Search results for "FAILURE"
showing 10 items of 1977 documents
A cross‐cultural comparison of the roles of emotional intelligence, metacognition, and negative coping for health‐related quality of life in German v…
2018
Objectives Low emotional intelligence (EI) may predispose individuals to applying maladaptive coping strategies. This may maintain anxious worrying, which is highly prevalent in patients with chronic heart failure (CHF) and may affect mental (MCS) and physical component summaries (PCS) of health-related quality of life (HRQoL). Design The current study is a cross-sectional and cross-cultural survey. Methods N = 200 outpatients with CHF were recruited at cardiology institutes in Germany and Pakistan and assessed with self-report questionnaires. Results Path analysis (χ2 (4) = 7.59, p = .11, GFI = .99) revealed that the expected associations between low EI and lower SF-36 MCS and PCS of HRQoL…
Food traditions and consumer preferences for cured meats: Role of information in geographical indications
2021
Abstract Growth and development are two economic concepts that should go hand in hand. In a specific territory, the search for sustainable development is intertwined with the objectives of private operators but also with the public ones of collective well-being. As we know from the economic literature, the presence of information asymmetries leads to market failure as sustainability in the production of food products determines positive externalities that are not adequately remunerated. In this work some evolutionary trends in the demand for cured meats are analyzed, highlighting the relevant innovations introduced by sustainable consumption. Faced with this evolution of demand, with consum…
Economic reasoning and creative industries progress
2017
ABSTRACTThis article offers a theoretical discussion on how major neoclassical economic theory assumptions blur the understanding of creative industries. By distinguishing between creative-rational and creative-intuitive industries, with different compositions of commercial and cultural attributes, we particularly show how the latter sector has characteristics and dynamics that are incompatible with a theory based on preference rationality, profit maximisation and equal access to information among actors. When customer utility is composed of economic, as well as aesthetic, spiritual, social, historical, symbolic and authenticity values, then all these will affect customers' willingness to p…
Role of curcumin in idiopathic pulmonary arterial hypertension treatment: A new therapeutic possibility
2013
The idiopathic pulmonary arterial hypertension is a complex disease that mainly affects pulmonary arterial circulation. This undergoes a remodeling with subsequent reduction of flow in the small pulmonary arteries. Because of this damage an increased vascular resistance gradually develops, and over time it carries out in heart failure. The inflammatory process is a key element in this condition, mediated by various cytokines. The inflammatory signal induces activation of NF-κB, and prompts TGF-β-related signaling pathway. Clinical evolution leads to progressive debilitation, greatly affecting the patient quality of life. The actual therapeutic approaches, are few and expensive, and include …
Effect of saliva contamination on bracket failure with a self-etching primer: A prospective controlled clinical trial
2010
Introduction The aim of this study was to evaluate in vivo the effect of saliva contamination at different stages of the bonding procedure on the bond failure rate and the adhesive remaining on teeth after debonding brackets bonded with a hydrophilic self-etching primer (Transbond Plus self-etching primer [TSEP], 3M Unitek, Monrovia, Calif). Methods This was a prospective controlled clinical trial. The sample consisted of 46 patients with similar treatment plans and mechanotherapies. Stainless steel brackets (n = 531) were bonded with TSEP. The patients were divided into 2 groups: contamination with saliva before TSEP application and contamination with saliva after TSEP application. In both…
Effect of cyclic loading on fracture strength and microleakage of a quartz fiber dowel with different adhesive, cement and resin core material combin…
2010
Background: This study evaluated the performance of different adhesive-cement-core combinations coupled with quartz fiber dowels after cyclic loading and fracture strength tests and assessed the microleakage using dye penetration method. Methods: Forty maxillary canines (n=10 per group) were restored with fiber dowels (Quartz fiber DT Light Post) and four adhesive-cement-core material combinations [(Group 1: All-Bond 2+C&B (root) / All-Bond 2+Biscore (core); Group 2: All-Bond 2+Bisfil 2B (root) / All-Bond 2+Bisfil 2B (core); Group 3: Scotchbond 1+RelyX ARC (root) / Scotchbond 1+Supreme (core); Group 4: RelyX Unicem (root) / Scotchbond 1+Filtek Supreme (core)]. The specimens were initially c…
Influence of the type of reciprocating motion on the cyclic fatigue resistance of reciprocating files in a dynamic model
2021
Abstract Background The aim of this study was to compare the influence of two novel reciprocating movements on the cyclic fatigue resistance of endodontic reciprocating files. Methods 30 Procodile® (Komet Medical, Lemgo, Germany) files were selected in this study and distributed according to the following study groups depending on the movements to be performed: ReFlex Dynamic (n = 10), ReFlex Smart (n = 10) and Reciproc (n = 10) reciprocating movement. These files were fixed to a specific dynamic cyclic fatigue device designed and manufactured by 3D impression to simulate the pecking motion performed by the operator. The time to failure and the number of cycles of in-and-out of the endodont…
Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.
2010
Parvovirus B19 is a widespread virus with diverse clinical presentations. The viral nonstructural protein, NS1, binds to and cleaves the viral genome, and induces apoptosis when transfected into nonpermissive cells, such as hepatocytes. We hypothesized that the cytotoxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, we found that NS1 covalently binds to cellular DNA and is modified by PARP, an enzyme involved in repairing single-stranded DNA nicks. We furthermore discovered that the DNA nick repair pathway initiated by poly(ADPribose)polymerase and the DNA repair pathways initiated by …
Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs
2015
International audience; Fanconi anemia is a DNA repair-deficiency syndrome mainly characterized by cancer predisposition and bone marrow failure. Trying to restore the hematopoietic function in these patients, lentiviral vector-mediated gene therapy trials have recently been proposed. However, because no insertional oncogenesis studies have been conducted so far in DNA repair-deficiency syndromes such as Fanconi anemia, we have carried out a genome-wide screening of lentiviral insertion sites after the gene correction of Fanca-/- hematopoietic stem cells (HSCs), using LAM-PCR and 454-pyrosequencing. Our studies first demonstrated that transduction of Fanca-/- HSCs with a lentiviral vector d…
Vulnerability of a Damaged Bridge Abutment in a Seismic Area
2018
The case of the abutment of a motorway urban viaduct damaged by human intervention is presented. Built in the 1960s, it lies in a critical seismic area and the human-induced damage involved the elements of the abutment foundation. The structure is geometrically complex and the evaluations of its structural safety were carried out by applying Italian codes from different times: those concerning the time of construction, those of a recent past (1996), and those of the present (2008), inspired by Eurocodes. A comparison between the safety checks performed and the requirements of all these codes is presented and discussed, especially regarding safety coefficients after the damage was done. Two …