Release 5 and in further releases the technology has been improved with e.g. receive and transmit diversity technologies and support for higher order modulation schemes. LTE was introduced in 3GPP Release 8 with completely new physical layer and improved Radio Resource Management (RRM) funct…
La praxis de la retórica en la obra de Fadrique Furio Ceriol
2016
En este trabajo se actualiza la biografía de Fadrique Furio Ceriol, se presentan las ideas retórica de sus Institutionum Rheoricarum libri III y se analizan de acuerdo a esta retórica fragmentos de su obra en castellano El Concejo y consejeros del Príncipe, publicada en Lovaina en 1559.
La edición burgalesa de la Comedia de Calisto y Melibea: ¿manipulación lucrativa de su fecha de impresión?
2017
Se analiza el ejemplar de la Hispanic Society de la Comedia de Calisto y Melibea y la manipulación sometida durante el siglo XIX para hacerlo parecer como la editio princeps.
Reflexions on the Picture Book of the Printer Fadrique Biel of Basel
2016
Se estudia en este artículo la producción impresa ilustrada de la época incunable del impresor burgalés Fadrique Biel, Alemán de Basilea. La casi totalidad de sus libros con láminas en su interior han sido copiados de ejemplares procedentes de las prensas zaragozanas de los Hurus, y unos pocos imitan impresos franceses de finales del siglo X V . Posiblemente mantuvo una competencia desleal con los talleres que le sirvieron de inspiración. La innovación de los entalladores y cinceladores de la imprenta burgalesa es escasa, por lo que se pone en duda la originalidad de las láminas de la Comedia de Calisto y Melibea.
Utilidad del ganglio centinela en el cáncer de mama para disminuir la agresividad quirúrgica
2019
La afectación ganglionar se ha considerado hasta el momento un factor relevante para la supervivencia, estadiaje y tipo de tratamiento de las pacientes diagnosticadas de cáncer de mama. Se define al ganglio centinela (GC) como el primer ganglio de una cadena linfática que recibe el flujo linfático desde el tumor primario. Si este ganglio no contiene células tumorales es poco probable que el resto de ganglios axilares presenten enfermedad metastásica (1). La identificación del ganglio centinela puede sustituir a la linfadenectomía axilar para el estudio de extensión regional en el cáncer de mama, evitando su morbilidad asociada (2). Hoy en día, está aceptada la realización de la biopsia sel…
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8
2012
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIR domain-containing adapter inducing IFN-α (TRIF), have been demonstrated to contribute to dsRNA-induced cell death through caspase-8 and receptor interacting protein (RIP)1 in various human cancer cells. We provide here a detailed analysis of the caspase-8 activating machinery triggered in response to Poly(I:C) dsRNA. Engagement of TLR3 by dsRNA in both type I and type II lung cancer cells induces the formation of an atypical caspase-8-containing complex that is devoid of classical death receptors…