Search results for "FARMACEUTICO"
showing 10 items of 419 documents
Galactosylated Polymer/Gold Nanorods Nanocomposites for Sustained and Pulsed Chemo-Photothermal Treatments of Hepatocarcinoma
2022
In this paper, we propose a rational design of a hybrid nanosystem capable of locally delivering a high amount of hydrophobic anticancer drugs (sorafenib or lenvatinib) and heat (hyperthermia) in a remote-controlled manner. We combined in a unique nanosystem the excellent NIR photothermal conversion of gold nanorods (AuNRs) with the ability of a specially designed galactosylated amphiphilic graft copolymer (PHEA-g-BIB-pButMA-g-PEG-GAL) able to recognize hepatic cells overexpressing the asialoglycoprotein receptor (ASGPR) on their membranes, thus giving rise to a smart composite nanosystem for the NIR-triggered chemo-phototherapy of hepatocarcinoma. In order to allow the internalization of A…
ANTICANCER RELEASING FILMS AND POROUS SCAFFOLDS BASED ON PHYSICALLY ASSEMBLED HYALURONIC ACID DERIVATIVES
2012
Sistemi sopramolecolari cationici innovativi per la veicolazione polmonare dei bioattivi.
2010
LIPID NANOPARTICLES AS CARRIERS FOR TARGETED RELEASE OF RILUZOLE INTO THE CENTRAL NERVOUS SYSTEM
2009
LIPID NANOPARTICLE SYSTEMS CONTAINING CURCUMIN: PREPARATION AND CHARACTERIZATION
2008
FERULIC ACID LOADED SOLID LIPID NANOPARTICLES PROTECTS LAN5 NEUROBLASTOMA CELL LINE BY Ab-AMYLOID OXIDATIVE STRESS
2008
Una soluzione oleosa capace di prevenire la formazione di biofilm di Listeria monocytogenes
2014
La Listeria monocytogenes è un batterio patogeno che può causare gastroenteriti lievi o gravi infezioni del sangue e del sistema nervoso, con tassi di mortalità tra il 20% e il 67%. È trasmesso all'uomo prevalentemente attraverso il cibo e può colpire le donne in gravidanza causando l’aborto. La malattia causata da questo batterio ha il nome di listeriosi e appartiene al gruppo di patologie definibili come “tossinfezioni alimentari”. Diversi focolai di listeriosi, associati con i prodotti alimentari “pronti da mangiare”, sono stati attribuiti a una combinazione di contaminazione di L. monocytogenes, durante la lavorazione e la successiva crescita nei prodotti durante lo stoccaggio. Oltre a …
Lipid nanocarrier for the treatment of hepatocellular carcinoma
2013
Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Unlike most solid tumors the incidence and mortality of HCC have increased in the United States and Europe in the past decade. Most patients are diagnosed at advanced stages, so there is an urgent need for new systemic therapies [1,2]. To improve the delivery of therapeutic agents to tumor cells in vivo it’s necessary to overcome several problems, such as drug resistance at the tumor level due to physiological barriers (non cellular based mechanism), drug resistance at the cellular level (cellular mechanism), drug distribution, biotransformation and clearance of antic…