Search results for "FARMACEUTICO"

CATIONIC SLN AS TARGETING GENE DELIVERY SYSTEMS FOR HEPATOCELLULAR CARCINOMA

2014

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related deaths. In the United States, the incidence of HCC has almost tripled during the past two decades and HCC has become one of the fastest growing cancers. While surgical removal of tumor tissues is an effective approach to protect relatively healthy liver tissue, it is only applicable to a small subset of HCC patients with specific pathological conditions, such as confined tumor mass without portal hypertension. Therefore, there is an urgent need to develop novel therapeutic strategies to treat this deadly disease. Systemic tumor-targeted gene delivery is attracting increasin…

PREPARATION AND CHARACTERIZATION OF CURCUMIN-LOADED LIPID NANOPARTICLES WITH IMPROVED ANTI-CANCER THERAPEUTIC EFFICACY

2011

Development of nimesulide loaded solid lipid nanoparticles.

2009

DNA PLASMID DELIVERY INTO HEPATOCELLULAR CARCINOMA CELLS BY COMPLEXATION WITH SOLID LIPID NANOPARTICLES

2014

Effects of kind and amount of surfactants on physical-chemical properties of cationic solid lipid nanoparticles (SLN) for the treatment of hepatocell…

2014

Encapsulation of sorafenib into lipid nanoparticles improves its antitumor activity.

2013

New amphiphilic derivatives of poly(ethylene glycol) as surface modifiers of colloidal drug carriers

2009

SELF ASSEMBLED AND CROSSLINKED FIBRILLAR SCAFFOLDS FOR CARTILAGE REGENERATION.

2010

Is Acetaldehyde a substance of abuse? Evidence from a free-access, three-bottle choice paradigm

2012

At present, neuroscience literature dealing with Acetaldehyde (ACD), ethanol first metabolite, as a drug of abuse, reported conditioned taste aversion paradigm and conditioned place preference, following ICV or i.p. administration. No reports exist on ACD oral self-administration probably because of its high volatility. For this reason, this pilot study was aimed at the evaluation of ACD concentration in aqueous solutions, and consequently to the rat drinking behaviour when acetaldehyde was presented in a free-access paradigm together with water and a sweet solution. Preliminarly we investigated the loss of ACD content in aqueous standard solutions. For the investigation of ACD concentratio…

DA-Phen as a new potential DA-mimetic agent for treatment of alcohol addiction: preclinical in vivo studies

2015

Rewarding and reinforcing properties of alcohol are mediated by activation of the mesolimbic dopaminergic system1. This neurosystem is hypofunctional in the addicted brain, even beyond somatic and psychological signs of withdrawal. Boosting strategy on the dopaminergic tone could represent a valid approach to alcohol addiction treatment2. The effects of a new dopamine conjugate3 (2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide, DA-Phen) on operant behaviour and on withdrawal behaviour, following alcohol deprivation, were evaluated. The concentration of acetaldehyde (ACD), ethanol's first metabolite, as an indirect measure of the possible DA-Phen modulation in alcohol consum…